Nasal ventilation in acute exacerbations of chronic obstructive pulmonary disease: effect of ventilator mode on arterial blood gas tensions.

Background: The outcome of Chronic Obstructive Pulmonary Disease depends upon the partial pressure of oxygen and carbon dioxide This study was aimed to find the role of arterial blood gas parameters during the length of hospital stay among patients admitted for Chronic Obstructive Pulmonary Diseasewith acute exacerbation. Materials and Methods: This was an observational study conducted in KIST Medical College Teaching Hospital from February 2017 to August 2019. Patients admitted with the chronic obstructive pulmonary disease were evaluated. Demographic data as well as oxygen saturation (SPO2), pulmonary function test, and arterial blood gas analysis were recorded and analyzed. Results: Among 112 patients, the female to male ratio was 1.38: 1 with 84.8% over 60 years of age. One-third of patients (n=38) had exposure to both tobacco smoking and biomass and of them, 86.8% were females. Mean SpO2 was 75.9% and mean FEV1 was 0.92 L (SD=0.295) and significant association was found (p<0.001) between them. Furthermore, 70 (62.5%) patients had type I respiratory failure and 42 patients (37.5%) had type II respiratory failure. Patients with type II respiratory failure and hypercapnic patients had prolonged hospital stay with significant p-value (p<0.001). Similarly, significance was observed in the p-value for acidic blood pH, which was <0.05. Conclusions: Increased length of hospital stay is seen in patients with acute exacerbation of Chronic Obstructive Pulmonary Disease with type II respiratory failure. Hence, aggressive early management to correct hypercapnia may lead to decreased hospital stay along with a better outcome. Thus hypercapnia should be considered as one of the important criteria to flag the patient and manage accordingly.

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Correlation of Arterial blood gas value in outcome of patient admitted with acute exacerbation of Chronic Obstructive Pulmonary Disease

10.21203/rs.3.rs-26704/v1 ◽

2020 ◽

Author(s):

Santosh Gautam ◽

Shiva Raj K C ◽

Milesh Jung Sijapati ◽

Purnima Gyawali ◽

Geetika KC ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Respiratory Failure ◽

Hospital Stay ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Type Ii ◽

Blood Gas ◽

Obstructive Pulmonary Disease ◽

Arterial Blood Gas ◽

Arterial Blood

Abstract Introduction: The outcome of Chronic Obstructive Pulmonary Disease depends upon the partial pressure of oxygen and carbon dioxide This study was aimed to find the role of arterial blood gas parameters during the length of hospital stay among patients admitted for COPD with acute exacerbation. Materials and Methods: This was an observational study conducted in KIST Medical College Teaching Hospital from February 2017 to August 2019. Patients admitted with chronic obstructive pulmonary disease were evaluated. Demographic data as well as SPO2, pulmonary function test, and arterial blood gas analysis were recorded and analyzed. Results: Among 112 patients, the female to male ratio was 1.38: 1 with 84.8% over 60 years of age. One-third of patients (n = 38) had exposure to both tobacco smoking and biomass and of them, 86.8% were females. Mean SpO2 was 75.9% and mean FEV1 was 0.92 L (SD = 0.295) and significant association was found (p < 0.001) between them. Furthermore, 70 (62.5%) patients had type I respiratory failure and 42 patients (37.5%) had type II respiratory failure. Patients with type II respiratory failure and hypercapnic patients had prolonged hospital stay with significant p-value (p < 0.001). Similarly, significance was observed in the p-value for blood pH, which was < 0.05. Conclusions: Increased length of hospital stay is seen in patients with AECOPD with type II respiratory failure. Hence, aggressive early management to correct hypercapnia may lead to decreased hospital stay along with a better outcome. Thus hypercapnia should be considered as one of the important criteria to flag the patient and manage accordingly.

