Complete Free-breathing Adenosine Stress Cardiac MRI Using Compressed                     Sensing and Motion Correction: Comparison of Functional Parameters, Perfusion,                     and Late Enhancement with the Standard Breath-holding                     Examination

AbstractCardiac MRI in rhesus macaques, a species of major relevance for preclinical studies on biological therapies, requires artificial ventilation to realize breath holding. To overcome this limitation of standard cine MRI, the feasibility of Real-Time (RT) cardiac MRI has been tested in a cohort of ten adult rhesus macaques using a clinical MR-system. In spite of lower tissue contrast and sharpness of RT-MRI, cardiac functions were similarly well assessed by RT-MRI compared to cine MRI (similar intra-subject repeatability). However, systematic underestimation of the end-diastolic volume (31 ± 9%), end-systolic volume (20 ± 11%), stroke volume (40 ± 12%) and ejection fraction (13 ± 9%) hamper the comparability of RT-MRI results with those of other cardiac MRI methods. Yet, the underestimations were very consistent (< 5% variability) for repetitive measurements, making RT-MRI an appropriate alternative to cine MRI for longitudinal studies. In addition, RT-MRI enabled the analysis of cardio-respiratory coupling. All functional parameters showed lower values during expiration compared to inspiration, most likely due to the pressure-controlled artificial ventilation. In conclusion, despite systematic underestimation of the functional parameters, RT-MRI allowed the assessment of left ventricular function in macaques with significantly less experimental effort, measurement time, risk and burden for the animals compared to cine MRI.

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Free-Breathing 3D Cardiac MRI Using Iterative Image-Based Respiratory Motion Correction

Magnetic Resonance in Medicine ◽

10.1002/mrm.24538 ◽

2012 ◽

Vol 70 (4) ◽

pp. 1005-1015 ◽

Cited By ~ 11

Author(s):

Mehdi H. Moghari ◽

Sébastien Roujol ◽

Raymond H. Chan ◽

Susie N. Hong ◽

Natalie Bello ◽

...

Keyword(s):

Cardiac Mri ◽

Motion Correction ◽

Respiratory Motion ◽

Free Breathing ◽

Respiratory Motion Correction

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Accuracy of short-axis cardiac MRI automatically derived from scout acquisitions in free-breathing and breath-holding modes

Magnetic Resonance Materials in Physics Biology and Medicine ◽

10.1007/s10334-004-0073-5 ◽

2005 ◽

Vol 18 (1) ◽

pp. 7-18 ◽

Cited By ~ 12

Author(s):

M. G. Danilouchkine ◽

J. J. M. Westenberg ◽

J. H. C. Reiber ◽

B. P. F. Lelieveldt

Keyword(s):

Cardiac Mri ◽

Free Breathing ◽

Breath Holding ◽

Short Axis

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Motion corrected compressed sensing for free-breathing dynamic cardiac MRI

Magnetic Resonance in Medicine ◽

10.1002/mrm.24463 ◽

2012 ◽

Vol 70 (2) ◽

pp. 504-516 ◽

Cited By ~ 91

Author(s):

Muhammad Usman ◽

David Atkinson ◽

Freddy Odille ◽

Christoph Kolbitsch ◽

Ghislain Vaillant ◽

...

Keyword(s):

Compressed Sensing ◽

Cardiac Mri ◽

Free Breathing

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Motion correction of free-breathing magnetic resonance renography using model-driven registration

Magnetic Resonance Materials in Physics Biology and Medicine ◽

10.1007/s10334-021-00936-x ◽

2021 ◽

Author(s):

Dimitra Flouri ◽

Daniel Lesnic ◽

Constantina Chrysochou ◽

Jehill Parikh ◽

Peter Thelwall ◽

...

