Mechanism of diuresis during negative pressure breathing

1959 ◽  
Vol 14 (1) ◽  
pp. 116-120 ◽  
Author(s):  
John W. Boylan ◽  
Dorothy E. Antkowiak
Keyword(s):  
Negative Pressure ◽  
Hormone Secretion ◽  
Free Water ◽  
Effective Mechanism ◽  
Water Diuresis ◽  
Antidiuretic Hormone Secretion ◽  
Clearance Studies ◽  
Negative Pressure Breathing ◽  
Solute Excretion ◽  
Osmolar Concentration

The diuresis associated with negative pressure breathing in moderately hydrated man is found to be due chiefly to an increase in the excretion of free water; solute excretion rises slightly and consistently. Simultaneous clearance studies do not reveal a characteristic pattern in renal hemodynamics for diuresis is observed to attend an increase, decrease or absence of change in RPF and GFR. There is, moreover, no effect on the peripheral venous hematocrit nor on the osmolar concentration of the plasma. Negative pressure breathing is without effect on urine flow when performed during maximal water diuresis or during the antidiuresis produced by infused Pitressin. These observations are in accord with the theory that the effective mechanism for the diuresis of negative pressure breathing is a reflex inhibition of antidiuretic hormone secretion. Submitted on September 19, 1958

INHIBITION OF ANTIDIURETIC HORMONE SECRETION BY INTRACAROTID INFUSIONS OF SLIGHTLY HYPERTONIC NON-ELECTROLYTE SOLUTIONS

1974 ◽  
Vol 76 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Kerstin Olsson ◽  
Rigmor Kolmodin
Keyword(s):  
Renal Clearance ◽  
Antidiuretic Hormone ◽  
Arginine Vasopressin ◽  
Hormone Secretion ◽  
Free Water ◽  
Electrolyte Solutions ◽  
Nacl Solution ◽  
Water Diuresis ◽  
Receptor System ◽  
Antidiuretic Hormone Secretion

ABSTRACT Relatively rapid (3.75 ml/min), unilateral intracarotid infusions of slightly hypertonic (0.35 m) galactose and glycerol solutions induced a water diuresis within 40 to 60 min in the non-hydrated goat. The response to equi-osmolal fructose solution was weaker and less consistent. The water diuresis was apparently due to an inhibition of the basic ADH secretion, since it could be inhibited temporarily by the administration of small amounts of arginine vasopressin. The corresponding intracarotid infusion of isotonic NaCl solution did not significantly alter the renal clearance of free water, nor did equivalent intrajugular infusions of the non-electrolyte solutions induce water diuresis. The results appear incompatible with the osmoreceptor theory, and support the assumption that a central, Na+ sensitive receptor system may be involved in the regulation of the ADH secretion.

Effect of forward acceleration on renal function

1962 ◽  
Vol 17 (3) ◽  
pp. 413-416 ◽  
Author(s):  
John F. Watson ◽  
Rita M. Rapp
Keyword(s):  
Negative Pressure ◽  
Human Subjects ◽  
Renal Plasma Flow ◽  
Urine Volume ◽  
Free Water ◽  
Free Water Clearance ◽  
Water Excretion ◽  
Normal Human ◽  
Negative Pressure Breathing ◽  
Water Clearance

The effect of forward acceleration on renal hemodynamics, electrolyte excretion, and water clearance has been studied in six normal human subjects. Forward acceleration produced a slight increase in glomerular filtration rate and effective renal plasma flow during and after stress. After centrifugation there was a 20–35-min lag before the appearance of an increase in urine volume and free water clearance. These changes in water excretion were transient and were not accompanied by a natriuresis nor associated with changes in serum osmolality. Physiologic responses to forward acceleration and negative pressure breathing were compared. It was suggested that forward acceleration, like negative pressure breathing, may induce an increase in intrathoracic blood volume which inhibits the release of antidiuretic hormone via a nonosmotic volume-sensitive receptor mechanism located within the intrathoracic vascular space. Submitted on September 14, 1961

Sympathetic nerve activity and renal responses during continuous negative-pressure breathing in humans

1991 ◽  
Vol 261 (2) ◽  
pp. R276-R282 ◽  
Author(s):  
H. Tanaka ◽  
S. Sagawa ◽  
K. Miki ◽  
F. Tajima ◽  
B. J. Freund ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Free Water ◽  
Nerve Activity ◽  
Free Water Clearance ◽  
Negative Pressure Breathing ◽  
Cardiopulmonary Receptors ◽  
Renal Responses

