ACTIVATED PROTEIN C RESISTANCE DUE TO A COMMON FACTOR V GENE MUTATION IS A MAJOR RISK FACTOR FOR VENOUS THROMBOSIS

1997 ◽  
Vol 48 (1) ◽  
pp. 45-58 ◽  
Author(s):  
B. Zöller, MD ◽  
A. Hillarp, PhD ◽  
E. Berntorp, MD ◽  
B. Dahlbäck, MD
Keyword(s):  
Risk Factor ◽  
Venous Thrombosis ◽  
Gene Mutation ◽  
Protein C ◽  
Common Factor ◽  
Activated Protein C ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Gene ◽  
V Gene

scholarly journals Activated Protein C Resistance and Factor V Leiden in Mexico

2007 ◽  
Vol 14 (4) ◽  
pp. 428-437 ◽  
Author(s):  
Abraham Majluf-Cruz ◽  
Manuel Moreno-Hernández ◽  
Adriana Ruiz-de-Chávez-Ochoa ◽  
Rosario Monroy-García ◽  
Karim Majluf-Cruz ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Leiden Mutation ◽  
Common Cause ◽  
Factor V Gene ◽  
V Gene ◽  
Low Prevalence

A common cause of hereditary thrombophilia is activated protein C resistance (APCR), and most cases result from factor V Leiden mutation. An APCR phenotype without association with factor V Leiden has been described. This transversal, observational, nonrandomized study evaluated these 2 phenomena in healthy indigenous and mestizo Mexican subjects (n = 4345), including 600 Mexican natives. No indigenous subjects had APCR, but 82 mestizo subjects did. After retesting, 50 subjects had a negative test. The remaining 32 subjects had factor V Leiden, giving a 0.85% prevalence of factor V Leiden in the mestizo Mexican population. Only 31% of APCR carriers had factor V Leiden. These results show a very low prevalence of APCR and factor V Leiden in Mexico. Except for factor V Leiden, there are no other mutations in the factor V gene responsible for the APCR phenotype. Acquired APCR is nearly twice as prevalent as the inherited variant.

High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis

1994 ◽  
Vol 88 (1) ◽  
pp. 219-222 ◽  
Author(s):  
Nicholas J. Beauchamp ◽  
Martina E. Daly ◽  
K. K. Hampton ◽  
Peter C. Cooper ◽  
F. Eric Preston ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
High Prevalence ◽  
Factor V Gene ◽  
V Gene

Resistance to activated protein C due to a factor V gene mutation

1996 ◽  
Vol 6 (2) ◽  
pp. 45-53 ◽  
Author(s):  
Bengt Zöller ◽  
Johan Holm ◽  
Björn Dahlbäck
Keyword(s):  
Gene Mutation ◽  
Protein C ◽  
Activated Protein C ◽  
Factor V ◽  
Factor V Gene ◽  
V Gene
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