THE DETERMINATION OF ARTERIAL BLOOD PRESSURE IN CLINICAL PRACTICE

BMJ ◽  
1905 ◽  
Vol 1 (2313) ◽  
pp. 967-968
Author(s):  
S. Wilks
Keyword(s):  
Blood Pressure ◽  
Clinical Practice ◽  
Arterial Blood Pressure ◽  
Arterial Blood

Effect of norepinephrine on plasma free fatty acids in dogs treated with reserpine

1963 ◽  
Vol 205 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Francois M. Abboud ◽  
Michael G. Wendling ◽  
John W. Eckstein
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Arterial Blood Pressure ◽  
Pressor Response ◽  
Maximal Increase ◽  
Arterial Blood ◽  
Anesthetized Dogs ◽  
Plasma Ffa

Some adrenergic blocking drugs reduce the mobilization of free fatty acids (FFA) in response to administration of catecholamines. The present experiments were done to see if potentiation of the pressor effect of norepinephrine by reserpine is accompanied by a greater increase in plasma FFA. Norepinephrine was infused intravenously into 16 anesthetized dogs. Eight of them had been treated with reserpine, 0.25 mg/kg daily, intraperitoneally for 2 days; the others were not treated. Arterial blood samples were drawn before, during, and after norepinephrine for determination of plasma FFA concentrations. Systemic arterial blood pressure was measured continuously. In the treated animals the maximal increase in arterial blood pressure as well as the progressive increments in FFA concentration were greater than in the untreated dogs. The experiments indicate that potentiation of the pressor response to norepinephrine after reserpine is accompanied by a greater FFA response.

Peripheral Resistance Changes and Blood Pooling After Endotoxin in Eviscerated Dogs

1958 ◽  
Vol 195 (3) ◽  
pp. 631-634 ◽  
Author(s):  
Lerner B. Hinshaw ◽  
Robert P. Gilbert ◽  
Hiroshi Kuida ◽  
Maurice B. Visscher
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Mean Arterial Blood Pressure ◽  
Total Peripheral Resistance ◽  
Peripheral Resistance ◽  
Endotoxin Shock ◽  
E Coli ◽  
Arterial Blood ◽  
Later Phase

Studies were performed on eviscerated dogs maintained with a constant cardiac inflow with and without injections of lethal amounts of E. coli endotoxin. Continuous recordings of mean arterial blood pressure and total venous return permitted determination of changes in total peripheral resistance and extent of vascular pooling. A significant fall in mean arterial blood pressure occurs within 30 minutes after endotoxin in the eviscerated dog with constant cardiac inflow. There is therefore a decrease in total peripheral resistance. There is also a small but significant increase in vascular pooling exceeding that seen without endotoxin but much reduced from that observed in noneviscerated animals given endotoxin. It is concluded that a decrease in vascular tone occurs after endotoxin and that it probably plays a significant role in the later phase of endotoxin shock in the dog.

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