Differential inspiratory timing is genetically linked to mouse chromosome 3

1998 ◽  
Vol 85 (1) ◽  
pp. 360-365 ◽  
Author(s):  
C. G. Tankersley ◽  
D. A. DiSilvestre ◽  
A. E. Jedlicka ◽  
H. M. Wilkins ◽  
L. Zhang
Keyword(s):  
Quantitative Trait Locus ◽  
Mouse Chromosome ◽  
Dna Markers ◽  
Quantitative Trait ◽  
Chromosome 3 ◽  
Phenotypic Variance ◽  
Putative Quantitative Trait Locus ◽  
Strain Distribution Pattern ◽  
Log Likelihood ◽  
Trait Locus

Genetic control of differential inspiratory timing (Ti) at baseline has been previously demonstrated among inbred mouse strains. The inheritance pattern for Ti between C3H/HeJ (C3; 188 ± 3 ms) and C57BL/6J (B6; 111 ± 2 ms) progenitors was consistent with a two-gene model. By using the strain distribution pattern for recombinant inbred strains derived from C3 and B6 progenitors, 100% concordance was established between Ti phenotypes and DNA markers on mouse chromosome 3. This genotype-phenotype hypothesis was tested by typing 52 B6C3F2(F2) progeny by using simple sequence repeat DNA markers ( n = 21) polymorphic between C3 and B6 strains on mouse chromosome 3. Linkage analysis compared marker genotypes to baseline ventilatory phenotypes by computing log-likelihood values. A putative quantitative trait locus located in proximity to D3Mit119 was significantly associated with baseline Ti phenotypes. At the peak (log-likelihood = 3.3), the putative quantitative trait locus determined 25% of the phenotypic variance in Ti among F2 progeny. In conclusion, this genetic model of ventilatory characteristics demonstrated an important linkage between differential baseline Ti and a candidate genomic region on mouse chromosome 3.

A major quantitative trait locus on mouse chromosome 3 is involved in disease susceptibility in different colitis models

2005 ◽  
Vol 128 (1) ◽  
pp. 74-85 ◽  
Author(s):  
Michelle E.A. Borm ◽  
Jianping He ◽  
Brian Kelsall ◽  
A. Salvador Peña ◽  
Warren Strober ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Mouse Chromosome ◽  
Quantitative Trait ◽  
Major Quantitative Trait Locus ◽  
Disease Susceptibility ◽  
Chromosome 3 ◽  
Trait Locus

scholarly journals A Novel Quantitative Trait Locus on Mouse Chromosome 18, “era1,” Modifies the Entrainment of Circadian Rhythms

SLEEP ◽  
2007 ◽  
Vol 30 (10) ◽  
pp. 1255-1263 ◽  
Author(s):  
Jonathan P. Wisor ◽  
Martin Striz ◽  
Jason DeVoss ◽  
Greer M. Murphy ◽  
Dale M. Edgar ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Circadian Rhythms ◽  
Mouse Chromosome ◽  
Quantitative Trait ◽  
Chromosome 18 ◽  
Trait Locus

scholarly journals Inheritance and Identification of a Major Quantitative Trait Locus (QTL) that Confers Resistance to Meloidogyne incognita and a Novel QTL for Plant Height in Sweet Sorghum

2015 ◽  
Vol 105 (12) ◽  
pp. 1522-1528 ◽  
Author(s):  
Karen R. Harris-Shultz ◽  
Richard F. Davis ◽  
Joseph E. Knoll ◽  
William Anderson ◽  
Hongliang Wang
Keyword(s):  
Quantitative Trait Locus ◽  
Resistance Gene ◽  
Meloidogyne Incognita ◽  
Quantitative Trait ◽  
Sweet Sorghum ◽  
Major Quantitative Trait Locus ◽  
Interval Mapping ◽  
Chromosome 3 ◽  
Trait Locus ◽  
Stalk Weight

Southern root-knot nematodes (Meloidogyne incognita) are a pest on many economically important row crop and vegetable species and management relies on chemicals, plant resistance, and cultural practices such as crop rotation. Little is known about the inheritance of resistance to M. incognita or the genomic regions associated with resistance in sorghum (Sorghum bicolor). In this study, an F2 population (n = 130) was developed between the resistant sweet sorghum cultivar ‘Honey Drip’ and the susceptible sweet cultivar ‘Collier’. Each F2 plant was phenotyped for stalk weight, height, juice Brix, root weight, total eggs, and eggs per gram of root. Strong correlations were observed between eggs per gram of root and total eggs, height and stalk weight, and between two measurements of Brix. Genotyping-by-sequencing was used to generate single nucleotide polymorphism markers. The G-Model, single marker analysis, interval mapping, and composite interval mapping were used to identify a major quantitative trait locus (QTL) on chromosome 3 for total eggs and eggs per gram of root. Furthermore, a new QTL for plant height was also discovered on chromosome 3. Simple sequence repeat markers were developed in the total eggs and eggs per gram of root QTL region and the markers flanking the resistance gene are 4.7 and 2.4 cM away. These markers can be utilized to move the southern root-knot nematode resistance gene from Honey Drip to any sorghum line.

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