STEREOSPECIFIC SYNTHESIS OF A DIBENZO[a,g]QUINOLIZINE ANALOG OF 18-HYDROXYALLOYOHIMBANE

1965 ◽  
Vol 43 (9) ◽  
pp. 2545-2550
Author(s):  
B. Belleau ◽  
D. Dvornik
Keyword(s):  
Dicarboxylic Acid ◽  
Acid Ester ◽  
Stereospecific Synthesis ◽  
Synthetic Method ◽  
Pharmacological Properties

Starting from 4-cyclohexene-cis-1,2-dicarboxylic acid, the stereospecific synthesis of the dibenzo[a,g]quinolizine analog IV of epialloyohimbane is described. The synthetic method of approach is outlined in Chart 1. As the trimethoxybenzoic acid ester, the base IV proved to be devoid of significant pharmacological properties.

ChemInform Abstract: IMIDAZOLE-4,5-DICARBOXYLIC ACID DERIVATIVES, IV. IMIDAZOLE-4,5-DICARBOXYLIC ACID ESTER AMIDES AND DIAMIDES

1977 ◽  
Vol 8 (11) ◽  
pp. no-no
Author(s):  
H. SCHUBERT ◽  
S. HOFFMANN ◽  
V. UHLIG ◽  
H.-E. POLSTER ◽  
P. HELD ◽  
...  
Keyword(s):  
Dicarboxylic Acid ◽  
Acid Ester ◽  
Dicarboxylic Acid Ester

scholarly journals A simple route to a novel acid-sensitive 20( S )- O -linked camptothecin norcantharidin acid ester derivative

2018 ◽  
Vol 5 (2) ◽  
pp. 170842 ◽  
Author(s):  
Changkuo Zhao ◽  
Xianheng Wang ◽  
Fuhong Yang ◽  
Lei Gao ◽  
Yuhe Wang
Keyword(s):  
Acid Ester ◽  
Total Yield ◽  
High Yield ◽  
Synthetic Method ◽  
Synthetic Compound ◽  
Similar Activity ◽  
Simple Route ◽  
Ester Derivative ◽  
Tumour Cell Lines ◽  
Working Procedure

A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I . The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines.

Stereospecific Synthesis of Azetidine-cis-2,3-dicarboxylic Acid.

ChemInform ◽  
2003 ◽  
Vol 34 (23) ◽  
Author(s):  
Yasushi Arakawa ◽  
Tomoaki Murakami ◽  
Yukimi Arakawa ◽  
Shigeyuki Yoshifuji
Keyword(s):  
Dicarboxylic Acid ◽  
Stereospecific Synthesis

scholarly journals Stereospecific Synthesis of Azetidine-cis-2,3-dicarboxylic Acid

2003 ◽  
Vol 51 (1) ◽  
pp. 96-97 ◽  
Author(s):  
Yasushi Arakawa ◽  
Tomoaki Murakami ◽  
Yukimi Arakawa ◽  
Shigeyuki Yoshifuji
Keyword(s):  
Dicarboxylic Acid ◽  
Stereospecific Synthesis

scholarly journals Amino acid-derived bisphenolate palladium complexes as C-C coupling catalysts

2021 ◽  
Author(s):  
Eszter Fazekas ◽  
David T Jenkins ◽  
Andrew A Forbes ◽  
Brendan Gallagher ◽  
Georgina Rosair ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Palladium Complexes ◽  
Synthetic Method ◽  
Naturally Occurring ◽  
Chiral Amino Acids ◽  
Pendant Arms

A series of amine bisphenol (ABP) pro-ligands featuring amino acid ester pendant arms were prepared. Optimisation of the synthetic method allowed the facile incorporation of naturally occurring, chiral amino acids...

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