Correlation of isotope effects in substitution reactions with nucleophilicities. Secondary α-deuterium isotope effect in the iodide-131 exchange of methyl-d3 iodide
Keyword(s):
The secondary α-deuterium isotope effect in iodide-131 exchange of methyl-d3 iodide is kH/kD = 1.05 ± 0.01 in methanol and 1.10 ± 0.04 in water at 20°. A correlation of secondary α-deuterium and 13C effects, in bimolecular nucleophilic substitution reactions, with the difference of E values between nucleophile and leaving group is presented.
1979 ◽
Vol 57
(11)
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pp. 1354-1367
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1974 ◽
Vol 96
(10)
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pp. 3255-3261
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1993 ◽
pp. 1575-1582
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1982 ◽
Vol 23
(43)
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pp. 4423-4426
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