DISTORTION PRODUCT EMISSIONS: WHERE DO THEY COME FROM?

Purpose The effects of neurological diseases on the auditory system have been a notable issue for investigators because the auditory pathway is closely associated with neural systems. The purposes of this study are to evaluate the efferent auditory system function and hearing quality in Parkinson's disease (PD) and to compare the findings with age-matched individuals without PD to present a perspective on aging. Method The study included 35 individuals with PD (mean age of 48.50 ± 8.00 years) and 35 normal-hearing peers (mean age of 49 ± 10 years). The following tests were administered for all participants: the first section of the Speech, Spatial and Qualities of Hearing Scale; pure-tone audiometry, speech audiometry, tympanometry, and acoustic reflexes; and distortion product otoacoustic emissions (DPOAEs) and contralateral suppression of DPOAEs. SPSS Version 25 was used for statistical analyses, and values of p < .05 were considered statistically significant. Results There were no statistically significant differences in the pure-tone audiometry thresholds and DPOAE responses between the individuals with PD and their normal-hearing peers ( p = .732). However, statistically significant differences were found between the groups in suppression levels of DPOAEs and hearing quality ( p < .05). In addition, a statistically significant and positive correlation was found between the amount of suppression at some frequencies and the Speech, Spatial and Qualities of Hearing Scale scores. Conclusions This study indicates that medial olivocochlear efferent system function and the hearing quality of individuals with PD were affected adversely due to the results of PD pathophysiology on the hearing system. For optimal intervention and follow-up, tasks related to hearing quality in daily life can also be added to therapies for PD.

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Relationship Between Distortion Product Otoacoustic Emissions and Hearing Loss

Perspectives on Audiology ◽

10.1044/poa2.1.2 ◽

2006 ◽

Vol 2 (1) ◽

pp. 2-9

Author(s):

Tiffany A. Johnson ◽

Stephen T. Neely ◽

Michael P. Gorga

Keyword(s):

Hearing Loss ◽

Otoacoustic Emissions ◽

Distortion Product Otoacoustic Emissions ◽

Distortion Product

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Vocal Performance Teachers and Hearing Loss

Perspectives on Public Health Issues Related to Hearing and Balance ◽

10.1044/phi16.1.15 ◽

2015 ◽

Vol 16 (1) ◽

pp. 15-24

Author(s):

Vance Gunnell ◽

Jeff Larsen

Keyword(s):

Hearing Loss ◽

Otoacoustic Emissions ◽

Noise Exposure ◽

Vocal Performance ◽

Occupational Noise ◽

Hearing Conservation ◽

Occupational Noise Exposure ◽

Distortion Product ◽

Hearing Thresholds ◽

Performance Teachers

Hearing thresholds and distortion product otoacoustic emissions were measured for teachers of vocal performance who were gathered for a national conference. Results showed mean audiometric thresholds to be consistent with noise induced hearing loss, more than what would be expected with normal aging. Years of instruction and age were considered as factors in the hearing loss observed. It was concluded that hearing conservation should be initiated with this group to help raise awareness and protect them from hearing loss due to occupational noise exposure.

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Pengaruh sisplatin dosis tinggi terhadap penurunan fungsi sel rambut luar koklea

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v40i2.1 ◽

2013 ◽

Vol 40 (2) ◽

Author(s):

Asti Kristianti ◽

Teti Madiadipoera ◽

Bogi Soeseno

Keyword(s):

