Magnetic Field Effects in Radical Pairs and Exciplexes Resulting From Spin-Dynamics Caused by Hyperfine Interaction, g-factor Variations as Well as Ferromagnetic Fringe Fields

Author(s):  
Markus Wohlgenannt
2021 ◽  
Author(s):  
Hadi ZADEH-HAGHIGHI ◽  
Christoph Simon

The exact mechanism behind general anesthesia remains an open question in neuroscience. It has been proposed that anesthetics selectively prevent consciousness and memory via acting on microtubules (MTs). It is known that the magnetic field modulates MT organization. A recent study shows that a radical pair model can explain the isotope effect in xenon-induced anesthesia and predicts magnetic field effects on anesthetic potency. Further, reactive oxygen species are also implicated in MT stability and anesthesia. Based on a simple radical pair mechanism model and a simple mathematical model of MT organization, we show that magnetic fields can modulate spin dynamics of naturally occurring radical pairs in MT. We show that the spin dynamics influence a rate in the reaction cycle, which translates into a change in the MT density. We can reproduce magnetic field effects on the MT concentration that have been observed. Our model also predicts additional effects at slightly higher fields. Our model further predicts that the effect of zinc on the MT density exhibits isotopic dependence. The findings of this work make a connection between microtubule-based and radical pair-based quantum theories of consciousness.


2001 ◽  
Vol 74 (5) ◽  
pp. 773-783 ◽  
Author(s):  
Hisaharu Hayashi ◽  
Yoshio Sakaguchi ◽  
Masanobu Wakasa

2009 ◽  
Vol 37 (2) ◽  
pp. 358-362 ◽  
Author(s):  
Jonathan R. Woodward ◽  
Timothy J. Foster ◽  
Alex R. Jones ◽  
Adrian T. Salaoru ◽  
Nigel S. Scrutton

The effect of magnetic fields on chemical reactions through the RP (radical pair) mechanism is well established, but there are few examples, in the literature, of biological reactions that proceed through RP intermediates and show magnetic field-sensitivity. The present and future relevance of magnetic field effects in biological reactions is discussed.


2015 ◽  
Vol 17 (15) ◽  
pp. 9737-9747 ◽  
Author(s):  
Tomoaki Yago ◽  
Masanobu Wakasa

A practical method to calculate time evolutions of magnetic field effects (MFEs) on photochemical reactions involving radical pairs is developed on the basis of the theory of the chemically induced dynamic spin polarization proposed by Pedersen and Freed.


1998 ◽  
Vol 102 (2) ◽  
pp. 464-472 ◽  
Author(s):  
B. van Dijk ◽  
J. K. H. Carpenter ◽  
A. J. Hoff ◽  
P. J. Hore

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