Keyword(s):

Motion Correction ◽

Ground Truth ◽

Free Breathing ◽

Patient Data ◽

Reference Object ◽

Free Form ◽

Model Driven ◽

Time Courses ◽

Signal Time ◽

Parametric Maps

Abstract Introduction Model-driven registration (MDR) is a general approach to remove patient motion in quantitative imaging. In this study, we investigate whether MDR can effectively correct the motion in free-breathing MR renography (MRR). Materials and methods MDR was generalised to linear tracer-kinetic models and implemented using 2D or 3D free-form deformations (FFD) with multi-resolution and gradient descent optimization. MDR was evaluated using a kidney-mimicking digital reference object (DRO) and free-breathing patient data acquired at high temporal resolution in multi-slice 2D (5 patients) and 3D acquisitions (8 patients). Registration accuracy was assessed using comparison to ground truth DRO, calculating the Hausdorff distance (HD) between ground truth masks with segmentations and visual evaluation of dynamic images, signal-time courses and parametric maps (all data). Results DRO data showed that the bias and precision of parameter maps after MDR are indistinguishable from motion-free data. MDR led to reduction in HD (HDunregistered = 9.98 ± 9.76, HDregistered = 1.63 ± 0.49). Visual inspection showed that MDR effectively removed motion effects in the dynamic data, leading to a clear improvement in anatomical delineation on parametric maps and a reduction in motion-induced oscillations on signal-time courses. Discussion MDR provides effective motion correction of MRR in synthetic and patient data. Future work is needed to compare the performance against other more established methods.

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Comparison of Compressed Sensing and Gradient and Spin-Echo in Breath-Hold 3D MR Cholangiopancreatography: Qualitative and Quantitative Analysis

Diagnostics ◽

10.3390/diagnostics11040634 ◽

2021 ◽

Vol 11 (4) ◽

pp. 634

Author(s):

Weon Jang ◽

Ji Soo Song ◽

Sang Heon Kim ◽

Jae Do Yang

Keyword(s):

Image Quality ◽

Compressed Sensing ◽

Spin Echo ◽

Contrast Ratio ◽

Rank Test ◽

Breath Holding ◽

Breath Hold ◽

Background Suppression ◽

Time Saving ◽

Noise Ratio

While magnetic resonance cholangiopancreatography (MRCP) is routinely used, compressed sensing MRCP (CS-MRCP) and gradient and spin-echo MRCP (GRASE-MRCP) with breath-holding (BH) may allow sufficient image quality with shorter acquisition times. This study qualitatively and quantitatively compared BH-CS-MRCP and BH-GRASE-MRCP and evaluated their clinical effectiveness. Data from 59 consecutive patients who underwent both BH-CS-MRCP and BH-GRASE-MRCP were qualitatively analyzed using a five-point Likert-type scale. The signal-to-noise ratio (SNR) of the common bile duct (CBD), contrast-to-noise ratio (CNR) of the CBD and liver, and contrast ratio between periductal tissue and the CBD were measured. Paired t-test, Wilcoxon signed-rank test, and McNemar’s test were used for statistical analysis. No significant differences were found in overall image quality or duct visualization of the CBD, right and left 1st level intrahepatic duct (IHD), cystic duct, and proximal pancreatic duct (PD). BH-CS-MRCP demonstrated higher background suppression and better visualization of right (p = 0.004) and left 2nd level IHD (p < 0.001), mid PD (p = 0.003), and distal PD (p = 0.041). Image quality degradation was less with BH-GRASE-MRCP than BH-CS-MRCP (p = 0.025). Of 24 patients with communication between a cyst and the PD, 21 (87.5%) and 15 patients (62.5%) demonstrated such communication on BH-CS-MRCP and BH-GRASE-MRCP, respectively. SNR, contrast ratio, and CNR of BH-CS-MRCP were higher than BH-GRASE-MRCP (p < 0.001). Both BH-CS-MRCP and BH-GRASE-MRCP are useful imaging methods with sufficient image quality. Each method has advantages, such as better visualization of small ducts with BH-CS-MRCP and greater time saving with BH-GRASE-MRCP. These differences allow diverse choices for visualization of the pancreaticobiliary tree in clinical practice.

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