Double Arterial Phase Multi–Detector Row Helical CT for Detection of Hypervascular Hepatocellular Carcinoma [letter]

Radiology ◽  
2003 ◽  
Vol 229 (3) ◽  
pp. 931-932 ◽  
Author(s):  
Takamichi Murakami ◽  
Tonsok Kim ◽  
Masatoshi Hori ◽  
Michael P. Federle
Keyword(s):  
Hepatocellular Carcinoma ◽  
Helical Ct ◽  
Arterial Phase

Hypervascular Hepatocellular Carcinoma: Detection with Double Arterial Phase Multi-Detector Row Helical CT

Radiology ◽  
2001 ◽  
Vol 218 (3) ◽  
pp. 763-767 ◽  
Author(s):  
Takamichi Murakami ◽  
Tonsok Kim ◽  
Manabu Takamura ◽  
Masatoshi Hori ◽  
Satoru Takahashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Helical Ct ◽  
Arterial Phase

Sensitivity in detection of hypervascular hepatocellular carcinoma by helical ct with intra-arterial injection of contrast medium, and by helical CT and MR imaging with intravenous injection of contrast medium

1998 ◽  
Vol 39 (2) ◽  
pp. 144-151 ◽  
Author(s):  
M. Hori ◽  
T. Murakami ◽  
H. Oi ◽  
T. Kim ◽  
S. Takahashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Contrast Medium ◽  
Spin Echo ◽  
Equilibrium Phase ◽  
Helical Ct ◽  
Arterial Phase ◽  
Contrast Enhanced ◽  
Significant Difference ◽  
Dynamic Mr

Purpose: to determine the effectiveness of i.a. contrast-enhanced helical CT and of i.v. contrast-enhanced helical CT and MR imaging, in detecting hyper-vascular hepatocellular carcinoma (HCC) Material and Methods: Fifty patients with 125 hypervascular HCC nodules underwent helical CT both during arterial portography (CTAP) and during hepatic arteriography (CTHA). Helical CT and MR imaging of the entire liver with i.v. administration of contrast medium were also performed. Helical CT images were obtained at 30–33 s (arterial-phase CT) and at 5 min (equilibrium-phase CT) after the initiation of an i.v. bolus injection of contrast medium. After T1- and T2-weighted spin-echo MR imaging, gradient-echo images during breath-holding were obtained prior to and 20 s, 1 min, and 2 min after the bolus administration of 0.1 mmol/kg of gadopentetate dimeglumine (dynamic MR). the sensitivity and positive predictive value of the various techniques were evaluated and compared Results: in terms of sensitivity for hypervascular HCC nodules of less than 1 cm in diameter, CTAP (90%) and CTHA (88%) were significantly superior to dynamic MR imaging (44%), arterial-phase CT (39%), spin-echo MR imaging (20%), and equilibrium-phase CT (7%) ( p>0.001). However, there was no significant difference in the techniques with regard to the detection of lesions equal to or more than 2 cm in diameter Conclusion: for detecting small hypervascular HCCs, helical CT with i.a. contrast enhancement is superior to helical CT and MR imaging with i.v. enhancement

Detection of Hepatocellular Carcinoma: Comparison of Dynamic MR Imaging with Dynamic Double Arterial Phase Helical CT

2003 ◽  
Vol 180 (2) ◽  
pp. 455-460 ◽  
Author(s):  
Yumi Noguchi ◽  
Takamichi Murakami ◽  
Tonsok Kim ◽  
Masatoshi Hori ◽  
Keigo Osuga ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Helical Ct ◽  
Arterial Phase ◽  
Dynamic Mr Imaging ◽  
Dynamic Mr

Spiral CT of Hepatocellular Carcinoma: Correlation of CT Scans during the Arterial Phase with Angiography

1996 ◽  
Vol 34 (4) ◽  
pp. 507
Author(s):  
Han Kyung Lee ◽  
Byung Ihn Choi ◽  
Joon Koo Han ◽  
Dae Young Yoon ◽  
Jae Min Cho ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Spiral Ct ◽  
Ct Scans ◽  
Arterial Phase

Differentiation between hepatocellular carcinoma and intrahepatic cholangiocarcinoma using contrast-enhanced ultrasound: A systematic review and meta-analysis

