Increased lipoprotein lipase activity of skeletal muscle in cold-acclimated rats

1977 ◽  
Vol 55 (12) ◽  
pp. 1241-1243 ◽  
Author(s):  
N. Bégin-Heick ◽  
H. M. C. Heick
Keyword(s):  
Skeletal Muscle ◽  
Cold Acclimation ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Skeletal Muscles ◽  
Lipoprotein Lipase Activity ◽  
Slow Twitch ◽  
Respiratory Movements ◽  
Parallel Fashion

The activity of lipoprotein lipase (LPL) in the heart, diaphragm, and soleus muscles was markedly increased in cold-acclimated rats and it was even greater in rats treated with oxytetracycline (OTC) while exposed to cold. Other skeletal muscles studied had low and variable activities which were not significantly increased by cold acclimation or by cold plus OTC treatment. It appears therefore that, apart from the heart and the muscles involved in respiratory movements, LPL activity is primarily associated with those muscles which contain a predominance of slow-twitch oxidative fibers, and that the enzyme in muscle, heart, and diaphragm responds to cold acclimation and cold plus OTC treatment in a parallel fashion in these tissues.

Effect of exercise on lipoprotein lipase activity in rat heart and skeletal muscle

1975 ◽  
Vol 229 (2) ◽  
pp. 394-397 ◽  
Author(s):  
J Borensztajn ◽  
MS Rone ◽  
SP Babirak ◽  
JA McGarr ◽  
LB Oscai
Keyword(s):  
Skeletal Muscle ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Plasma Triglyceride ◽  
Treadmill Running ◽  
Muscle Fiber Types ◽  
Fiber Types ◽  
Lipoprotein Lipase Activity ◽  
Slow Twitch ◽  
Fast Twitch

Lipoprotein lipase activity was measured in the three skeletal muscle fiber types of untrained rats and in those of rats subjected to a 12-wk program of treadmill running. Lipoprotein lipase activity in slow-twitch red fibers was approximately 14- to 20-fold higher (P less than 0.001) than that in fast-twitch white and approximately 2-fold higher (P less than 0.001) than that in fast-twitch red fibers in the untrained animals. These results suggest that, in sedentary animals, mainly slow-twitch red and fast-twitch red fibers are capable of taking up plasma triglyceride fatty acids. Regularly performed endurance exercise resulted in significant increase (2- to 4.5-fold) in lipoprotein lipase activity in the three muscle fiber types examined. The increase in lipoprotein lipase activity in response to treadmill running suggests that exercise increases the capacity of these fibers to take up and oxidize plasma triglyceride fatty acids. Cardiac muscle did not undergo an exercise-induced increase in the levels of activity of lipoprotein lipase similar to that seen in skeletal muscle.

Lipoprotein lipase and uptake of chylomicron triglyceride by skeletal muscle of rats

1976 ◽  
Vol 231 (3) ◽  
pp. 860-864 ◽  
Author(s):  
C Linder ◽  
SS Chernick ◽  
TR Fleck ◽  
RO Scow
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Skeletal Muscles ◽  
Lipoprotein Lipase Activity ◽  
Triceps Brachii ◽  
Medial Head ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Chylomicron Triglyceride

Uptake of chylomicron triglyceride and lipoprotein lipase was studied in red and white skeletal muscles, heart, and adipose tissue of rats. Retention of triglyceride fatty acids 10 min after injection was 1.6%/g in heart and adipose tissue, 0.2-0.4%/g in red (soleus and diaphragm) muscles, and 0.1%/g in white (psoas minor) muscles of fed rats. Fasting (24 h) increased retention two- to fourfold in red skeletal muscles and heart, had no effect in white muscles, and decreased retention greater than 75% in adipose tissue. Lipoprotein lipase activity in fed rats was lowest in white muscles and in certain red (posterior belly of digastric and medial head of triceps brachii) musclws, intermediate in soleus and diaphragm muscles and adipose tissue, and highest in heart. Fasting doubled lipoprotein lipase activity in all red skeletal muscles and heart, had no effect in white muscles, and decreased activity 60% in adipose tissue. The findings indicate that triglyceride uptake is related to lipoprotein lipase activity in skeletal muscle and the changes in enzyme activity during fasting divert blood triglyceride to red skeletal muscles.

