Coagulation factor V gene mutation associated with activated protein C resistance leading to recurrent thrombosis, leg ulcers, and lymphedema: successful treatment with intermittent compression

1996 ◽  
Vol 35 (2) ◽  
pp. 306-309 ◽  
Author(s):  
Dominik Peus ◽  
Sherko v Schmiedeberg ◽  
Andreas Pier ◽  
Rüdiger E Scharf ◽  
Artur Wehmeier ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Coagulation Factor ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Recurrent Thrombosis ◽  
Intermittent Compression ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

Coagulation Factor V Leiden Mutation Was Detected in the Patients with Activated Protein C Resistance in Thailand

1998 ◽  
Vol 80 (08) ◽  
pp. 344-345 ◽  
Author(s):  
Pasra Arnutti ◽  
Motofumi Hiyoshi ◽  
Wichai Prayoonwiwat ◽  
Oytip Nathalang ◽  
Chamaiporn Suwanasophon ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Coagulation Factor ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Leiden Mutation ◽  
Coagulation Factor V

scholarly journals Activated Protein C Resistance and Factor V Leiden in Mexico

2007 ◽  
Vol 14 (4) ◽  
pp. 428-437 ◽  
Author(s):  
Abraham Majluf-Cruz ◽  
Manuel Moreno-Hernández ◽  
Adriana Ruiz-de-Chávez-Ochoa ◽  
Rosario Monroy-García ◽  
Karim Majluf-Cruz ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Leiden Mutation ◽  
Common Cause ◽  
Factor V Gene ◽  
V Gene ◽  
Low Prevalence

A common cause of hereditary thrombophilia is activated protein C resistance (APCR), and most cases result from factor V Leiden mutation. An APCR phenotype without association with factor V Leiden has been described. This transversal, observational, nonrandomized study evaluated these 2 phenomena in healthy indigenous and mestizo Mexican subjects (n = 4345), including 600 Mexican natives. No indigenous subjects had APCR, but 82 mestizo subjects did. After retesting, 50 subjects had a negative test. The remaining 32 subjects had factor V Leiden, giving a 0.85% prevalence of factor V Leiden in the mestizo Mexican population. Only 31% of APCR carriers had factor V Leiden. These results show a very low prevalence of APCR and factor V Leiden in Mexico. Except for factor V Leiden, there are no other mutations in the factor V gene responsible for the APCR phenotype. Acquired APCR is nearly twice as prevalent as the inherited variant.

High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis

1994 ◽  
Vol 88 (1) ◽  
pp. 219-222 ◽  
Author(s):  
Nicholas J. Beauchamp ◽  
Martina E. Daly ◽  
K. K. Hampton ◽  
Peter C. Cooper ◽  
F. Eric Preston ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
High Prevalence ◽  
Factor V Gene ◽  
V Gene

A Novel Mutation (G2172→C) in the Factor V Gene in a Chinese Family with Hereditary Activated Protein C Resistance

2010 ◽  
Vol 125 (6) ◽  
pp. 545-548 ◽  
Author(s):  
Huacong Cai ◽  
Baolai Hua ◽  
Liankai Fan ◽  
Qian Wang ◽  
Shujie Wang ◽  
...  
Keyword(s):  
Protein C ◽  
Novel Mutation ◽  
Activated Protein C ◽  
Chinese Family ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Gene ◽  
V Gene
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