Relationship of maximal tubular phosphate reabsorption to dietary phosphate in the dog

1964 ◽  
Vol 207 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Dorothea Hellman ◽  
H. Robert Baird ◽  
Frederic C. Bartter
Keyword(s):  
Filtration Rate ◽  
Normal Values ◽  
Normal Diet ◽  
Tubular Reabsorption ◽  
The Body ◽  
Tubular Phosphate Reabsorption ◽  
Renal Tubular Reabsorption ◽  
Dietary Phosphate ◽  
Renal Tubular ◽  
Relationship Of

In normal dogs, the maximal tubular reabsorption of phosphate (Tmp) on moderate phosphate (P) intake has been compared to that on high P intake. Oral P loading caused a reduction in glomerular filtration rate (GFR) in all the animals. A significant reduction in Tmp could be demonstrated in five of the six dogs while on sustained oral P loading. This decline in Tmp was significantly greater than could be accounted for by the regression of Tmp on GFR. A return toward normal values for TmP occurred following resumption of a normal diet. The reduction in Tmp during oral P loading suggests that a reduction in renal tubular reabsorption of phosphate (TRP) is one means whereby excess phosphate is eliminated from the body. This reduction in TRP may be related to an increased release of endogenous parathyroid hormone.

scholarly journals Erythropoietin down-regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate in humans

2011 ◽  
Vol 589 (6) ◽  
pp. 1273-1281 ◽  
Author(s):  
Niels Vidiendal Olsen ◽  
Niels-Jacob Aachmann-Andersen ◽  
Peter Oturai ◽  
Thor Munch-Andersen ◽  
Andreas Bornø ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Tubular Reabsorption ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular

Renal Tubular Reabsorption of Inorganic Sulfate in the Dog, as Affected by Glomerular Filtration Rate and Sodium Chloride

1956 ◽  
Vol 185 (3) ◽  
pp. 533-538 ◽  
Author(s):  
Fredrik Berglund ◽  
William D. Lotspeich
Keyword(s):  
Glomerular Filtration Rate ◽  
Sodium Chloride ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Chloride Ions ◽  
Tubular Reabsorption ◽  
Glomerular Filtrate ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular ◽  
Inorganic Sulfate

The sulfate Tm varies in the dog directly with the glomerular filtration rate. Sulfate Tm is markedly depressed by the intravenous injection of as little as 0.1 gm sodium chloride/kg body weight. Maximum depression is obtained first 50 minutes after the injection. Xylose, urea and mannitol have no effect on sulfate Tm. The effect of sodium chloride is therefore not due to an osmotic action, but seems to depend on an increased level of sodium or chloride ions in the glomerular filtrate.

Relationship of maximal tubular phosphate reabsorption to filtration rate in the dog

1964 ◽  
Vol 207 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Dorothea Hellman ◽  
H. Robert Baird ◽  
Frederic C. Bartter
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Direct Relationship ◽  
Considerable Variability ◽  
Phosphate Reabsorption ◽  
Wide Range ◽  
Tubular Phosphate Reabsorption ◽  
Renal Tubular ◽  
Relationship Of

A maximal renal tubular rate of reabsorption of phosphate (Tmp) has been demonstrated in the normal dog. In the dog, as in the man, considerable variability in the Tmp often occurs. While some of this variability remains unexplained, a direct relationship between glomerular filtration rate (GFR) and Tmp can be demonstrated when the GFR is varied over a wide range. This relationship suggests that glomerular intermittency may exist in the dog.

scholarly journals Early post-transplantation hypophosphatemia is associated with elevated FGF-23 levels

2011 ◽  
Vol 164 (5) ◽  
pp. 839-847 ◽  
Author(s):  
Andrea Trombetti ◽  
Laura Richert ◽  
Karine Hadaya ◽  
Jean-Daniel Graf ◽  
François R Herrmann ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Tubular Reabsorption ◽  
Phosphate Metabolism ◽  
Multivariate Models ◽  
Intact Pth ◽  
Post Transplantation ◽  
Estimated Gfr ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular ◽  
Fgf 23

