Vibration decreases the responsiveness of Ia afferents and spinal motoneurons in humans

2021 ◽  
Vol 126 (4) ◽  
pp. 1137-1147
Author(s):  
Mitsuhiro Nito ◽  
Takuya Yoshimoto ◽  
Wataru Hashizume ◽  
Masaomi Shindo ◽  
Akira Naito
Keyword(s):  
Recovery Time ◽  
Spinal Motoneurons ◽  
Postsynaptic Inhibition ◽  
Depressive Effect ◽  
Ia Afferents ◽  
Presynaptic Effect

Vibration decreased the responsiveness of Ia afferents from the muscle exposed to vibration, and the duration of depressive effect was modulated by the duration and frequency of the vibration: a longer duration and a higher frequency of vibration led to a longer recovery time of the depression. In addition to this presynaptic effect, it also depressed the responsiveness of spinal motoneurons, indicating postsynaptic inhibition through specific circuits triggered by Ia impulses.

Expedited Resolution of 5-Fluorouracil-Induced Erythema and Barrier Dysfunction with White Petrolatum

2019 ◽  
Vol 3 (4) ◽  
pp. 279-282
Author(s):  
Melody Maarouf ◽  
Bryan Kromenacker ◽  
Eric Brucks ◽  
Vivian Shi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Wound Healing ◽  
Recovery Time ◽  
Patient Adherence ◽  
Precancerous Lesions ◽  
Transepidermal Water Loss ◽  
Petroleum Jelly ◽  
Barrier Dysfunction ◽  
Exposed Skin ◽  
Risk Of Progression

Actinic keratoses (AK) are precancerous lesions that develop on chronically sun-exposed skin. They frequently require prophylactic field treatment due to the risk of progression to squamous cell carcinoma. Topical treatment with 5-fluorouracil (5-FU) yields near complete AK resolution, yet leaves a patient with an exuberant erythematous treatment site, which may be embarrassing and/or uncomfortable. We report a case of a patient with diffuse facial AK who was treated with 5-FU twice daily for 2 weeks, resulting in fiery-red erythema and disrupted barrier indices. Application of pure ultra white petroleum jelly, an emollient preferred by dermatologists for post-operative wound healing, resulted in drastic decreased erythema and recovery time of post-treatment transepidermal water loss and hydration, compared to the contralateral, non-petrolatum-treated side. Additionally, petrolatum use did not disrupt the AK resolution endpoint. We suggest that petroleum jelly be used for the repair of 5-FU-induced barrier disruption and erythema to promote greater patient adherence. 

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