Influence of Lewis acids on the Diels–Alder reaction. III. Rearrangement of dimethyl N-carbomethoxy-7-azabicyclo[2.2.1]2,5-heptadiene-2,3-dicarboxylate adducts to dimethyl N-carbomethoxy-3-aminophthalates
Keyword(s):
Aluminum chloride accelerates the Diels–Alder reactions of 2- or 2,5-substituted N-carbomethoxypyrroles with dimethyl acetylenedicarboxylate, and also catalyzes rearrangement of the N-carbomethoxy-7-azanorbornadiene adducts to 6- and 4,6-substituted dimethyl N-carbomethoxy-3-aminophthalates. Aromatization of the corresponding adduct of N-carbomethoxypyrrole only occurs on prolonged treatment with BF3. The procedure promises to be a convenient route for the synthesis of polysubstituted anilines.
1973 ◽
Vol 51
(24)
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pp. 4125-4136
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1969 ◽
Vol 47
(13)
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pp. 2391-2394
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1978 ◽
Vol 43
(19)
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pp. 3727-3729
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1971 ◽
Vol 49
(19)
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pp. 3152-3157
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2006 ◽
Vol 84
(10)
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pp. 1487-1503
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