BackgroundWe examined the hypothesis that high FGF-23 levels early after transplantation contribute to the onset of hypophosphatemia, independently of parathyroid hormone (PTH) and other factors regulating phosphate metabolism.MethodsWe measured serum phosphate levels (sPi), renal tubular reabsorption of Pi (TmPi/GFR), estimated GFR (eGFR), intact PTH (iPTH), calcitriol, intact (int) and C-terminal (Cter) FGF-23, dietary Pi intake and cumulative doses of glucocorticoids in 69 patients 12 days (95% confidence interval, 10–13) after renal transplantation.ResultsHypophosphatemia was observed in 43 (62%) of the patients 12 days after transplantation. Compared with non-hypophosphatemic subjects, their post-transplantation levels of intact and CterFGF-23 were higher (195 (108–288) vs 48 (40–64) ng/l, P<0.002 for intFGF-23; 205 (116–384) vs 81 (55–124) U/ml, P<0.002, for CterFGF-23). In all subjects, Cter and intFGF-23 correlated inversely with sPi (r=−0.35, P<0.003; −0.35, P<0.003, respectively), and TmPi/GFR (r=−0.50, P<0.001; −0.54, P<0.001, respectively). In multivariate models, sPi and TmPi/GFR were independently associated with FGF-23, iPTH and eGFR. Pre-transplant iPTH levels were significantly higher in patients developing hypophosphatemia after renal transplantation. Pre-transplant levels of FGF-23 were not associated with sPi at the time of transplantation.ConclusionIn addition to PTH, elevated FGF-23 may contribute to hypophosphatemia during the early post-renal transplant period.

Renal filtration and excretion of aluminium in the rat: dose-response relationships and effects of aluminium speciation

1995 ◽  
Vol 14 (6) ◽  
pp. 494-499 ◽  
Author(s):  
CJ Lote ◽  
JA Wood ◽  
A. Thewles ◽  
M. Freeman
Keyword(s):  
Filtration Rate ◽  
Rat Plasma ◽  
Tubular Reabsorption ◽  
The Body ◽  
Aluminium Sulphate ◽  
Renal Handling ◽  
Aluminium Speciation ◽  
Aluminium Citrate ◽  
Aluminium Species ◽  
Filtered Load

The known toxicity of aluminium, and the toxicity of agents (such as desferrioxamine) used to remove alumini um from the body, has prompted us to investigate whether there may be ways of enhancing aluminium excretion by exploiting the normal renal handling of aluminium. Aluminium (as sulphate or citrate) was administered intravenously to conscious rats at doses ranging from 25 μg (0.93 μmol) to 800 μg (29.6 μmol) aluminium, and alu minium excretion was monitored over the following 2 h. Measurements of the filterability of aluminium from the rat plasma, and the glomerular filtration rate (inulin clearance), enabled us to calculate the filtered load of alu minium, and hence determine aluminium reabsorption. At all doses of administered aluminium, that adminis tered as sulphate was excreted less effectively than that administered as citrate. This difference was attributable to the much greater filterability of aluminium administered as citrate. However, for any given filtered load, the excre tion of aluminium administered as citrate was not signifi cantly different (in either fractional or absolute terms) from the excretion of aluminium administered as sulphate. It seems likely that, following aluminium sulphate administration, the filtered aluminium may be an alumini um citrate form which is then reabsorbed in the same way as aluminium administered as citrate. It is thus apparent that aluminium removal from the body could be further enhanced if it were possible to pre vent the tubular reabsorption of the aluminium species which is so effectively filtered following aluminium citrate administration.

Renal tubular reabsorption of trace alkaline earths compared with calcium

1965 ◽  
Vol 208 (6) ◽  
pp. 1165-1170 ◽  
Author(s):  
W. Joseph Rahill ◽  
Mackenzie Walser
Keyword(s):  
Protein Binding ◽  
Transport Mechanism ◽  
Tubular Reabsorption ◽  
Constant Infusion ◽  
Constant Power ◽  
Calcium Clearance ◽  
Renal Tubular Reabsorption ◽  
Order Of Magnitude ◽  
Alkaline Earths ◽  
Renal Tubular

Simultaneous clearances of inulin, calcium, and either Be7, Ba140, or Ra226, given by constant infusion, were measured in salt-depleted dogs or dogs undergoing mild saline, mannitol, or sulfate diuresis. Urine-to-plasma ratios of all three cations less than 0.5 were noted, suggesting that all can be actively reabsorbed. Clearances of barium and radium were correlated with calcium clearance, but the clearance of beryllium was unpredictable. Protein binding of beryllium was shown to be of the same order of magnitude as other alkaline earths when errors due to adsorption of Be7 onto containers were minimized. Protein binding of barium averaged 54%. The excreted-to-filtered ratio for barium was a constant power (.54) of the ratio for calcium. The data do not exclude the possibility that these cations are reabsorbed by a common transport mechanism with calcium.

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