Sodium and left ventricular mass in untreated hypertensive and normotensive subjects

1992 ◽  
Vol 263 (1) ◽  
pp. H177-H181 ◽  
Author(s):  
G. Du Cailar ◽  
J. Ribstein ◽  
J. P. Daures ◽  
A. Mimran
Keyword(s):  
Essential Hypertension ◽  
Arterial Pressure ◽  
Left Ventricular Mass ◽  
Sodium Excretion ◽  
Systolic Arterial Pressure ◽  
Urinary Sodium Excretion ◽  
Left Ventricular ◽  
Urinary Sodium ◽  
Ventricular Mass ◽  
Normotensive Subjects

To determine whether urinary sodium excretion (a rather rough estimate of sodium intake) can influence left ventricular mass independently of arterial pressure, 91 untreated subjects with essential hypertension and 50 normotensive subjects of similar age were studied. Left ventricular mass index (M-mode echocardiography) was positively correlated with urinary sodium excretion in hypertensive (r = 0.22, P less than 0.01) as well as normotensive subjects (r = 0.22, P less than 0.05), and systolic arterial pressure was correlated only in hypertensive subjects (r = 0.23, P less than 0.01). When hypertensive subjects were divided into groups with appropriate or inappropriate left ventricular mass by reference to a theoretical optimal left ventricular mass for each subject's level of systolic arterial pressure, left ventricular mass was appropriate in 68% and inappropriate in 32% of subjects. Urinary sodium excretion was higher in subjects with inappropriate left ventricular mass compared with those with appropriate left ventricular mass. In conclusion, sodium excretion may be an important modulator of the influence of arterial pressure on the left ventricle in normotensive subjects and subjects with essential hypertension.

Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2

2005 ◽  
Vol 23 (6) ◽  
pp. 1149-1157 ◽  
Author(s):  
Mako Isaji ◽  
Tomoatsu Mune ◽  
Nobuki Takada ◽  
Yoritsuna Yamamoto ◽  
Tetsuya Suwa ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Sodium Excretion ◽  
Urinary Sodium Excretion ◽  
Left Ventricular ◽  
Urinary Sodium ◽  
Ventricular Mass

scholarly journals Arterial Pressure, Left Ventricular Mass, and Aldosterone in Essential Hypertension

Hypertension ◽  
2001 ◽  
Vol 37 (3) ◽  
pp. 845-850 ◽  
Author(s):  
Areeg H. El-Gharbawy ◽  
Vishwanatha S. Nadig ◽  
Jane Morley Kotchen ◽  
Clarence E. Grim ◽  
Kiran B. Sagar ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Arterial Pressure ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Ventricular Mass

An analysis of the DOCA-salt model of hypertension in HO-1−/− mice and the Gunn rat

2007 ◽  
Vol 293 (1) ◽  
pp. H333-H342 ◽  
Author(s):  
Karl A. Nath ◽  
Livius V. d'Uscio ◽  
Julio P. Juncos ◽  
Anthony J. Croatt ◽  
Melissa C. Manriquez ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Sodium Excretion ◽  
Systolic Arterial Pressure ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
Systemic Hypertension ◽  
Heme Oxygenase 1 ◽  
Wild Type ◽  
Gunn Rat ◽  
Gunn Rats

