Domperidone - a new anti-emetic
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Domperidone (Motilium - Janssen), like metoclopramide (Maxolon, Primperan),1 is a dopamine receptor antagonist. The anti-emetic properties of both drugs are due to two actions: a central one on the chemoreceptor trigger zone (which is functionally outside the blood-brain barrier) and a peripheral action on gastro-intestinal motility and on the lower oesophageal sphincter. The manufacturer claims that as domperidone does not penetrate to the basal ganglia it causes fewer dystonic reactions than metoclopramide. A detailed review has been published.2
1999 ◽
Vol 30
(2)
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pp. 263-268
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2020 ◽
Vol 117
(20)
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pp. 11085-11096
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1993 ◽
Vol 31
(3-4)
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pp. 305-310
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2002 ◽
Vol 335
(8)
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pp. 367-373
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