2021 ◽  
pp. 1-17
Author(s):  
Yanling Chen ◽  
Wenping Wang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Accuracy ◽  
Publication Bias ◽  
Likelihood Ratio ◽  
Intrahepatic Cholangiocarcinoma ◽  
Cochrane Library ◽  
Arterial Phase ◽  
Contrast Enhanced Ultrasound ◽  
Diagnostic Ability ◽  
Contrast Enhanced

AIM: To explore the diagnostic ability of contrast-enhanced ultrasound (CEUS) in distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC). MATERIALS AND METHODS: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for studies reporting the diagnostic accuracy of CEUS in differentiating ICC from HCC. The diagnostic ability of CEUS was assessed based on the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the curve (AUC) with 95% confidence intervals (CIs). The methodologic quality was assessed by the QUADAS-2 tool. Subgroup analyses, meta-regression and investigation of publication bias were performed to identify the source of heterogeneity. RESULTS: A total of eight studies were included, consisting of 1,116 patients with HCC and 529 with ICC. The general diagnostic performance of CEUS in distinguishing ICC and HCC were as follows: pooled sensitivity, 0.92 (95% CI: 0.84–0.96); pooled specificity, 0.87 (95% CI: 0.79–0.92); pooled PLR, 7.1 (95% CI: 4.1–12.0); pooled NLR, 0.09 (95% CI: 0.05–0.19); pooled DOR, 76 (95% CI: 26–220) and AUC, 0.95(95% CI: 0.93–0.97). Different liver background may be a potential factor that influenced the diagnostic accuracy of CEUS according to the subgroup analysis, with the pooled DOR of 89.67 in the mixed liver background group and 46.87 in the cirrhosis group, respectively. Six informative CEUS features that may help differentiate HCC from ICC were extracted. The three CEUS features favoring HCC were arterial phase hyperenhancement(APHE), mild washout and late washout (>60s); the three CEUS favoring ICC were arterial rim enhancement, marked washout and early washout(<60s). No potential publication bias was observed. CONCLUSION: CEUS showed great diagnostic ability in differentiating ICC from HCC, which may be promising for noninvasive evaluation of these diseases.

scholarly journals Hepatic Epithelioid Hemangioendothelioma Presenting Synchronously with Hepatocellular Carcinoma

2021 ◽  
pp. 344-351
Author(s):  
Hiroki Kanno ◽  
Toshihiro Sato ◽  
Ryuta Midorikawa ◽  
Satoki Kojima ◽  
Shogo Fukutomi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carbohydrate Antigen ◽  
Epithelioid Hemangioendothelioma ◽  
Arterial Phase ◽  
Rapid Progression ◽  
Imaging Findings ◽  
Liver Segment ◽  
Contrast Enhanced ◽  
Well Differentiated ◽  
Enhanced Computed Tomography

Hepatic epithelioid hemangioendothelioma (EHE) is a rare malignant tumor with unknown pathogenesis. Herein, we report a case of a hepatic EHE presenting synchronously with a hepatocellular carcinoma (HCC). To the best of our knowledge, this is the second case report of synchronous hepatic EHE and HCC. An 84-year-old man presented with back pain. During examination, a tumor in liver segment 3 was coincidentally detected. Tumor marker (carbohydrate antigen 19-9, alpha-fetoprotein, and protein induced by vitamin K absence or antagonist-II) levels were elevated. Contrast-enhanced computed tomography revealed perinodular enhancement in the arterial and portal phases. Another tumor was detected in liver segment 2, which was homogeneously enhanced in the arterial phase, followed by washout in the portal and late phases. Based on these imaging findings, we diagnosed the tumor in segment 3 as a solitary cholangiocellular carcinoma and the tumor in segment 2 as a solitary HCC. Lateral sectionectomy of the liver was performed. Microscopically, spindle-shaped and epithelioid cells were present in the tumor in segment 3. On immunohistochemistry, the tumor cells were positive for CD31 and CD34, focally positive for D2-40, and negative for AE1/AE3. Therefore, the tumor in segment 3 was ultimately diagnosed as an EHE and the tumor in segment 2 as a well-differentiated HCC. Preoperative diagnosis of EHE is difficult owing to the lack of specific findings. Intratumoral calcification, halo sign, and lollipop sign are occasionally found in EHE and are useful imaging findings for diagnosis. Clinical behavior is unpredictable, ranging from indolent growth to rapid progression. Clinical or pathological predictors of the course of EHE are urgently required.

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