Determining posterior vitreous structure by analysis of images obtained by AI-based 3D segmentation and ultrawidefield optical coherence tomography

AimsTo determine the three-dimensional (3D) structure of the vitreous fluid including the posterior precortical vitreous pockets (PPVP), Cloquet’s canal and cisterns in healthy subjects by AI-based segmentation of the vitreous of swept-source optical coherence tomography (OCT) images. In addition, to analyse the vitreous structures over a wide and deep area using ultrawidefield swept-source OCT (UWF-OCT).MethodsTen eyes of six patients with the mean age was 40.7±8.4 years and the mean refractive error (spherical equivalent) was −3.275±2.2 diopters were examined.ResultsIn the UWF OCT images, the structure of the vitreous was observed in detail over 23 mm wide and 5 mm area. AI-guided analyses showed the complex 3D vitreous structures from any angle. Cisterns were observed to overlie the PPVP from the anterior. The morphology and locations of the cisterns varied among the subjects but tended to be similar in the two eyes of one individual. Cisterns joined the PPVPs superior to the macula to form a large trunk. This joined trunk was clearly seen in 3D images even in eyes whose trunk was not detected in the B scan OCT images. In some eyes, the vitreous had a complex appearance resembling an ant nest without large fluid-filled spaces.ConclusionsA combination of UWF-OCT and 3D imaging is very helpful in visualising the complex structure of the vitreous. These technologies are powerful tools that can be used to clarify the normal evolution of the vitreous, pathological changes of vitreous and implications of vitreous changes in various vitreoretinal diseases.

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Three-dimensional segmentation and depth-encoded visualization of choroidal vasculature using swept-source optical coherence tomography

Experimental Biology and Medicine ◽

10.1177/15353702211028540 ◽

2021 ◽

pp. 153537022110285

Author(s):

Hao Zhou ◽

Tommaso Bacci ◽

K Bailey Freund ◽

Ruikang K Wang

Keyword(s):

Optical Coherence Tomography ◽

Three Dimensional ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Full Thickness ◽

Swept Source ◽

Automated Method ◽

Choroidal Imaging ◽

Choroidal Vasculature ◽

Choroidal Vessels

The choroid provides nutritional support for the retinal pigment epithelium and photoreceptors. Choroidal dysfunction plays a major role in several of the most important causes of vision loss including age-related macular degeneration, myopic degeneration, and pachychoroid diseases such as central serous chorioretinopathy and polypoidal choroidal vasculopathy. We describe an imaging technique using depth-resolved swept-source optical coherence tomography (SS-OCT) that provides full-thickness three-dimensional (3D) visualization of choroidal anatomy including topographical features of individual vessels. Enrolled subjects with different clinical manifestations within the pachychoroid disease spectrum underwent 15 mm × 9 mm volume scans centered on the fovea. A fully automated method segmented the choroidal vessels using their hyporeflective lumens. Binarized choroidal vessels were rendered in a 3D viewer as a vascular network within a choroidal slab. The network of choroidal vessels was color depth-encoded with a reference to the Bruch’s membrane segmentation. Topographical features of the choroidal vasculature were characterized and compared with choroidal imaging obtained with indocyanine green angiography (ICGA) from the same subject. The en face SS-OCT projections of the larger choroid vessels closely resembled to that obtained with ICGA, with the automated SS-OCT approach proving additional depth-encoded 3D information. In 16 eyes with pachychoroid disease, the SS-OCT approach added clinically relevant structural details, including choroidal thickness and vessel depth, which the ICGA studies could not provide. Our technique appears to advance the in vivo visualization of the full-thickness choroid, successfully reveals the topographical features of choroidal vasculature, and shows potential for further quantitative analysis when compared with other choroidal imaging techniques. This improved visualization of choroidal vasculature and its 3D structure should provide an insight into choroid-related disease mechanisms as well as their responses to treatment.

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Clinical examinations of anterior eye segments by three-dimensional swept-source optical coherence tomography

10.1117/12.698968 ◽

2007 ◽

Cited By ~ 2

Author(s):

Yoshiaki Yasuno ◽

Masahiro Yamanari ◽

Hideki Mori ◽

Keisuke Kawana ◽

Yuji Watanabe ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Three Dimensional ◽

Optical Coherence ◽

Swept Source

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Sequential imaging of a case of choroidal osteoma using swept-source OCT and optical coherence tomography angiography: A 4-year follow-up study

Indian Journal of Ophthalmology ◽

10.4103/ijo.ijo_919_19 ◽

2019 ◽

Vol 67 (12) ◽

pp. 2097

Author(s):

Sugaranjini Galiyugavaradhan ◽

ThirumaleshM Basavaraj

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Swept Source ◽

Follow Up Study ◽

Choroidal Osteoma ◽

Swept Source Oct

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Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

Clinical and Experimental Otorhinolaryngology ◽

10.21053/ceo.2019.00766 ◽

2020 ◽

Vol 13 (2) ◽

pp. 106-112 ◽

Cited By ~ 1

Author(s):

Se-Joon Oh ◽

Il-Woo Lee ◽

Soo-Geun Wang ◽

Soo-Keun Kong ◽

Hong-Ki Kim ◽

...

Keyword(s):

Animal Model ◽

Optical Coherence Tomography ◽

Inner Ear ◽

Oval Window ◽

Diagnostic Information ◽

Optical Coherence ◽

Swept Source ◽

Diagnostic Technology ◽

Swept Source Oct ◽

Rats And Mice

Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging.Methods. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images.Results. The middle ear microstructures such as ossicles, stapedial artery and oval window through the tympanic membrane with the OCT could be confirmed in both rats and mice. It was also possible to obtain the inner ear images such as each compartment of the cochlea in the mice, but the bone covering bulla needed to be removed to visualize the inner ear structures in the rats which had thicker bulla. The bony thickness covering the cochlea could be measured, which showed no significant differences between OCT and histologic image at all turns of cochlea.Conclusion. OCT has been shown a promising technology to assess real-time middle and inner ear microstructures noninvasively with a high-resolution in the animal model. Therefore, OCT could be utilized to provide additional diagnostic information about the diseases of the middle and inner ear.

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Three-dimensional shape measurement of micro-lens arrays using full-field swept-source optical coherence tomography

Optics and Lasers in Engineering ◽

10.1016/j.optlaseng.2010.03.002 ◽

2010 ◽

Vol 48 (11) ◽

pp. 1145-1151 ◽

Cited By ~ 14

Author(s):

Tulsi Anna ◽

Chandra Shakher ◽

Dalip Singh Mehta

Keyword(s):

Optical Coherence Tomography ◽

Three Dimensional ◽

Shape Measurement ◽

Optical Coherence ◽

Swept Source ◽

Full Field ◽

Dimensional Shape ◽

Three Dimensional Shape ◽

Micro Lens

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Optical Coherence Tomography in Vitreoretinal Interface Disorders

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0099 ◽

2018 ◽

pp. 236-243

Keyword(s):

Optical Coherence Tomography ◽

Time Domain ◽

Treatment Modalities ◽

Optical Coherence ◽

Vitreoretinal Interface ◽

Swept Source ◽

Appearance Time ◽

Swept Source Oct ◽

New Treatment ◽

Pathologic Processes

Optical coherence tomography (OCT), which is in use for about 20 years, facilitated the evaluation of the vitreoretinal interface, improved our understanding of its pathologic processes, and paved the way to new treatment approaches. By order of appearance, time-domain, spectral-domain, and swept-source OCT technologies redefined vitreoretinal interface disorders and their treatment modalities.

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