Focal and diffuse liver disease studied by quantitative microstructural sonography.

Radiology ◽  
1985 ◽  
Vol 155 (2) ◽  
pp. 457-462 ◽  
Author(s):  
D L King ◽  
F L Lizzi ◽  
E J Feleppa ◽  
P M Wai ◽  
M M Yaremko ◽  
...  
1987 ◽  
Vol 28 (3) ◽  
pp. 281-284 ◽  
Author(s):  
Lillemor Forsberg ◽  
C. H. Florén ◽  
E. Hederström ◽  
H. Prytz

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Alexey Borsukov ◽  
Tatiana Morozova ◽  
Alexey Kovalev

The purpose of the research was to estimate the clinical-diagnostic and predictive value of non-invasive ultrasonic elastography in dynamic monitoring in patients with diffuse liver disease. A number of 114 patients with diffuse liver disease were examined, specifically 68 (59.6%) men and 46 (40.4%) women. The patients were divided into three groups: 40 patients with steatosis; 38 with hepatitis; 36 with cirrhosis. The research included clinical and bio-chemical analysis, ultrasound examination of liver and spleen with doppler v. portae and v. lienalis, elastography of liver and spleen. The study found a high correlation of elastography data as regards the liver and spleen in patients with alcoholic cirrhosis (r=0.96), average correlation (r=0.69) in patients with steatosis and hepatitis of alcoholic etiology. On the basis of the statistical program receiver operating characteristic (ROC)-analysis it was ascertained that the spleen is in perfect condition (AUC 0.9-1.0), and the liver is in a very good condition (0.8-0.9). The research revealed therapeutically significant factor ΔF/ΔL for dynamic monitoring: the ΔF/ΔL 1 can predict a more favorable course of the disease. Noninvasive ultrasound elastography helps to forecast the process of the disease and correct the therapeutic approach. The research contributes to the search for additional and reliable techniques of identifying the stage of disease of patients with hepatic fibrosis, the dynamics of the disease as well as forecasting further complications.


2020 ◽  
Vol 45 (11) ◽  
pp. 3507-3522 ◽  
Author(s):  
Helena B. Thomaides-Brears ◽  
Rita Lepe ◽  
Rajarshi Banerjee ◽  
Carlos Duncker

Abstract Accurate diagnosis, monitoring and treatment decisions in patients with chronic liver disease currently rely on biopsy as the diagnostic gold standard, and this has constrained early detection and management of diseases that are both varied and can be concurrent. Recent developments in multiparametric magnetic resonance imaging (mpMRI) suggest real potential to bridge the diagnostic gap between non-specific blood-based biomarkers and invasive and variable histological diagnosis. This has implications for the clinical care and treatment pathway in a number of chronic liver diseases, such as haemochromatosis, steatohepatitis and autoimmune or viral hepatitis. Here we review the relevant MRI techniques in clinical use and their limitations and describe recent potential applications in various liver diseases. We exemplify case studies that highlight how these techniques can improve clinical practice. These techniques could allow clinicians to increase their arsenals available to utilise on patients and direct appropriate treatments.


2020 ◽  
Vol 45 (11) ◽  
pp. 3425-3443
Author(s):  
Hilton Leao Filho ◽  
Camila Vilela de Oliveira ◽  
Natally Horvat

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