Low Doses of Recombinant Human Tissue-Type Plasminogen Activator for Local Thrombolysis in Peripheral Arteries

Radiology ◽  
1988 ◽  
Vol 168 (3) ◽  
pp. 877-877 ◽  
Author(s):  
Renate Koppensteiner ◽  
Erich Minar ◽  
Ramazanali Ahmadi ◽  
Michael Jung ◽  
Herbert Ehringer
Keyword(s):  
Plasminogen Activator ◽  
Human Tissue ◽  
Tissue Type ◽  
Low Doses ◽  
Peripheral Arteries ◽  
Tissue Type Plasminogen Activator ◽  
Local Thrombolysis ◽  
Type Plasminogen Activator

D-Dimer in Local Thrombolytic Therapy with Low Doses of Recombinant Human Tissue-Type Plasminogen Activator (rt-PA) in Patients with Peripheral Arterial Occlusive Disease

1990 ◽  
Vol 64 (02) ◽  
pp. 192-195 ◽  
Author(s):  
Renate Koppensteiner ◽  
Wolfgang Speiser ◽  
Erich Minar ◽  
Ramazan Ahmadi ◽  
Herbert Ehringer
Keyword(s):  
Thrombolytic Therapy ◽  
Plasminogen Activator ◽  
Human Tissue ◽  
Tissue Type ◽  
Low Doses ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Local Thrombolytic Therapy ◽  
Peripheral Arterial ◽  
D Dimer

SummaryThe generation of D-dimer was studied in the course of local thrombolytic therapy of peripheral arterial occlusions with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in 7 patients. Intermittent local application of rt-PA resulted in a marked increase in D-dimer exceeding values usually seen after intravenous application of manifold higher doses used in myocardial infarction. The increase in D-dimer was related to the estimated thrombus size (length of the occlusion) and the total dose of rt-PA applied. During local rt-PA infusion 6 of 7 patients maintained plasminogen activator inhibitor capacity (PAI-cap) between 34% and 79% of their corresponding pre-treatment levels; detectable levels of PAI-cap in circulating blood during the procedure did not interfere with the success of therapy.

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