Medical treatment of gallstones: ursodeoxycholic acid

1984 ◽  
Vol 22 (4) ◽  
pp. 13-15
Keyword(s):  
Medical Treatment ◽  
Ursodeoxycholic Acid ◽  
Chenodeoxycholic Acid ◽  
Cholesterol Gallstones ◽  
Dissolution Of Gallstones

We discussed the dissolution of gallstones with chenodeoxycholic acid (CDCA) (Chendol - CP Pharmaceuticals; Chenofalk - Thames) five years ago.1 Now a second drug, ursodeoxycholic acid (UDCA) (Destolit - Merrell; Ursofalk - Thames) is available for the same purpose. Like CDCA it is given by mouth to dissolve non-calcified cholesterol gallstones in the gallbladder. Several potential advantages are claimed for UDCA; what is its place in treatment?

Rowachol for gallstone dissolution?

1985 ◽  
Vol 23 (19) ◽  
pp. 75-76
Keyword(s):  
Combination Therapy ◽  
Ursodeoxycholic Acid ◽  
Chenodeoxycholic Acid ◽  
Common Duct ◽  
Cholesterol Gallstones ◽  
Gallstone Dissolution ◽  
The Common

Rowachol (Tillotts) is a mixture of monoterpenes intended for the dissolution of cholesterol gallstones, as an adjunct to the existing drugs chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) whose use we discussed last month.1 When combined with CDCA, Rowachol is claimed to dissolve stones in the common duct. This article assesses its efficacy both alone and in combination therapy.

The Medical Treatment of Cholesterol Gallstones: Experience with Chenodeoxycholic Acid

Digestion ◽  
1976 ◽  
Vol 14 (3) ◽  
pp. 209-219 ◽  
Author(s):  
L. Barbara ◽  
E. Roda ◽  
A. Roda ◽  
C. Sama ◽  
D. Festi ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Chenodeoxycholic Acid ◽  
Cholesterol Gallstones

A scanning electron microscopic study on dissolving process of cholesterol gallstones by chenodeoxycholic acid (CDCA)

1978 ◽  
Vol 36 (2) ◽  
pp. 522-523
Author(s):  
T. Kanetaka ◽  
M. Cho ◽  
S. Kawamura ◽  
T. Sado ◽  
K. Hara
Keyword(s):  
Electron Microscope ◽  
Chenodeoxycholic Acid ◽  
Outer Surface ◽  
Electron Microscopic ◽  
Cholesterol Gallstones ◽  
The Core ◽  
Scanning Electron Microscopic Study ◽  
Scanning Electron Microscopic ◽  
Acceleration Voltage ◽  
Scanning Electron

The authors have investigated the dissolution process of human cholesterol gallstones using a scanning electron microscope(SEM). This study was carried out by comparing control gallstones incubated in beagle bile with gallstones obtained from patients who were treated with chenodeoxycholic acid(CDCA).The cholesterol gallstones for this study were obtained from 14 patients. Three control patients were treated without CDCA and eleven patients were treated with CDCA 300-600 mg/day for periods ranging from four to twenty five months. It was confirmed through chemical analysis that these gallstones contained more than 80% cholesterol in both the outer surface and the core.The specimen were obtained from the outer surface and the core of the gallstones. Each specimen was attached to alminum sheet and coated with carbon to 100Å thickness. The SEM observation was made by Hitachi S-550 with 20 kV acceleration voltage and with 60-20, 000X magnification.

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