Hair Cells ◽

Malignant Neoplasm ◽

Otoacoustic Emission ◽

Outer Hair Cells ◽

High Dose ◽

Distortion Product Otoacoustic Emission ◽

Inclusion Criteria ◽

Cochlear Hair Cells ◽

Distortion Product ◽

Bilateral Sensorineural Hearing Loss

Background: Chemotherapy is worldwide used nowadays, and its toxicity still remain a problemespecially toxicity to the ear (ototoxicity). Cisplatin (cis-diamminedichloroplatinum) is one of themost commonly used chemotherapy and highly potent in treating epithelial malignancies. Ototoxicitycaused by cisplatin is irreversible, progressive, bilateral, sensorineural hearing loss especially on highfrequency (4-8 KHz) accompanied by tinnitus. Purpose: To observe the cochlear outer hair cells damagein malignancies patients treated with cisplatin. Methods: This study is an observational analytic studywith prospective design to determine the influence of high dose cisplatin on cochlear outer hair cellsfunction. The research was carried out at the ENT-HNS Department, Hasan Sadikin General HospitalBandung, from November 2007 until June 2008. Audiometry, tympanometry, and distortion productotoacoustic emission (DPOAE) examinations were conducted before chemotherapy and DPOAE, andtimpanometry was again measured three days after first and second cycles of cisplatin administration. McNemar test was performed to calculate the effects of high-dose cisplatin to the cochlear outer haircells function. To compare pre and post-cisplatin on alteration of cochlear hair cells function, Wilcoxontest was used. Results: In this study 60 ears from 30 subjects that meet the inclusion criteria, consistedof 25 man (83.3%) and 5 women (16.7%). The prevalence of damaged cochlear outer hair cells were63% at first cycle and 70% at second cycle of cisplatin administration. The decline of cochlear outerhair cells function was significant (p<0.001). Conclusion: High-dose cisplatin decreases cochlear outerhair cells function in patients with malignant neoplasm. Abstrak : Latar belakang: Kemoterapi sekarang rutin digunakan secara klinis di seluruh dunia. Sejalan denganhal tersebut toksisitas kemoterapi, khususnya terhadap telinga saat ini menjadi perhatian. Sisplatin(cis-diamminedichloroplatinum) adalah salah satu obat kemoterapi yang paling banyak digunakandan paling manjur untuk terapi keganasan epitelial. Efek ototoksik sisplatin yaitu terjadi gangguandengar sensorineural yang irreversible, progresif, bilateral pada frekuensi tinggi (4-8 kHz), dan disertaidengan tinitus. Tujuan: Untuk menilai penurunan fungsi sel rambut luar koklea pada penderita tumorganas sesudah pemberian sisplatin dosis tinggi dengan menggunakan DPOAE. Metode: Studi analitikobservasional dengan rancangan prospektif di Bagian IK. THT-KL RS. Hasan Sadikin Bandung mulaibulan November 2007 sampai dengan Juni 2008. Pada penelitian ini dilakukan pemeriksaan audiometrinada murni, timpanometri, dan distortion product otoacoustic emission (DPOAE) prakemoterapi, kemudianDPOAE dan timpanometri diulang tiga hari sesudah siklus pertama dan kedua kemoterapi sisplatin. Datayang diperoleh diuji dengan uji McNemar dan uji Wilcoxon. Hasil: Dari penelitian didapat 60 telingadari 30 subjek penelitian yang memenuhi kriteria inklusi yang terdiri dari 25 laki-laki (83,3%) dan 5perempuan (16,7%). Insidens penurunan fungsi sel rambut luar koklea sebesar 63% (38 kasus) sesudahsiklus pertama dan 70% (42 kasus) sesudah siklus kedua. Hubungan penurunan fungsi sel rambut luarkoklea memberikan nilai yang sangat bermakna sejak pemberian siklus pertama (p<0,001). Kesimpulan:Pemberian sisplatin dosis tinggi pada penderita tumor ganas menyebabkan penurunan fungsi sel rambutluar koklea.Kata kunci: kemoterapi, sisplatin dosis tinggi, sel rambut luar koklea.

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Therapeutic effect of combined antioxidant drugs (4-OHPBN plus NAC) on acute acoustic trauma in terms of distortion product otoacoustic emission

Audiology and Speech Research ◽

10.21848/audiol.2011.7.1.51 ◽

2011 ◽

Vol 7 (1) ◽

pp. 51-59

Author(s):

Chul-Hee Choi

Keyword(s):

Therapeutic Effect ◽

Otoacoustic Emission ◽

Acoustic Trauma ◽

Distortion Product Otoacoustic Emission ◽

Distortion Product ◽

Acute Acoustic Trauma

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The Effects of Round Window Membrane Injury and the Use of a Model Electrode Application on Hearing in Rats

Ear Nose & Throat Journal ◽

10.1177/0145561321990188 ◽

2021 ◽

pp. 014556132199018

Author(s):

Murat Koc ◽

Abdullah Dalgic ◽

Mehmet Ziya Ozuer

Keyword(s):

Hearing Loss ◽

Cochlear Implant ◽

Round Window ◽

Mechanical Trauma ◽

Round Window Membrane ◽

Albino Rats ◽

Topical Steroids ◽

Distortion Product ◽

Significant Difference ◽

Group 3

Objective: To investigate the effects of the mechanical trauma to the round window, a model electrode inserted into the scala tympani on the cochlear reserve, and the efficacy of topical steroids in preventing hearing loss. Materials and Methods: 21 male Wistar Albino rats were equally categorized into three groups. In all groups an initial mechanical injury to round window was created. Only subsequent dexamethasone injection was administrated into the cochlea in the subjects of group 2 while a multichannel cochlear implant guide inserted into the cochlea prior to dexamethasone administration for group 3. Distortion product otoacoustic emissions (DPOAEs) were obtained prior to and immediately after the surgical injury, eventually on postoperative seventh day (d 7). Mean signal/noise ratios (S/Ns) obtained at 2000, 3000, and 4000 Hz were calculated. Data sets were compared with non-parametric statistical tests. Results: The early intraoperative mean S/Ns were significantly less than preoperative measurements for group 1 and 2; however, preoperative and postoperative d 7 average S/Ns did not differ. There was statistically significant difference between preoperative, intraoperative and postoperative d 7 average S/Ns for group 3. Conclusion: We observed that hearing was restored approximately to the preoperative levels following early postoperative repair. However, an electrode insertion into the cochlea via round window subsequent to mechanical trauma seems to cause a progressive hearing loss. Therefore, a special care must be taken to avoid the injury to the round window membrane in the course of the placement of a cochlear implant electrode and surgery for the chronic otitis media.

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