Gastric motility is a major factor in cold restraint-induced lesion formation in rats

1986 ◽  
Vol 250 (2) ◽  
pp. G191-G199 ◽  
Author(s):  
T. Garrick ◽  
S. Buack ◽  
P. Bass

These studies were performed to characterize the pattern of gastric contractility associated with cold restraint-induced lesion formation. Gastric motility in the rat was examined with extraluminal transducers at three sites of the stomach. The motility was monitored in the 24-h-fasted state, the postprandial state, and during cold-water immersion restraint. Gastric acid secretion was also monitored in a separate group of animals placed in cold restraint. Both feeding and cold restraint resulted in an equivalent increase in the amplitude of gastric contractions. Prolonged cold restraint, however, resulted in a distinct contractile pattern in which contractions were 56% less frequent and 300-400% longer in duration than those stimulated by feeding. All cold-restrained animals developed multiple gastric erosions. Cold restraint was not associated with increased acid secretion. A single subcutaneous injection of papaverine HCl (50 or 100 mg/kg) suppressed cold restraint-induced high-amplitude contractions and the cold restraint-induced lesion formation without altering acid secretion. These studies suggest that the stimulation of high-amplitude, prolonged duration contractions are more important than changes in gastric acid secretion in the formation of cold restraint-induced gastric lesions.

1987 ◽  
Vol 32 (11) ◽  
pp. 1261-1267 ◽  
Author(s):  
Thomas Garrick ◽  
Yoshiaki Goto ◽  
Sally Buack ◽  
Paul Guth

Gut ◽  
1990 ◽  
Vol 31 (5) ◽  
pp. 518-521 ◽  
Author(s):  
G M Fullarton ◽  
E J Boyd ◽  
G P Crean ◽  
T E Hilditch ◽  
K E McColl

2022 ◽  
Vol 12 ◽  
Author(s):  
Chenyu Li ◽  
Hongzhao Sun ◽  
Yuan Shi ◽  
Yan Yu ◽  
Xiaofeng Ji ◽  
...  

Background: Hydrogen sulfide (H2S) is a new type of gas neurotransmitter discovered in recent years. It plays an important role in various physiological activities. The hypothalamus paraventricular nucleus (PVN) is an important nucleus that regulates gastric function. This study aimed to clarify the role of H2S in the paraventricular nucleus of the hypothalamus on the gastric function of rats.Methods: An immunofluorescence histochemistry double-labelling technique was used to determine whether cystathionine-beta-synthase (CBS) and c-Fos neurons are involved in PVN stress. Through microinjection of different concentrations of NaHS, physiological saline (PS), D-2-Amino-5-phosphonovaleric acid (D-AP5), and pyrrolidine dithiocarbamate (PDTC), we observed gastric motility and gastric acid secretion.Results: c-Fos and CBS co-expressed the most positive neurons after 1 h of restraint and immersion, followed by 3 h, and the least was at 0 h. After injection of different concentrations of NaHS into the PVN, gastric motility and gastric acid secretion in rats were significantly inhibited and promoted, respectively (p < 0.01); however, injection of normal saline, D-AP5, and PDTC did not cause any significant change (p > 0.05). The suppressive effect of NaHS on gastrointestinal motility and the promotional effect of NaHS on gastric acid secretion could be prevented by D-AP5, a specific N-methyl-D-aspartic acid (NMDA) receptor antagonist, and PDTC, an NF-κB inhibitor.Conclusion: There are neurons co-expressing CBS and c-Fos in the PVN, and the injection of NaHS into the PVN can inhibit gastric motility and promote gastric acid secretion in rats. This effect may be mediated by NMDA receptors and the NF-κB signalling pathway.


1987 ◽  
Vol 40 (3) ◽  
pp. 357-361 ◽  
Author(s):  
Iwao Arai ◽  
Haruko Hirose ◽  
Makoto Muramatsu ◽  
Hironaka Aihara

Sign in / Sign up

Export Citation Format

Share Document