Clinical and laboratory testing of oral anticoagulation therapy vitamin k antagonists at the emergency department of Hanoi Heart Hospital

Background: The most commonly used oral anticoagulant is acenocoumarol with the brand name is Sintrom and recently, warfarin with the brand name is Coumadin has begun to be used. Anticoagulation with vitamin K antagonists faces two main obstacles: the narrow therapeutic range and the effectiveness of the drug varies by many factors. Objective: " Current status of coagulation disorders in the treatment of anticoagulants with vitamin K antagonists. Understanding some factors affecting the goal of anticoagulant treatment". Method: Cross-sectional, retrospective, descriptive analysis of drug use and influencing factors of patients diagnosed with coagulopathy admitted to the emergency department at Hanoi Heart Hospital from April 2020 to August 2021. Results: There were 675 patients admitted to the hospital with blood clotting disorders. The average age is 60,17±10,13, the youngest is 30, the oldest is 90; 63 patients, accounting for 9.42%, need to be hospitalized for inpatient treatment; There are 108 patients, accounting for 16%, with bleeding and 18 patients, accounting for 2.7%, with thromboembolism or valve obstruction. Conclusion: Coagulation disorders during treatment with vitamin K antagonist anticoagulants is a common condition in the emergency department. However, the complication rate is not high. There are many factors that affect the patient's treatment goals and the drug use is a fairly common factor.

Knowledge, Attitude and Practice of Skin Whitening Products, Among Sudanese Undergraduate Females, 2021.

Objectives: The knowledge, attitude and practice of skin-whitening products among female undergraduates in the medical campus, University of Khartoum.Methods: A cross-sectional study was conducted at the medical campus of University of Khartoum. All consenting female undergraduates were included in the study population. 417 women were chosen through proportional stratified random sampling, and were asked to complete a questionnaire.365 completed the questionnaire with a response rate of 87%. Result: 365 women completed the questionnaire, of whom 52% had average knowledge, 32% had poor knowledge and 16% had excellent knowledge,.32% had a positive attitude, and 38% reported using skin-whitening products.Knowledge, attitude and practice were associated with several factors.Conclusion : Although The overall knowledge about skin-whitening products is average. The knowledge about skin-whitening agents is rather poor. The majority of Sudanese University students have a negative attitude towards skin-whitening, but still the use of skin-whiteners is common amongst them .. Women who feel pressured by society to whiten their skin, are more likely to use skin-whiteners, as well as those who have a family history of skin-whitening. Media and social media play an important role in this matter, being the most important source of information and the most common factor pressuring women to lighten their skin as well. We recommend media and social to be used to promote the acceptance of dark skin and raise awareness about the safe practice of skin whitening. We also recommend that the Ministry of Health and Standards and Metrology Authority mandate the labeling of all products sold in Sudan detailing ingredients and concentrations of ingredients.

Unilateral Eagle’s Syndrome

Eagle’s syndrome represent as a neck, cervicofacial pain, dysphagia, facial pain, globus sensation, tinnitus, otalgia and headache, it may be unilateral or bilateral. About 4% of adult population accounted elongated styloid process, which are the principal factor of Eagle’s syndrome and followed by 0.16% of patients are symptomatic. Stylohyoid ligament calcification is the second most common factor. The diagnosis must be made through a detailed history, clinical examination, and various imaging modalities. A 36 years old female patient presented with persistent pain in the throat. An elongated styloid process was diagnosed and was removed by transoral approach following the patient was relieved from her symptoms. J Bangladesh Coll Phys Surg 2022; 40: 72-74

Evaluation of development of Apple Inc. stock price time series

The paper deals with the the development of a specific company’s stock price time series. The aim of the paper is to use the time series method for a detailed analysis and evaluation of the development of Apple Inc. stock prices. Daily data from 2000 to 2020, daily data from the period of the economic crisis between 2007 and 2009 and daily data from the Covid-19 pandemic period from March 2020 to the end of the same year are used. The data, from the period of 2000 - 2020 show a gradual increase in Apple’s stock prices. The most common factor leading to the increase in stock prices is the launch of a new product or service on the global market. On the contrary, the reason for the decline in stock prices is customer dissatisfaction, the excess of demand over supply, or the political situation. The analysis of time series for the period of the economic crisis points to the fact that thanks to the development, innovation and constant introduction of new products into the market, the company was not significantly affected by the crisis and neither were stock prices. Naturally, there were some fluctuations in prices, but at the end of 2009, the company even reached the highest stock prices in its history to date. The analysis of time series during the global pandemic of Covid-19 shows a steady rise in stock prices. Currently, the company sells more and more products and introduces new services that help us work, study or entertain ourselves in these difficult times, in the safety of our homes.