A stretch stimulus of the cardiopulmonary receptors results in a diuresis and natriuresis in dogs due to a suppression of renal sympathetic nerve activity. In the present experiment, the stretch stimulus in humans was given by means of continuous negative-pressure breathing (CNPB), and muscle sympathetic nerve activity (MSNA), renal responses, and hormones were measured to examine whether MSNA response during CNPB correlated with the usual renal and hormonal responses for stretch stimulus of the cardiopulmonary receptors. Nine healthy males were subjected to CNPB at -11 mmHg for 60 min. MSNA in the peroneal muscle nerve fascicles was measured continuously before (pre-CNPB), during, and after CNPB (post-CNPB). A step and sustained decrease (P less than 0.05) in MSNA (30 +/- 6% for burst frequency and 37 +/- 4% for total activity from pre-CNPB level) was observed during CNPB and it returned to pre-CNPB level at post-CNPB. Urinary excretion increased by 58 +/- 18% (P less than 0.05) during CNPB, and the diuresis was entirely osmolal in nature because of a significant increase (P less than 0.05) in Na excretion and a constant free-water clearance. The plasma level of norepinephrine decreased significantly (P less than 0.05) during CNPB and remained decreased (P less than 0.05) at post-CNPB. A twofold increase (P less than 0.05) in plasma atrial natriuretic peptide and a 35 +/- 9% reduction (P less than 0.05) in plasma renin activity were observed during CNPB, whereas no change was observed in plasma aldosterone and arginine vasopressin.(ABSTRACT TRUNCATED AT 250 WORDS)

An experimental model of syndrome of inappropriate antidiuretic hormone secretion in the rat

1984 ◽  
Vol 247 (4) ◽  
pp. E540-E553 ◽  
Author(s):  
J. G. Verbalis
Keyword(s):  
Experimental Model ◽  
Antidiuretic Hormone ◽  
Arginine Vasopressin ◽  
Hormone Secretion ◽  
Extracellular Fluid ◽  
Free Water ◽  
Urinary Flow ◽  
Water Excretion ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

An experimental model of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was developed using continuous subcutaneous infusions of arginine vasopressin (AVP) or 1-desamino-8-D-arginine vasopressin (DDAVP) in conscious unrestrained rats drinking 5% dextrose solution. Retention of both ingested water and endogenously generated free water from tissue catabolism was the primary determinant of hyponatremia using either AVP or DDAVP infusions. Natriuresis occurred transiently following water expansion but only slightly further lowered plasma [Na+]. Cessation of antidiuretic infusion resulted in free water excretion with correction of plasma [Na+]. Erythrocyte cell volume was significantly increased in hyponatremic animals and intracellular [K+] and [Na+] both decreased equivalently, consistent with dilution of intracellular fluid by retained water. This model of SIADH differs significantly from those previously described, in that escape from the hydroosmotic effect of AVP and DDAVP does not occur in the absence of high urinary flow rates. The observed results using this model suggest that the retained water in SIADH primarily resides intracellularly following isotonic equilibration of extracellular fluid volume.

scholarly journals Small cell carcinoma of the cervix complicated by syndrome of inappropriate antidiuretic hormone secretion: a case report

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098565
Author(s):  
Cai-Fu Zhao ◽  
Su-Fen Zhao ◽  
Ze-Qing Du
Keyword(s):  
Cell Carcinoma ◽  
Antidiuretic Hormone ◽  
Small Cell Carcinoma ◽  
Poor Prognosis ◽  
Hormone Secretion ◽  
Clinical Manifestations ◽  
Small Cell ◽  
Laboratory Examination ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

Small cell carcinoma of the cervix is a rare malignant tumor in the clinical setting. Clinical manifestations of this tumor are mostly similar to those of normal types of cervical cancer. Small cell carcinoma of the cervix only shows symptoms of neuroendocrine tumors, such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Most of the hyponatremia caused by SIADH can be managed after removal of the cause. Hyponatremia is a predictor of poor prognosis and can be used as an indicator of partial recurrence. We report a case of small cell carcinoma of the cervix complicated by SIADH. Our patient presented with irregular vaginal bleeding after menopause. After one cycle of chemotherapy, there was trembling of the limbs, and a laboratory examination showed low Na+ and low Cl− levels. After limited water intake, intravenous hypertonic saline, and intermittent diuretic treatment, the patient’s blood Na+ levels returned to normal. After a radical operation, the above-mentioned symptoms disappeared.

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