scholarly journals 54 Sleep spindles as a biomarker for alpha-synucleinopathies in Rapid eye movement (REM) behaviour disorder (RBD)

2021 ◽  
Author(s):  
Eilidh McMillan ◽  
Stevie Williams ◽  
Renata Riha
Keyword(s):  
Eye Movement ◽  
Sleep Spindles ◽  
Rapid Eye Movement ◽  
Behaviour Disorder

scholarly journals Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder

2021 ◽  
Vol 20 (8) ◽  
pp. 671-684
Author(s):  
Mitchell G Miglis ◽  
Charles H Adler ◽  
Elena Antelmi ◽  
Dario Arnaldi ◽  
Luca Baldelli ◽  
...  
Keyword(s):  
Eye Movement ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour

scholarly journals Nonrapid eye movement sleep electroencephalographic oscillations in idiopathic rapid eye movement sleep behavior disorder: a study of sleep spindles and slow oscillations

SLEEP ◽  
2020 ◽  
Author(s):  
Jun-Sang Sunwoo ◽  
Kwang Su Cha ◽  
Jung-Ick Byun ◽  
Jin-Sun Jun ◽  
Tae-Joon Kim ◽  
...  
Keyword(s):  
Eye Movement ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Nrem Sleep ◽  
Sleep Spindles ◽  
Rapid Eye Movement ◽  
Sleep Behavior ◽  
Slow Oscillations ◽  
Lower Amplitude

Abstract Study Objectives We investigated electroencephalographic (EEG) slow oscillations (SOs), sleep spindles (SSs), and their temporal coordination during nonrapid eye movement (NREM) sleep in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). Methods We analyzed 16 patients with video-polysomnography-confirmed iRBD (age, 65.4 ± 6.6 years; male, 87.5%) and 10 controls (age, 62.3 ± 7.5 years; male, 70%). SSs and SOs were automatically detected during stage N2 and N3. We analyzed their characteristics, including density, frequency, duration, and amplitude. We additionally identified SO-locked spindles and examined their phase distribution and phase locking with the corresponding SO. For inter-group comparisons, we used the independent samples t-test or Wilcoxon rank-sum test, as appropriate. Results The SOs of iRBD patients had significantly lower amplitude, longer duration (p = 0.005 for both), and shallower slope (p < 0.001) than those of controls. The SS power of iRBD patients was significantly lower than that of controls (p = 0.002), although spindle density did not differ significantly. Furthermore, SO-locked spindles of iRBD patients prematurely occurred during the down-to-up-state transition of SOs, whereas those of controls occurred at the up-state peak of SOs (p = 0.009). The phase of SO-locked spindles showed a positive correlation with delayed recall subscores (p = 0.005) but not with tonic or phasic electromyography activity during REM sleep. Conclusions In this study, we found abnormal EEG oscillations during NREM sleep in patients with iRBD. The impaired temporal coupling between SOs and SSs may reflect early neurodegenerative changes in iRBD.

scholarly journals Rapid eye movement sleep behaviour disorder, depression and cognitive impairment. Case study

2000 ◽  
Vol 176 (2) ◽  
pp. 189-192 ◽  
Author(s):  
Nicholas A. Clarke ◽  
Adrian J. Williams ◽  
Michael D. Kopelman
Keyword(s):  
Cognitive Impairment ◽  
Eye Movement ◽  
Rem Sleep ◽  
Neuropsychological Testing ◽  
Brain Mri ◽  
Diagnostic Category ◽  
Rapid Eye Movement ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

BackgroundRapid eye movement (REM) sleep behaviour disorder is a relatively new diagnostic category. It has never before been associated with a treatable depressive condition.AimsTo repot on a 74-year-old man with a history of depression and REM sleep behaviour disorder, associated with mild cognitive impairment.MethodAssessment using brain CT, MRI, PET, electroencephalography, neuropsychological testing and nocturnal polysomnography.ResultsDepression was treated with sertraline. Sleep laboratory studies supported a diagnosis of REM sleep behaviour disorder, which was treated with clonazepam. Sleep apnoea, revealed later, was treated with nasal continuous positive airways pressure. Brain MRI showed mild atrophy, but neuropsychological testing indicated no progressive cognitive deterioration.ConclusionsThis case draws attention to REM sleep behaviour disorder and its potential interaction with depression and cognitive impairment, producing symptoms which can be mistaken for early dementia. The diagnosis of REM sleep behaviour disorder is easily missed, and it requires careful history-taking and sleep investigation in all suspected sufferers. Associated neurological, sleep and psychiatric conditions (including depression and cognitive impairment) may confound the diagnosis.

scholarly journals Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder

2018 ◽  
Vol 115 ◽  
pp. 9-16 ◽  
Author(s):  
Morten Gersel Stokholm ◽  
Alex Iranzo ◽  
Karen Østergaard ◽  
Mónica Serradell ◽  
Marit Otto ◽  
...  
Keyword(s):  
Eye Movement ◽  
Microglial Activation ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour

scholarly journals Clinical and video-polysomnographic analysis of rapid eye movement sleep behavior disorder and other sleep disturbances in dementia with Lewy bodies

SLEEP ◽  
2019 ◽  
Vol 42 (7) ◽  
Author(s):  
Ana Fernández-Arcos ◽  
Estrella Morenas-Rodríguez ◽  
Joan Santamaria ◽  
Raquel Sánchez-Valle ◽  
Albert Lladó ◽  
...  
Keyword(s):  
Eye Movement ◽  
Rem Sleep ◽  
Predictive Value ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Behavior Disorder ◽  
Sleep Spindles ◽  
Electromyographic Activity ◽  
Rapid Eye Movement ◽  
Sleep Behavior

Abstract Objective The main objective of this study was to study rapid eye movement (REM) sleep behavior disorder (RBD) and other sleep disorders in dementia with Lewy bodies (DLB). Methods Consecutive patients with DLB and mild dementia severity were recruited irrespective of sleep complaints. Patients underwent clinical interview, assessment of sleep scales, and video-polysomnography (V-PSG). RBD was diagnosed with V-PSG based on electromyographic and audiovisual analysis. Results Thirty-five patients (65.7% men; mean age 77.7 ± 6.1 years) were evaluated. Poor sleep quality (54.3%), hypersomnia (37.1%), snoring (60%), and abnormal nocturnal behaviors (77.1%) were reported. Sleep–wake architecture abnormalities occurred in 75% patients and consisted of occipital slowing on awake electroencephalography (EEG; 34.4%), the absence of sleep spindles and K complexes (12.9%), slow frequency sleep spindles (12.9%), delta activity in REM sleep (19.2%), and REM sleep without atonia (44%). Three patients showed hallucinatory-like behaviors and 10 patients showed abnormal behaviors during arousals mimicking RBD. RBD was diagnosed in 50% of those patients in whom sufficient REM sleep was attained. Of these, 72.7% were not aware of displaying dream-enacting behaviors and in 63.7% RBD preceded the onset of cognitive impairment. For RBD diagnosis, the sensitivity of Mayo Sleep Questionnaire was 50%, specificity was 66.7%, positive predictive value was 83.3%, and negative predictive value was 28%. False-positive RBD cases according to clinical history had hallucinatory-like behaviors, severe obstructive sleep apnea, and prominent periodic limb movements in sleep. Occipital EEG frequency while awake and rate of electromyographic activity in REM sleep were negatively correlated, suggesting a common subcortical origin. Conclusion In DLB, RBD and sleep–wake disorders are common, heterogeneous, and complex, challenging their identification without performing V-PSG.

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