Later Chronotype Correlates With Severe Depression in Indonesian College Students

Background and Objective The correlation between late chronotype and depression has been well documented, but reports from the equatorial area, where the sun shines throughout the year with less seasonal variation, are limited. In the present research study, we sought to 1) examine the relationship between the chronotype and mental health symptoms in an Indonesian student population and 2) explore the characteristics of those who lie at the extreme chronotype and psychometry.Methods This is a cross-sectional questionnaire-based study including undergraduate students in an Indonesian university (n = 493). We used the Munich Chronotype Questionnaires and the Depression, Anxiety, and Stress Scale to assess the chronotype and mental symptoms, respectively. Following this, a follow-up with an in-depth interview on the selected population at the extreme end of the chronotype was performed as an exploratory approach to identify their common characteristics.Results Among the tested parameters, the depression score was significantly associated with chronotype (p = 0.003), replicating previous findings from other areas with higher latitudes. The correlation persisted when males and females were analyzed separately (p = 0.008 and 0.037, respectively). A follow-up qualitative analysis revealed a potential subclinical, unrealized depression among the subjects; our findings revealed the use of smartphones during or before bedtime as a common factor among those with later chronotypes.Conclusions There is a correlation between depression score and chronotype among Indonesian college students, where subjects with later chronotype are more likely to have a higher depression score.

Assessment of the Efficiency of HP-Guar and hyaluronic Acid Tear Supplements to Control Tear Film Evaporation Rate in Dry Eye Subjects

Background: The most common factor that could lead to dryness is the accelerated tear evaporation rate. Controlling the tear evaporation rate is increasingly used as a method to control dry eye complications. The present study explores the effects of different tear supplements formulations on tear film evaporation rate. Objective: This study aimed to evaluate the short-term effects of Systane ULTRA and Artelac Advanced eye drops on the tear film evaporation rate. Methods: Fifteen male dry eye subjects were enrolled in the current study. Tear film parameters were observed at several time points post installation (10, 20, 30, and 60 min). The tear film parameters observed in the current study were tear evaporation rate, noninvasive breakup time (NITBUT) and tear meniscus height (TMH). Two visits were required to conduct this study. One visit was conducted to assess the physiological tear film parameters with the use of Systane® ULTRA eye drop. The other visit was conducted to assess tear film parameters with the use of Artelac Advanced eye drop. Results: The mean tear evaporation rate at baseline was 52.58 ± 23.24 g/m2 h. A box plot of tear evaporation showed a reduction in tear film evaporation rate after instillation of Systane eye drop. A drop in tear film evaporation rate of 14% was observed at 20 and 60 min time point after instillation of Systane ULTRA eye drop. A significant increase in NITBUT was found after instillation of Systane ULTRA (P = 0.01) and Artelac Advanced (P = 0.02). Conclusion: The current study indicates a significant improvement in the tear film parameters using both HP-Guar and hyaluronic acid formulations. However, it was apparent that the use of HP-Guar was superior to hyaluronic acid in controlling the tear evaporation rate in dry eye subjects.

Management of Monetary Policy in the Framework of Decision Making on Setting Interest Rates for Sustainable Social System: Example of the Russian Federation

This work was based on empirical studies of the credit register and loans issued, which have been compiled by all Russian banks since 2017, for the analysis of bank interest rates by a common factor and subject to the control of the characteristics of the loan. These dates identified bank-specific components in the management information system; also, the same data were used to measure the fragmentation of the accounting lending market in Russia. This paper illustrates the credit market in Russia during the COVID-19 pandemic by analyzing the management of loan rates with existing differences due to the heterogeneity of banks and borrowers in order to achieve a sustainable management system. The results show that the heterogeneity of banks’ decision-making when setting interest rates is high and increased at an early stage of the pandemic. Additionally, the results demonstrate that the banks tightened interest-free lending conditions during the pandemic for sustainable management goals.

INNOVATION FAILURE IN SMEs: A NARRATIVE APPROACH TO UNDERSTAND FAILED INNOVATIONS AND FAILED INNOVATORS

While innovation is an attractive path, it is also a rocky path made up of numerous challenges, even failures. This study provides new knowledge for understanding innovation failure. It seeks answers to the question: What are the perceived factors of innovation failure in SMEs? Every individual who has experienced an innovation failure has a story to tell. Therefore, the research question of this study is answered based on these stories. The main data are collected through narratives produced by individuals who have been involved in the development of completely failed innovation initiatives. In addition, four expert interviews are conducted. The results demonstrate that the most common factor for innovation failure is the occurrence of several incidents during the innovation process that slowly contribute to complete failure. In addition, the results reveal three SME-typical narratives of failed innovations as narrators the Passionate Innovator, the Solo Innovator, and the Developer Innovator.