Heme oxygenase-1 (HO-1) is induced in the vasculature in the DOCA-salt model of hypertension in rats. Whereas the HO system and its products may exert vasodilator effects, recent studies have suggested that the HO system may predispose to hypertension. The present study examined the effects of selected components of the HO system, specifically, the HO-1 isozyme and the product bilirubin in the DOCA-salt model of systemic hypertension; the experimental approach employed mutant rodent models, namely, the HO-1−/− mouse and the hyperbilirubinemic Gunn rat. DOCA-salt induced HO-1 protein in the aorta in HO-1+/+ mice and provoked a significant rise in systolic arterial pressure in HO-1−/− mice but not in HO-1+/+ mice; this effect could not be ascribed to impaired urinary sodium excretion or impaired glomerular filtration rate in the DOCA-salt-treated HO-1−/− mice. The administration of DOCA salt to uninephrectomized rats significantly increased systolic arterial pressure in wild-type rats, an effect that was attenuated in the mutant Gunn rat; this reduction in systemic hypertension in the DOCA-salt-treated Gunn rat was not due to a greater induction of HO-1 in the vasculature or to a more avid urinary sodium excretion. DOCA-salt impaired endothelium-dependent and endothelium-independent vasorelaxation in wild-type rats but not in Gunn rats; prior exposure to bilirubin repaired the defect in endothelium-dependent vasorelaxation in aortic rings in DOCA-salt-treated rats. DOCA salt stimulated vascular production of superoxide anion in wild-type but not in Gunn rats. We suggest that HO-1 and the product bilirubin may exert a countervailing effect in the DOCA-salt model of systemic hypertension.

Is Anp-Cyclic GMP Coupling a Determinant of Urinary Sodium Excretion in Essential Hypertension?

1992 ◽  
Vol 82 (s26) ◽  
pp. 29P-29P
Author(s):  
G.A. Sagnella ◽  
D.R.J. Singer ◽  
N.D. Markandu ◽  
M.G. Buckley ◽  
G.A. MacGregor
Keyword(s):  
Essential Hypertension ◽  
Cyclic Gmp ◽  
Sodium Excretion ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium

Comparison of Left Ventricular Mass and Geometry in Black and White Patients With Essential Hypertension

1993 ◽  
Vol 6 (10) ◽  
pp. 815-823 ◽  
Author(s):  
Michael J. Koren ◽  
George A. Mensah ◽  
James Blake ◽  
John H. Laragh ◽  
Richard B. Devereux
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Black And White ◽  
Ventricular Mass ◽  
White Patients

Effects of hypoproteinemia on renal hemodynamics, arterial pressure, and fluid volume

1987 ◽  
Vol 252 (1) ◽  
pp. F91-F98
Author(s):  
R. D. Manning
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Sodium Excretion ◽  
Sodium Intake ◽  
Renal Plasma Flow ◽  
Urinary Sodium Excretion ◽  
Renal Hemodynamics ◽  
Fluid Volume ◽  
Urinary Sodium ◽  
Plasma Aldosterone Concentration

The effects of long-term hypoproteinemia on renal hemodynamics, arterial pressure, and fluid volume were studied in eight conscious dogs over a 34-day period. Plasma protein concentration (PPC) was decreased by daily plasmapheresis, and the effects of decreasing and increasing sodium intake were measured. By the 12th day of plasmapheresis, during which sodium intake was 30 meq/day, PPC had decreased to 2.5 g/dl from a control value of 7.2 g/dl, mean arterial pressure had decreased to 78% of control, glomerular filtration rate (GFR) was 75.2% of control, and urinary sodium excretion was decreased. By day 18 of plasmapheresis, estimated renal plasma flow (ERPF) was decreased to 60% of control due to the decreased arterial pressure and an increase in renal vascular resistance. Also, plasma renin activity and plasma aldosterone concentration were both increased, and the relationship between mean arterial pressure and urinary sodium excretion was distinctly shifted to the left along the arterial pressure axis. In contradistinction to acute experiments, chronic hypoproteinemia results in decreases in GFR, ERPF, and urinary sodium excretion and has marked effects on both fluid volume and arterial pressure regulation.

Homocysteine, Adrenergic Activity and Left Ventricular Mass in Patients with Essential Hypertension

2002 ◽  
Vol 11 (4) ◽  
pp. 201-205 ◽  
Author(s):  
Bożenna Wocial ◽  
Hanna Berent ◽  
Maciej Kostrubiec ◽  
Krystyna Kuczyńska ◽  
Agnieszka Kuch-Wocial ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Adrenergic Activity
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