A NOVEL SYSTEM TO ADDRESS ADHERENCE BARRIERS IN CLINICAL PRACTICE DECREASES ALLOGRAFT REJECTION FOR KIDNEY TRANSPLANT PATIENTS

2016 ◽  
Vol 25 (12) ◽  
pp. 1015.1-1015
Author(s):  
Charles Varnell ◽  
Kristin Rich ◽  
Melissa Nichols ◽  
Jodi Engelhardt ◽  
Devesh Dahale ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Increased circulating concentrations of interleukin 2 receptor during rejection episodes in heart- or kidney-transplant recipients

1990 ◽  
Vol 36 (12) ◽  
pp. 2106-2109 ◽  
Author(s):  
G C Zucchelli ◽  
A Clerico ◽  
R De Maria ◽  
M Carmellini ◽  
R Di Stefano ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Interleukin 2 ◽  
Clinical Markers ◽  
Kidney Transplant Recipients ◽  
Interleukin 2 Receptor ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
The Mean

Abstract Concentrations of interleukin 2 receptor (sIL-2R) have been suggested as a marker of rejection episodes after organ transplantation. To evaluate the analytical performance of a "sandwich-type" enzyme immunoassay method for sIL-2R and to verify whether increased concentrations of sIL-2R might be a useful marker of allograft rejection, we quantified sIL-2R in serum samples from heart- or kidney-transplant patients. The mean (+/- SD) pre-transplant value of sIL-2R (592 +/- 209 kilo-units/L) in heart-transplant patients was significantly higher (P less than 0.01) than that observed in controls (350 +/- 101 kilo-units/L). After heart transplantation, the concentrations of sIL-2R slowly decreased to baseline in successfully treated patients but increased significantly (1129 +/- 215 kilo-units/L; P less than 0.01) during acute rejection crisis. However, severe infections were also associated with a significant increase of sIL-2R, so the sIL-2R test is not specific for allograft rejection. The mean pre-transplant concentration of sIL-2R was also increased (1943 +/- 878 kilo-units/L) in 26 renal-transplant patients; after transplantation, this value returned to normal, as did that for creatinine, but persisted steadily high in five patients who experienced acute tubular necrosis. In this group of patients, the sIL-2R concentration increased by 1.5- to fourfold, both during acute rejection episodes and in clinically evident infection; thus measurement of creatinine and sIL-2R concentrations can help to distinguish between rejection, infection, and cyclosporine toxicity. In two episodes of mild cyclosporine-induced nephrotoxicity, we observed slight increases in serum creatinine (which returned to baseline when the cyclosporine dose was decreased) not associated with an increase in sIL-2R. We conclude that systematic monitoring of sIL-2R together with other biochemical and clinical markers may be useful in the management of kidney-transplant patients.

scholarly journals Differential impact of allograft rejection on kidney transplant patients with BK virus infection

2020 ◽  
Vol 34 (1) ◽  
pp. S93-S93
Author(s):  
Ji Won Min ◽  
Jae Berm Park ◽  
Jung Hwan Park ◽  
Jong-Won Park ◽  
Jaeseok Yang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Bk Virus ◽  
Differential Impact ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals DIFFERENTIAL IMPACT OF ALLOGRAFT REJECTION ON KIDNEY TRANSPLANT PATIENTS WITH BKV INFECTION

2020 ◽  
Vol 104 (S3) ◽  
pp. S370-S370
Author(s):  
Ji Won Min ◽  
Kang Woong Jun ◽  
Jae Berm Park ◽  
Jung Hwan Park ◽  
Jong-Won Park ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Allograft Rejection ◽  
Differential Impact ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Influence of polymorphisms in the vascular endothelial growth factor gene on allograft rejection after kidney transplantation: a meta-analysis

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 90
Author(s):  
Thanee Eiamsitrakoon ◽  
Phuntila Tharabenjasin ◽  
Noel Pabalan ◽  
Hamdi Jarjanazi ◽  
Adis Tasanarong
Keyword(s):  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Meta Analysis ◽  
Clinical Genetics ◽  
Nucleotide Polymorphisms ◽  
Transplant Patients ◽  
Increased Risk ◽  
Kidney Transplant Patients ◽  
Bonferroni Test

Background: Reported associations of allograft rejection in kidney transplant patients with VEGF single nucleotide polymorphisms (SNPs) have been inconsistent between studies, which prompted a meta-analysis to obtain more precise estimates. Methods: Using the PICO elements, kidney transplant patients (P) were compared by genotype data between rejectors (I) and non-rejectors (C) in order to determine the risk of allograft rejection (O) attributed to the VEGF SNPs. Literature search of four databases yielded seven articles. To calculate risks for allograft rejection, four SNPs were examined. Using the allele-genotype model we compared the variant (var) with the wild-type (wt) and heterozygous (var-wt) alleles. Meta-analysis treatments included outlier and subgroup analyses, the latter was based on ethnicity (Indians/Caucasians) and rejection type (acute/chronic). Multiple comparisons were corrected with the Bonferroni test. Results: Five highly significant outcomes (Pa < 0.01) survived Bonferroni correction, one of which showed reduced risk for the var allele (OR 0.61, 95% CI 0.45-0.82). The remaining four indicated increased risk for the wt allele where the chronic rejection (OR 2.10, 95% CI 1.36-3.24) and Indian (OR 1.44, 95% CI 1.13-1.84) subgroups were accorded susceptibility status. Conclusions: Risk associations for renal allograft rejection were increased and reduced on account of the wt and var alleles, respectively. These findings could render the VEGF polymorphisms useful in the clinical genetics of kidney transplantation.

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