scholarly journals Utility of radial endobronchial ultrasonography combined with transbronchial lung cryobiopsy in patients with diffuse parenchymal lung diseases: a multicentre prospective study

2021 ◽  
Vol 8 (1) ◽  
pp. e000826
Author(s):  
Minoru Inomata ◽  
Naoyuki Kuse ◽  
Nobuyasu Awano ◽  
Mari Tone ◽  
Hanako Yoshimura ◽  
...  
Keyword(s):  
Prospective Study ◽  
Bleeding Complications ◽  
Diffuse Parenchymal Lung Diseases ◽  
Diffuse Parenchymal Lung Disease ◽  
Endobronchial Ultrasonography ◽  
Transbronchial Lung Cryobiopsy ◽  
Reduce Risk ◽  
Parenchymal Lung Disease ◽  
Multicentre Prospective Study ◽  
Parenchymal Lung

BackgroundRadial endobronchial ultrasonography (R-EBUS) has been used in conjunction with transbronchial lung cryobiopsy (TBLC) to diagnose diffuse parenchymal lung disease (DPLD) and to decrease the risk of bleeding complications. The diagnostic utility of different R-EBUS signs, however, remains unknown.ObjectivesThis study aimed to determine whether different R-EBUS signs could be used to more accurately diagnose DPLD and whether bronchial bleeding could be prevented with use of R-EBUS during TBLC.MethodEighty-seven patients with DPLD were included in this multicentre prospective study, with 49 patients undergoing R-EBUS. R-EBUS signals were characterised as displaying either dense or blizzard signs. Pathological confidence of specimens obtained from TBLC was compared between patients with dense versus blizzard signs, and severity of bronchial bleeding was determined based on whether R-EBUS was performed or not.ResultsAll patients with dense signs on R-EBUS showed consolidation on high-resolution CT (HRCT) imaging. Pathological confidence of lung specimens was significantly higher in patients with dense signs versus those with blizzard signs (p<0.01) and versus those who did not undergo R-EBUS (p<0.05). Patients who underwent TBLC with R-EBUS were more likely to experience no or mild bronchial bleeding than patients who did not undergo R-EBUS (p<0.01), with shorter procedure times (p<0.01).ConclusionsThe dense R-EBUS sign corresponded with consolidation on HRCT. High-quality lung specimens may be obtainable when the dense sign is observed on R-EBUS, and R-EBUS combined with TBLC may reduce risk of bronchial bleeding and shorten procedure times.

scholarly journals Radial Endobronchial Ultrasonography with a Guide Sheath for the Diagnosis of Diffuse Parenchymal Lung Diseases

2019 ◽  
Author(s):  
Minoru Inomata ◽  
Naoyuki Kuse ◽  
Nobuyasu Awano ◽  
Mari Tone ◽  
Hanako Yoshimura ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Ground Glass Opacity ◽  
Tissue Samples ◽  
Ct Findings ◽  
Diffuse Parenchymal Lung Diseases ◽  
Diffuse Parenchymal Lung Disease ◽  
Endobronchial Ultrasonography ◽  
Parenchymal Lung Disease ◽  
Dense Pattern ◽  
Parenchymal Lung

Abstract Background Radial-endobronchial ultrasonography (R-EBUS) is a useful bronchoscopic tool for the diagnosis of solitary pulmonary peripheral lesions. However, the utility of R-EBUS for the diagnosis of diffuse parenchymal lung disease (DPLD) remains unclear. This study aimed to examine the characteristics of R-EBUS patterns in association with computed tomography (CT) findings in diagnosing DPLD. Methods Transbronchial lung biopsy (TBLB) was performed using R-EBUS and a guide sheath (GS) in consecutive 35 patients with suspected DPLD on chest CT between March–November 2017. Consolidation, ground glass opacity (GGO), reticular, and nodular patterns were diagnosed, and the mean CT Hounsfield units in the sampled area were measured in patients with consolidation. R-EBUS characteristics and their association with CT findings and pathological diagnostic yield were evaluated. Results R-EBUS showed a dense pattern only in patients with consolidation, and a blizzard pattern in patients with consolidation, GGO, reticular, and nodular patterns on CT. The biopsied area’s mean CT value was significantly higher in patients with dense than with blizzard patterns (p < 0.0001), and pathological findings were also dense in patients with R-EBUS dense pattern. The pathological diagnostic yield was significantly higher in patients with overt R-EBUS patterns than in patients without R-EBUS patterns by obtaining better lung tissue samples with the GS (p < 0.0001). Conclusions Dense and blizzard R-EBUS patterns were novel findings in diagnosing DPLD, and TBLB with R-EBUS-GS may be a valuable tool in diagnosing DPLD

scholarly journals Case Report of Diffuse Parenchymal Lung Disease with Non-Specific Interstitial Pneumonia Pattern and Good Response to Treatment

