More evidence on prophylactic low-dose heparin

1974 ◽  
Vol 12 (15) ◽  
pp. 57-59
Keyword(s):  
Deep Vein Thrombosis ◽  
Preliminary Data ◽  
Mode Of Action ◽  
Low Dose ◽  
Fractured Neck Of Femur ◽  
Neck Of Femur ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Deep Vein ◽  
Low Dose Heparin

Nearly 2 years ago we discussed the use of low-dose subcutaneous heparin1 and concluded that this drug in doses of 5000 units 1 or 2 hours before operation and then 12-hourly, lowers the incidence of deep-vein thrombosis after most major operations, other than those for fractured neck of femur. Haemorrhage is not a serious problem. More is now known about the mode of action of heparin; further studies on the prevention of deep-vein thrombosis have been published; and preliminary data are available on the effect of low-dose heparin on the incidence of post-operative embolism.

Low-Dose Heparin and Deep-Vein Thrombosis after Total Hip Replacement

1976 ◽  
Vol 36 (01) ◽  
pp. 157-164 ◽  
Author(s):  
P. M Mannucci ◽  
Luisa E. Citterio ◽  
N Panajotopoulos
Keyword(s):  
Deep Vein Thrombosis ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Low Dose ◽  
Control Group ◽  
Total Hip ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Deep Vein ◽  
Low Dose Heparin

SummaryThe effect of subcutaneous low-dose heparin on postoperative deep-vein thrombosis (D. V. T.) (diagnosed by the 125I-labelled fibrinogen test) has been investigated in a trial of 143 patients undergoing the operation of total hip replacement. Two randomized studies were carried out: in one the scanning for D.V.T. was carried out daily for 7 days post operatively and in the other for 15 days. In both, the incidence of D.V.T. was significantly lower in the heparin-treated patients (P<0.005). Bilateral D.V.T. was also prevented (P<0.05), through the extension of D.V.T. to the distal veins of the thigh was not significantly reduced. Heparin treatment was, however, followed by a higher incidence of severe postoperative bleeding (P< 0.02) and wound haematoma formation (P< 0.005), and the postoperative haemoglobin was significantly lower than in the control group (P<0.005). A higher number of transfused blood units was also needed by the heparin treated patients (P<0.001).

The Prophylaxis of Deep Vein Thrombosis with Low-Dose Heparin: A Trial

1974 ◽  
Vol 44 (3) ◽  
pp. 289-291 ◽  
Author(s):  
J. Propsting ◽  
O. Williams ◽  
M. Stathis ◽  
J. F. Mccaffrey
Keyword(s):  
Deep Vein Thrombosis ◽  
Low Dose ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Deep Vein ◽  
Low Dose Heparin

LOW-DOSE HEPARIN PROPHYLAXIS AGAINST DEEP-VEIN THROMBOSIS AFTER ACUTE STROKE

The Lancet ◽  
1978 ◽  
Vol 311 (8056) ◽  
pp. 160-161
Author(s):  
O.J.S. Buruma ◽  
A.R. Wintzen ◽  
E. Briët
Keyword(s):  
Deep Vein Thrombosis ◽  
Acute Stroke ◽  
Low Dose ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Deep Vein ◽  
Low Dose Heparin ◽  
Heparin Prophylaxis

Low-Dose Heparin in Proximal Femoral Fractures:Failure to Prevent Deep-Vein Thrombosis

1981 ◽  
Vol 52 (1) ◽  
pp. 77-80 ◽  
Author(s):  
H. Svend-Hansen ◽  
V. Bremerskov ◽  
J. Gøtrich ◽  
P. Ostri
Keyword(s):  
Deep Vein Thrombosis ◽  
Low Dose ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Deep Vein ◽  
Low Dose Heparin

Randomized study of adjusted versus fixed low dose heparin prophylaxis of deep vein thrombosis in hip surgery

1989 ◽  
Vol 76 (9) ◽  
pp. 933-935 ◽  
Author(s):  
D. A. Taberner ◽  
L. Poller ◽  
J. M. Thomson ◽  
G. Lemon ◽  
F. J. Weighill
Keyword(s):  
Deep Vein Thrombosis ◽  
Low Dose ◽  
Randomized Study ◽  
Hip Surgery ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Deep Vein ◽  
Low Dose Heparin ◽  
Heparin Prophylaxis

Peri-operative low-dose heparin

1982 ◽  
Vol 20 (2) ◽  
pp. 5-7
Keyword(s):  
Deep Vein Thrombosis ◽  
General Surgery ◽  
Low Dose ◽  
Lung Perfusion ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Perfusion Studies ◽  
Deep Vein ◽  
Low Dose Heparin ◽  
Major General

Many trials have now shown that low-dose heparin reduces the incidence of deep-vein thrombosis.1,2 In addition evidence from lung-perfusion studies suggests that such prophylaxis will also reduce the 1% mortality normally associated with major general surgery.3,4

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