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Relationship between arterial blood gases and spirometry in acute exacerbations of chronic obstructive pulmonary disease

Annals of Emergency Medicine ◽

10.1016/s0196-0644(89)80837-6 ◽

1989 ◽

Vol 18 (5) ◽

pp. 523-527 ◽

Cited By ~ 33

Author(s):

Charles L Emerman ◽

Alfred F Connors ◽

Thomas W Lukens ◽

David Effron ◽

Michael E May

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Blood Gases ◽

Chronic Obstructive ◽

Arterial Blood Gases ◽

Obstructive Pulmonary Disease ◽

Arterial Blood ◽

Acute Exacerbations

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Chinese Herbal Medicine (WeijingDecoction) Combined with Pharmacotherapy for the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/257012 ◽

2014 ◽

Vol 2014 ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Shaonan Liu ◽

Johannah Shergis ◽

Xiankun Chen ◽

Xuhua Yu ◽

Xinfeng Guo ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Blood Gases ◽

Effective Rate ◽

Forced Expiratory Volume ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Randomized Controlled ◽

Arterial Blood ◽

Acute Exacerbations

Objective. To evaluate the efficacy and safety ofWeijingdecoction combined with routine pharmacotherapy (RP) for the treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods. Randomized controlled trials (RCT) evaluatingWeijingdecoction for AECOPD were included. English, Chinese, and Japanese databases were searched from their respective inceptions to June 2013. The methodological quality was assessed according to the Cochrane Collaboration’s risk of bias tool. All data were analyzed and synthesized using RevMan 5.2 software.Results. Fifteen (15) studies involving 986 participants were included. Participants were diagnosed with COPD in the acute exacerbation stage. In addition, most of studies reported that they included participants with the Chinese medicine syndrome, phlegm-heat obstructing the Lung.Weijingdecoction combined with RP improved lung function (forced expiratory volume in one second; FEV1), arterial blood gases (PaO2 and PaCO2), clinical effective rate, and reduced inflammatory biomarkers (TNF-αand IL-8) when compared with RP alone. No severe adverse events were reported in these studies.Conclusions.Weijingdecoction appeared to be beneficial for AECOPD and well-tolerated when taken concurrently with RP, such as antibiotics, bronchodilators (oral and inhaled), and mucolytics.

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Association of Serum Magnesium Levels with Frequency of Acute Exacerbations in Chronic Obstructive Pulmonary Disease: A Prospective Study

Pulmonary Medicine ◽

10.1155/2014/329476 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 7

Author(s):

Aziz Gumus ◽

Muge Haziroglu ◽

Yilmaz Gunes

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Pulmonary Function Tests ◽

Serum Magnesium ◽

Magnesium Level ◽

Chronic Obstructive ◽

Serum Magnesium Level ◽

Obstructive Pulmonary Disease ◽

Arterial Blood ◽

Acute Exacerbations

Background. The course of chronic obstructive pulmonary disease (COPD) is accompanied by acute exacerbations. The purpose of this study is to determine the association of serum magnesium level with acute exacerbations in COPD (COPD-AE).Materials and Methods. Eighty-nine patients hospitalized with COPD-AE were included. Hemogram, biochemical tests, and arterial blood gases were analyzed. Pulmonary function tests were performed in the stable period after discharge. Patients were followed up at 3 monthly periods for one year.Results. Mean age of the patients was70.4±7.8(range 47–90) years. Mean number of COPD-AE during follow-up was4.0±3.6(range 0–15). On Spearman correlation analysis there were significant negative correlations between number of COPD-AE and predicted FEV1% (P=0.001), total protein (P=0.024), globulin (P=0.001), creatinine (P=0.001), and uric acid levels (P=0.036). There were also significant positive correlations between number of COPD-AE and serum magnesium level (P<0.001) and platelet count (P=0.043). According to linear regression analysis predicted FEV1% (P=0.011), serum magnesium (P<0.001), and globulin (P=0.006) levels were independent predictors of number of COPD-AE.Conclusions. In this small prospective observational study we found that serum magnesium level during exacerbation period was the most significant predictor of frequency of COPD-AE.

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