Topical corticosteroids in ulcerative colitis

1975 ◽  
Vol 13 (2) ◽  
pp. 5-7
Keyword(s):  
Ulcerative Colitis ◽  
Corticosteroid Therapy ◽  
Systemic Corticosteroid ◽  
Extensive Disease ◽  
Double Blind ◽  
Topical Corticosteroids ◽  
Systemic Corticosteroid Therapy ◽  
Blind Trials

Since the usefulness of topical corticosteroids in the treatment of ulcerative colitis was first reported1 double-blind trials have confirmed their effectiveness, and they are now widely used.2 For disease localised to the rectum suppositories, and for more extensive disease, retention enemas containing various corticosteroids are available (see table). In severe cases these preparations also valuably supplement systemic corticosteroid therapy, with or without sulphasalazine (Salazopyrin).

scholarly journals Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis

2021 ◽  
Vol 6 (4) ◽  
pp. 218-224
Author(s):  
Katsuya Endo ◽  
Tomonori Satoh ◽  
Yuki Yoshino ◽  
Shiho Kondo ◽  
Yoko Kawakami ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Multivariate Analysis ◽  
Corticosteroid Therapy ◽  
Systemic Corticosteroid ◽  
Predictive Biomarkers ◽  
Mayo Score ◽  
Therapeutic Outcomes ◽  
Independent Risk Factors ◽  
Systemic Corticosteroid Therapy

<b><i>Introduction:</i></b> Predictive biomarkers for the therapeutic outcome of induction therapy with systemic corticosteroid for active ulcerative colitis (UC) have not been established. This study aimed to investigate whether neutrophil-to-lymphocyte ratio (NLR) and/or platelet-to-lymphocyte ratio (PLR) can be predictive biomarkers for the therapeutic outcomes of systemic corticosteroid therapy in UC. <b><i>Methods:</i></b> This was a single-center retrospective cohort study. In total, 48 patients with UC who received induction therapy with systemic corticosteroid were enrolled. Based on the achievement of clinical remission after 8 weeks of treatment, the patients were divided into the remission group (<i>n</i> = 28) and the nonremission group (<i>n</i> = 20). Clinical characteristics, NLR, and PLR at baseline between the remission and nonremission groups were compared via a univariate analysis. The independent risk factors of nonremission were identified via a multivariate analysis. <b><i>Results:</i></b> The baseline Mayo score, platelet count, lymphocyte count, C-reactive protein (CRP) levels, NLR, and PLR between the 2 groups significantly differed. The nonremission group had higher NLR and PLR than the remission group (4.70 [3.04–11.3] vs. 3.10 [1.36–16.42]; <i>p</i> &#x3c; 0.05, and 353.6 [220.3–499.8] vs. 207.2 [174.4–243.6]; <i>p</i> &#x3c; 0.001, respectively). A multivariate analysis revealed that a Mayo score of ≥9, CRP level of ≥1.26 mg/dL, and PLR of ≥262 (hazard ratio: 23.1, 95% confidence interval: 1.29–413.7, <i>p</i> = 0.033) were considered independent risk factors for nonremission. <b><i>Conclusion:</i></b> This report first identified the efficacy of NLR and PLR as candidate biomarkers for predicting the therapeutic outcomes of systemic corticosteroid therapy in UC.

Systemic corticosteroid therapy of ulcerative colitis

1985 ◽  
Vol 89 (5) ◽  
pp. 1189-1191 ◽  
Author(s):  
Samuel Meyers ◽  
Henry D. Janowitz
Keyword(s):  
Ulcerative Colitis ◽  
Corticosteroid Therapy ◽  
Systemic Corticosteroid ◽  
Systemic Corticosteroid Therapy

Successful Management with Systemic Corticosteroid Therapy for a Case of Diffuse Neonatal Hemangiomatosis

2003 ◽  
Vol 65 (3) ◽  
pp. 244-248
Author(s):  
Shinako KANAMORI ◽  
Takeo AOKI ◽  
Chiaki OHBA ◽  
Shigeo NONAKA
Keyword(s):  
Corticosteroid Therapy ◽  
Systemic Corticosteroid ◽  
Successful Management ◽  
Systemic Corticosteroid Therapy

scholarly journals Development of uveitis during systemic corticosteroid therapy in TINU syndrome

2011 ◽  
Vol 26 (7) ◽  
pp. 1177-1178 ◽  
Author(s):  
Sebastiano A. G. Lava ◽  
Oliver Bucher ◽  
Barbara S. Bucher ◽  
Giacomo D. Simonetti ◽  
Sibylle Tschumi
Keyword(s):  
Corticosteroid Therapy ◽  
Systemic Corticosteroid ◽  
Tinu Syndrome ◽  
Systemic Corticosteroid Therapy
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