The variability, arrangement, and rearrangement of immunoglobulin genes

1980 ◽  
Vol 58 (3) ◽  
pp. 176-187 ◽  
Author(s):  
T. H. Rabbitts ◽  
P. H. Hamlyn ◽  
G. Matthyssens ◽  
B. A. Roe
Keyword(s):  
Heavy Chain ◽  
Cdna Clone ◽  
Variable Region ◽  
Immunoglobulin Genes ◽  
Constant Region ◽  
Cross Hybridization ◽  
Heavy Chain Variable Region ◽  
Human Dna ◽  
V Genes

The multiplicity of heavy-chain variable-region (VH) genes in mouse and human DNA has been estimated using a mouse heavy- (H) chain cDNA clone. We found about 10 hybridization components in mouse DNA and about 20 components in human DNA. Cross-hybridization studies of variable region (V) genes indicate that these components represent the numbers of genes within the VH subgroups of each of these species. The arrangement and rearrangement of the H-chain γ subclasses have been studied in order to assess possible mechanisms of the H-chain switch. Evidence has been found for rearrangement events involving the γ2a and γ2b constant-region (CH) genes in DNA from cells making IgG2a and IgG2b respectively. In addition we found that cells making IgG2a lack detectable genes for γ1 and γ2b. Both sets of observations are discussed in relation to H-chain diversity and the switch.

scholarly journals The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region.

1993 ◽  
Vol 13 (3) ◽  
pp. 1547-1553 ◽  
Author(s):  
P Matthias ◽  
D Baltimore
Keyword(s):  
Transcription Factors ◽  
B Cell ◽  
Heavy Chain ◽  
Variable Region ◽  
Immunoglobulin Heavy Chain ◽  
Immunoglobulin Genes ◽  
Constant Region ◽  
Transcriptional Enhancer ◽  
Additional Control ◽  
Complex Regulation

The transcription of immunoglobulin genes is controlled by variable region promoters and by enhancers, both of which are lymphoid specific. Because immunoglobulin genes are subject to an extremely complex regulation, we anticipated that there might be additional control elements for these genes. We therefore sought additional enhancers and demonstrate here that there is indeed another weak transcriptional enhancer just 3' to the mouse alpha constant region. This novel immunoglobulin enhancer is lymphoid specific and at two positions can bind members of the Oct family of transcription factors.

The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region

1993 ◽  
Vol 13 (3) ◽  
pp. 1547-1553
Author(s):  
P Matthias ◽  
D Baltimore
Keyword(s):  
Transcription Factors ◽  
B Cell ◽  
Heavy Chain ◽  
Variable Region ◽  
Immunoglobulin Heavy Chain ◽  
Immunoglobulin Genes ◽  
Constant Region ◽  
Transcriptional Enhancer ◽  
Additional Control ◽  
Complex Regulation

The transcription of immunoglobulin genes is controlled by variable region promoters and by enhancers, both of which are lymphoid specific. Because immunoglobulin genes are subject to an extremely complex regulation, we anticipated that there might be additional control elements for these genes. We therefore sought additional enhancers and demonstrate here that there is indeed another weak transcriptional enhancer just 3' to the mouse alpha constant region. This novel immunoglobulin enhancer is lymphoid specific and at two positions can bind members of the Oct family of transcription factors.

Development of diagnostic antibodies against immunoglobulin heavy chain variable region for heavy chain amyloidosis (AH amyloidosis)

2021 ◽  
Vol 71 (4) ◽  
pp. 245-254
Author(s):  
Mayuko Nakagawa ◽  
Masahide Yazaki ◽  
Fuyuki Kametani ◽  
Nagaaki Katoh ◽  
Tsuneaki Yoshinaga ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Variable Region ◽  
Immunoglobulin Heavy Chain ◽  
Heavy Chain Variable Region

Heavy-chain variable-region sequence from an inulin-binding myeloma protein

Biochemistry ◽  
1977 ◽  
Vol 16 (6) ◽  
pp. 1170-1175 ◽  
Author(s):  
Mark Vrana ◽  
Stuart Rudikoff ◽  
Michael Potter
Keyword(s):  
Heavy Chain ◽  
Variable Region ◽  
Myeloma Protein ◽  
Heavy Chain Variable Region ◽  
Region Sequence
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