Sympathoexcitatory input from hypothalamic paraventricular nucleus neurons projecting to rostral ventrolateral medulla is enhanced after myocardial infarction

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00273.2020 ◽

2020 ◽

Vol 319 (6) ◽

pp. H1197-H1207

Author(s):

Satoshi Koba ◽

Eri Hanai ◽

Nao Kumada ◽

Tatsuo Watanabe

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Central Nervous System ◽

Nervous System ◽

Paraventricular Nucleus ◽

Rostral Ventrolateral Medulla ◽

Hypothalamic Paraventricular Nucleus ◽

Ventrolateral Medulla

Using optogenetics in rats, we report that sympathoexcitatory input from hypothalamic paraventricular nucleus neurons that project to the rostral ventrolateral medulla is enhanced after myocardial infarction. It is suggested that this monosynaptic pathway makes up a key part of central nervous system circuitry underlying sympathetic hyperactivation commonly seen in heart failure.

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Sex Differences in Expression of Methionine Sulfoxide Reductase A in Hypothalamic Paraventricular Nucleus in Rats with Heart Failure after Myocardial Infarction

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.564.2 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Yang Yu ◽

Balyssa B Bell ◽

Robert M Weiss ◽

Shun‐Guang Wei ◽

Robert B Felder

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Sex Differences ◽

Paraventricular Nucleus ◽

Methionine Sulfoxide ◽

Hypothalamic Paraventricular Nucleus ◽

Methionine Sulfoxide Reductase ◽

Methionine Sulfoxide Reductase A

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Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are activated by haemorrhage

Brain Research ◽

10.1016/s0006-8993(98)00140-1 ◽

1998 ◽

Vol 791 (1-2) ◽

pp. 317-320 ◽

Author(s):

Emilio Badoer ◽

Jennifer Merolli

Keyword(s):

Paraventricular Nucleus ◽

Rostral Ventrolateral Medulla ◽

Hypothalamic Paraventricular Nucleus ◽

Ventrolateral Medulla

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Microglial activation induced by LPS mediates excitation of neurons in the hypothalamic paraventricular nucleus projecting to the rostral ventrolateral medulla

BMB Reports ◽

10.5483/bmbrep.2021.54.12.105 ◽

2021 ◽

Vol 54 (12) ◽

pp. 620-625

Author(s):

Tae Hee Han ◽

Heow Won Lee ◽

Eun A Kang ◽

Min Seok Song ◽

So Yeong Lee ◽

...

Keyword(s):

Paraventricular Nucleus ◽

Microglial Activation ◽

Rostral Ventrolateral Medulla ◽

Hypothalamic Paraventricular Nucleus ◽

Ventrolateral Medulla

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HYPOTHALAMIC PARAVENTRICULAR NUCLEUS PLAYS A ROLE IN ACUPUNCTURE ANALGESIA THROUGH THE CENTRAL NERVOUS SYSTEM IN THE RAT

Acupuncture & Electro-Therapeutics Research ◽

10.3727/036012992816357639 ◽

1992 ◽

Vol 17 (4) ◽

pp. 209-220 ◽

Author(s):

Yang Jun ◽

Bao-Cheng Lin

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Paraventricular Nucleus ◽

Hypothalamic Paraventricular Nucleus ◽

Acupuncture Analgesia ◽

The Central Nervous System

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Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat

Brain Research ◽

10.1016/s0006-8993(98)00587-3 ◽

1998 ◽

Vol 801 (1-2) ◽

pp. 239-243 ◽

Author(s):

Anthony D Shafton ◽

Andrew Ryan ◽

Emilio Badoer

Keyword(s):

Spinal Cord ◽

Paraventricular Nucleus ◽

Rostral Ventrolateral Medulla ◽

Hypothalamic Paraventricular Nucleus ◽

Ventrolateral Medulla

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Superoxide Is Involved in the Central Nervous System Activation and Sympathoexcitation of Myocardial Infarction–Induced Heart Failure

Circulation Research ◽

10.1161/01.res.0000112964.40701.93 ◽

2004 ◽

Vol 94 (3) ◽

pp. 402-409 ◽

Author(s):

Timothy E. Lindley ◽

Marc F. Doobay ◽

Ram V. Sharma ◽

Robin L. Davisson

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Central Nervous System ◽

Nervous System ◽

The Central Nervous System ◽

System Activation

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Influence of the hypothalamic paraventricular nucleus on cardiovascular neurones in the rostral ventrolateral medulla of the rat

The Journal of Physiology ◽

10.1111/j.1469-7793.1998.521bb.x ◽

1998 ◽

Vol 513 (2) ◽

pp. 521-530 ◽

Author(s):

Z. Yang ◽

J. H. Coote

Keyword(s):

Paraventricular Nucleus ◽

Rostral Ventrolateral Medulla ◽

Hypothalamic Paraventricular Nucleus ◽

Ventrolateral Medulla

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Water deprivation activates a glutamatergic projection from the hypothalamic paraventricular nucleus to the rostral ventrolateral medulla

The Journal of Comparative Neurology ◽

10.1002/cne.20835 ◽

2005 ◽

Vol 494 (4) ◽

pp. 673-685 ◽

Author(s):

Sean D. Stocker ◽

Johnny R. Simmons ◽

Ruth L. Stornetta ◽

Glenn M. Toney ◽

Patrice G. Guyenet

Keyword(s):

Paraventricular Nucleus ◽

Water Deprivation ◽

Rostral Ventrolateral Medulla ◽

Hypothalamic Paraventricular Nucleus ◽

Ventrolateral Medulla

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Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are not activated by hypotension

Brain Research ◽

10.1016/s0006-8993(98)00560-5 ◽

1998 ◽

Vol 801 (1-2) ◽

pp. 224-227 ◽

Author(s):

Emilio Badoer

Keyword(s):

Paraventricular Nucleus ◽

Rostral Ventrolateral Medulla ◽

Hypothalamic Paraventricular Nucleus ◽

Ventrolateral Medulla

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Effects of exercise on BDNF-TrkB signaling in the paraventricular nucleus and rostral ventrolateral medulla in rats post myocardial infarction

Neuropeptides ◽

10.1016/j.npep.2020.102058 ◽

2020 ◽

Vol 82 ◽

pp. 102058

Author(s):

Heow Won Lee ◽

Monir Ahmad ◽

Hong-Wei Wang ◽

Frans H.H. Leenen

Keyword(s):

Myocardial Infarction ◽

Paraventricular Nucleus ◽

Rostral Ventrolateral Medulla ◽

Post Myocardial Infarction ◽

Ventrolateral Medulla

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