Serum Activation of Lipoprotein Lipase from Sheep Adipose Tissue

1985 ◽  
Vol 38 (1) ◽  
pp. 131
Author(s):  
RK Tume ◽  
RF Thornton
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Nutritional Restriction ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Increased Activity ◽  
Substrate Concentrations

The effects of species and plane of nutrition on serum activation of sheep adipose tissue lipoprotein lipase were studied over a range of substrate (triolein) concentrations. Serum, either from two species or from the same species on a different plane of nutrition, had differing effects on adipose tissue lipoprotein lipase activity. Serum from fed sheep was more effective than serum from fed rats in activating sheep adipose tissue lipoprotein lipase at low substrate concentrations. Serum taken from sheep on a restricted plane of nutrition, stimulated adipose tissue lipoprotein lipase activity at physiological substrate concentrations. The increased activity promoted by the factor(s) present in serum would ensure that those tissues (e.g. cardiac and skeletal muscle) which continue to synthesize lipoprotein lipase during fasting or nutritional restriction, are able to assimilate the relatively low amounts of circulating triacylglycerol.

Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: Relation to serum lipoproteins

Metabolism ◽  
1978 ◽  
Vol 27 (11) ◽  
pp. 1661-1671 ◽  
Author(s):  
Esko A. Nikkilä ◽  
Marja-Riitta Taskinen ◽  
Seppo Rehunen ◽  
Matti Härkönen
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Serum Lipoproteins

scholarly journals Effects of tri-iodothyronine administration on the disposal of oral [1-14C]triolein, lipoprotein lipase activity and lipogenesis in the rat during lactation and on removal of the litter

1994 ◽  
Vol 301 (2) ◽  
pp. 495-501 ◽  
Author(s):  
M Del Prado ◽  
T H Da Costa ◽  
D H Williamson
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Mammary Gland ◽  
Lipoprotein Lipase ◽  
White Adipose Tissue ◽  
Lipase Activity ◽  
Plasma Prolactin ◽  
Lipoprotein Lipase Activity ◽  
14Co2 Production ◽  
Pup Growth

The effect of tri-iodothyronine (T3) administration on the utilization of dietary [14C]lipid by the mammary gland and adipose tissue of lactating and litter-removed rats was studied. (1) After an oral load of [1-14C]triolein, the lactating rats treated with T3 (50 micrograms/100 g body wt.) over 24 h showed an increase in 14CO2 production and a decrease in the total [14C]lipid transferred through the mammary gland that was paralleled by a decrease in tissue lipoprotein lipase (LPL) activity. (2) T3 administration decreased plasma prolactin in the lactating rats. Prolactin replacement in T3-treated rats restored LPL activity in the mammary gland, but did not increase the amount of dietary [14C]lipid transferred to the milk. (3) Chronic T3 administration (4 days) to lactating rats did not affect pup growth or the lipogenic rate in the mammary gland. (4) The administration of T3 to litter-removed rats inhibited the increase of LPL activity in white adipose tissue and decreased the accumulation of dietary [14C]lipid. This decrease was accompanied by increased 14CO2 production and [14C]lipid accumulation in skeletal muscle and heart. (5) It is concluded that hyperthyroidism depresses LPL activity in mammary gland and white adipose tissue, but not in muscle. The increased accumulation of [14C]lipid in muscle and increased production of 14CO2 in lactating and in litter-removed rats treated with T3 is in part due to the decreased total LPL in mammary gland and adipose tissue respectively, which are therefore less able to compete with muscle for the available plasma triacylglycerols.

Sign in / Sign up

Export Citation Format

Share Document