Configurationally dependent hydroxyl group effects on 13C nuclear magnetic resonance chemical shifts of olefinic carbons in cyclic six-membered allylic alcohols

1988 ◽  
Vol 66 (12) ◽  
pp. 3128-3131 ◽  
Author(s):  
Teodoro S. Kaufman
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Substituent Effects ◽  
Hydroxyl Group ◽  
Allylic Alcohols ◽  
Stereochemical Assignment ◽  
13C Nuclear Magnetic Resonance ◽  
Group Effects ◽  
Nuclear Magnetic

The differences in chemical shifts of olefinic carbons, Δδ(sp2), of pseudoequatorial and pseudoaxial six-membered allylic alcohols were correlated with the Δδ(sp2) values of their parent olefins. The results obtained reflect configurationally dependent substituent effects, the magnitude of which could be used for the stereochemical assignment of the hydroxyl group in these compounds.

Configurational assignment of epimeric secondary six-membered allylic alcohols by 13C nuclear magnetic resonance spectroscopy. A new approach

1986 ◽  
Vol 64 (12) ◽  
pp. 2331-2333 ◽  
Author(s):  
Teodoro S. Kaufman ◽  
Mirta P. Mischne ◽  
Manuel Gonzalez-Sierra ◽  
Edmundo A. Ruveda
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Hydroxyl Group ◽  
Allylic Alcohols ◽  
Resonance Spectroscopy ◽  
New Approach ◽  
Configurational Assignment ◽  
13C Nuclear Magnetic Resonance ◽  
Nuclear Magnetic

On the basis of the effects of the hydroxyl group on the 13C nuclear magnetic resonance chemical shifts of the olefinic carbons, a new parameter was defined and a new rule was proposed for the assignment of the stereochemistry of secondary six-membered cyclic allylic alcohols.

Nuclear Magnetic Resonance Chemical Shifts of some Monosubstituted Isothiazoles

1975 ◽  
Vol 53 (4) ◽  
pp. 596-603 ◽  
Author(s):  
Roderick E. Wasylishen ◽  
Thomas R. Clem ◽  
Edwin D. Becker
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Substituent Effects ◽  
Charge Densities ◽  
Monosubstituted Benzenes ◽  
Proton Chemical Shifts ◽  
Nuclear Magnetic

Carbon-13 and proton chemical shifts have been measured for several monosubstituted isothiazoles. Substituent effects upon these chemical shifts are compared with those observed for monosubstituted benzenes, pyridines, and thiophenes. In general the observed substituent effects in the isothiazoles and thiophenes closely parallel one another. Correlations between the observed carbon-13 Chemical shifts and CNDO/2 calculated charge densities are examined.

Semiempirical calculation of 13C nuclear magnetic resonance chemical shifts of acyclic hydrocarbons. Application to the stereochemical analysis of steroidal side chains

1988 ◽  
Vol 66 (1) ◽  
pp. 71-75 ◽  
Author(s):  
Manuel Gonzalez-Sierra ◽  
Daniel A. Bustos ◽  
Edmundo A. Ruveda ◽  
Alejandro C. Olivieri ◽  
Mariano Grasselli
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Side Chains ◽  
Stereochemical Analysis ◽  
Microcomputer Program ◽  
Semiempirical Approach ◽  
13C Nuclear Magnetic Resonance ◽  
Acyclic Hydrocarbons ◽  
Nuclear Magnetic

A semiempirical approach for predicting 13C nuclear magnetic resonance chemical shifts of acyclic hydrocarbons has been adapted to a microcomputer program. A series of methyl and dimethyl substituted cholesterols has been studied using this program, and the predicted shifts are in agreement with literature reports. Preferred conformations of the steroidal side chains have been also predicted and agree with previous studies. A simple rule for analyzing the trends in the chemical shift of the carbon C-20, which is sensitive to changes in the configuration at C-22, is also given, not only for hydrocarbon side chains but also for hydroxy substituted compounds.

A carbon-13 CP/MAS nuclear magnetic resonance study of several 1,4-disubstituted benzenes in the solid state

1989 ◽  
Vol 67 (3) ◽  
pp. 525-534 ◽  
Author(s):  
Glenn H. Penner ◽  
Roderick E. Wasylishen
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Substituent Effects ◽  
Nuclear Magnetic Resonance Study ◽  
Solution Studies ◽  
Temperature Solution ◽  
Cp Mas Nmr ◽  
Nuclear Magnetic

The carbon-13 chemical shifts of several 1,4-disubstituted benzenes in the solid state are reported. At least one of the substituents is unsymmetrical and in most cases this leads to different 13C chemical shifts of C-2 and C-6 and in some cases to different shifts for C-3 and C-5. The 13C chemical shifts observed in the solid state are compared with those measured in solution and, where possible, with those obtained in low temperature solution studies where internal rotation of the unsymmetrical substituent is slow on the 13C chemical shift time scale. Agreement between the chemical shifts observed in the solid state and solution is excellent. The potential application of CP/MAS nuclear magnetic resonance in deducing the conformation of benzene derivatives with two unsymmetrical substituents is discussed. Keywords: carbon-13 CP/MAS NMR, 13C NMR chemical shifts, substituent effects.

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