2019 ◽  
Vol 13 (2) ◽  
pp. 101-103
Author(s):  
Muhammad Asaduzzaman Biswas ◽  
Muhammad Nazrul Islam ◽  
Khalifa Mahmud Walid ◽  
Zhilam Zia Rassel
Keyword(s):  
Treatment Response ◽  
Interstitial Pneumonia ◽  
Lung Diseases ◽  
Young Female ◽  
Response To Treatment ◽  
Diffuse Parenchymal Lung Diseases ◽  
Diffuse Parenchymal Lung Disease ◽  
Pulmonary Parenchyma ◽  
Parenchymal Lung Disease ◽  
Parenchymal Lung

The diffuse parenchymal lung diseases (DPLDs) are a heterogeneous group of conditions affecting the pulmonary parenchyma (interstitial) and/or alveolar lumen. IPF (Idiopathic Pulmonary Fibrosis) is a chronic interstitial pneumonia of unknown causes. It is commonest form of DPLD but its treatment response is very poor. On the other hand, NSIP (Non-Specific Interstitial Pneumonia) can still be a variant of DPLD with better treatment response and prognosis. Here we discussed a young female with NSIP with good response to steroid. Faridpur Med. Coll. J. Jul 2018;13(2): 101-103

scholarly journals Diffusion lung capacity for carbon monoxide correlates with HRCT findings in patients with diffuse parenchymal lung disease

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Ezzelregal G. Hieba ◽  
Eldiasty E. Shaimaa ◽  
Sheha S. Dina ◽  
Ahmed O. Noha
Keyword(s):  
Carbon Monoxide ◽  
Pulmonary Function ◽  
Lung Diseases ◽  
Fibrosis Score ◽  
Lung Capacity ◽  
Diffuse Parenchymal Lung Diseases ◽  
Diffuse Parenchymal Lung Disease ◽  
Parenchymal Lung Disease ◽  
Parenchymal Lung

Abstract Diffusion lung capacity for carbon monoxide correlates with HRCT findings in patients with diffuse parenchymal lung disease. Background Diffuse parenchymal lung diseases (DPLDs) affect the alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. High-resolution computed tomography (HRCT) of the chest is the gold standard modality for diagnosing DPLD. Pulmonary function tests usually show a restrictive defect in spirometry. Single breath diffusion lung capacity for carbon monoxide (DLCO-SB) technique is used to assess the diffuse parenchymal lung diseases, as there is thickening of the alveolar membrane and diminished total lung capacity due to interstitial processes with severe decline in the transfer factor. The aim of this work was to correlate between Warrick’s HRCT fibrosis score and DLCO-SB in DPLD and to assess the possibility of using DLCO as an only tool to follow up DPLD to avoid repeated radiation exposure of the patients in HRCT chest (decrease need for radiological follow-up) or vice versa. Results This work recruited 89 patients over a period of 10 months duration, 74.2% of them were females. The Warrick’s score, ground-glass opacity, irregular pleural margin, subpleural cyst, honeycombing, and septal and subpleural lines were represented as 96.6%, 70.8%, 55.1%, 49.4%, and 48.3% respectively in HRCT of DPLD. Warrick’s score and its subscores (severity score, extent score, alveolitis score, and fibrosis score) were associated with a highly significant decrease in different pulmonary function indices (FVC, FEV1, TLC, and DLCO) with P value 0.001. A highly significant correlation between DLCO grades and total score grades was found with P value 0.001, and 86.8% of the patients with severe DLCO affection showed severe degree of total fibrosis score. Conclusions Both DLCO-SB and HRCT fibrosis scores were significantly correlated. Lifelong follow-up of function and structure of the lung in DPLD is needed by HRCT and DLCO. In an attempt to minimize repeated radiation exposure and reduce cost, we suggest DLCO to be used alone for longer follow-up periods rather than HRCT chest.

scholarly journals Clinical Patterns of Diffuse Parenchymal Lung Disease in Kuwait: A Prospective Study

2004 ◽  
Vol 13 (2) ◽  
pp. 78-83 ◽  
Author(s):  
A. Abul ◽  
B.O. Onadeko ◽  
M.E. Khadadah ◽  
N. Behbehani ◽  
M. Cerna ◽  
...  
Keyword(s):  
Prospective Study ◽  
Lung Disease ◽  
Diffuse Parenchymal Lung Disease ◽  
Clinical Patterns ◽  
A Prospective Study ◽  
Parenchymal Lung Disease ◽  
Parenchymal Lung

ProSP-B as a potential biomarker in diffuse parenchymal lung disease (DPLD)

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
N Kahn ◽  
A Rossler ◽  
K Hornemann ◽  
T Muley ◽  
A Warth ◽  
...  
Keyword(s):  
Lung Disease ◽  
Potential Biomarker ◽  
Diffuse Parenchymal Lung Disease ◽  
Parenchymal Lung Disease ◽  
Parenchymal Lung
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