scholarly journals Th1/Th2 Cytokine Ratio in Tissue Transudates from Patients with Oral Lichen Planus

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
Nelson L. Rhodus ◽  
Bin Cheng ◽  
Frank Ondrey
Keyword(s):  
Disease Activity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lesion ◽  
Tnf Alpha ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Oral Fluids ◽  
Therapeutic Decisions ◽  
Oral Lichen

Objective. The characteristics of oral lichen planus (OLP) provoke investigators to explore possible biomarkers by which to monitor disease activity and therapeutic efficacy. Oral fluids may provide an accessible medium for analysis of such biomarkers. Previous studies have shown that activation of nuclear factor-kappa B (NF-κB) plays an important role in the pathogenesis of oral lichen planus (OLP), which is a chronic inflammatory disorder mediated by T cells. Prior to the present investigation, reports of the levels of NF-κB and its dependent cytokines in oral fluids have not been forthcoming. The purpose of this study was to detect the level of NF-κB dependent cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in tissue transudates directly from lesions of OLP, and explore the feasibility of the data for clinical application.Study design. Thirteen definitively diagnosed OLP subjects were enrolled in the study as were 13 age-sex matched controls. In each subject, lesion tissue transudates (TTs) were collected by a novel collection technique with a filter paper. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids were determined by ELISA.Results. In the tissue transudate(TT), there were significantly higher level of cytokines TNF-alpha, IL-1-alpha, IL-6, and IL-8 detected in OLP patients than in controls: (TT:40.0±9.8versus4.5±0.7,710±114versus305±78,150±25versus1.7±0.5,2800±260versus1450±130,P<.0001; unit: pg/mL).Conclusions. These results indicate that NF-κB dependent inflammatory cytokines may be detected at increased levels in oral lesion tissue transudates which may have diagnostic and prognostic potentials for monitoring disease activity and making therapeutic decisions in patients with OLP.

A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients

2005 ◽  
Vol 114 (3) ◽  
pp. 278-283 ◽  
Author(s):  
Nelson L. Rhodus ◽  
Bin Cheng ◽  
Sandra Myers ◽  
Walter Bowles ◽  
Vu Ho ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Tnf Alpha ◽  
Oral Fluids ◽  
Oral Lichen

Expression of TNF-alpha in oral lichen planus treated with fluocinolone acetonide 0.1%

2006 ◽  
Vol 35 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Kobkan Thongprasom ◽  
Kittipong Dhanuthai ◽  
Wilairat Sarideechaigul ◽  
Ponlatham Chaiyarit ◽  
Mantharop Chaimusig
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Fluocinolone Acetonide ◽  
Tnf Alpha ◽  
Oral Lichen

Elevated serum levels of the apoptosis related molecules TNF-alpha, Fas/Apo-1 and Bcl-2 in oral lichen planus

2004 ◽  
Vol 33 (7) ◽  
pp. 386-390 ◽  
Author(s):  
A. Sklavounou-Andrikopoulou ◽  
E. Chrysomali ◽  
M. Iakovou ◽  
G. A. Garinis ◽  
A. Karameris
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Elevated Serum ◽  
Serum Levels ◽  
Tnf Alpha ◽  
Oral Lichen

TNF-alpha expression and apoptosis-regulating proteins in oral lichen planus: a comparative immunohistochemical evaluation

2000 ◽  
Vol 29 (8) ◽  
pp. 370-375 ◽  
Author(s):  
Alexandra Sklavounou ◽  
Evanthia Chrysomali ◽  
Andreas Scorilas ◽  
Andreas Karameris
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Tnf Alpha ◽  
Oral Lichen

FOXP3+ T regulatory cells in lesions of oral lichen planus correlated with disease activity

Oral Diseases ◽  
2010 ◽  
Vol 16 (1) ◽  
pp. 76-82 ◽  
Author(s):  
X-a Tao ◽  
J Xia ◽  
X-b Chen ◽  
H Wang ◽  
Y-h Dai ◽  
...  
Keyword(s):  
Disease Activity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
T Regulatory Cells ◽  
Regulatory Cells ◽  
Oral Lichen

scholarly journals Association of Oral Lichen Planus and Electrocardiographic P-Wave Dispersion - An Original Research

2017 ◽  
Vol 28 (6) ◽  
pp. 699-703
Author(s):  
R. Aditi ◽  
S. Sathasivasubramanian ◽  
M. Emmanuel Bhaskar
Keyword(s):  
Atrial Fibrillation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Wave Dispersion ◽  
P Wave ◽  
Original Research ◽  
Inflammatory Disorder ◽  
P Wave Dispersion ◽  
Surface Ecg ◽  
Oral Lichen

Abstract Lichen planus (LP) is considered to be a T-cell-mediated inflammatory disorder. Inflammation is considered to produce disturbances of lipid metabolism which may affect the myocardium. Increased P-Wave Dispersion (PWD) is demonstrated as an independent risk factor for developing atrial fibrillation (AF). Hence the present study has been conducted to explore the possible relationship of oral lichen planus (OLP) with AF by the evaluation of PWD. Twelve-lead electrocardiographs (ECG) were obtained from 45 OLP patients and 45 age and gender-matched healthy controls. The P-wave durations (Pmax and Pmin) were calculated in all 12 leads. The difference between Pmax and Pmin was defined as P-Wave Dispersion (PWD). After the PWD was recorded, the results were statistically analyzed. The study showed that PWD increased on surface ECG measurements in OLP patients who were otherwise asymptomatic in relation to cardiac conditions. The p value obtained was <0.001 which was highly significant. The present study suggests a highly statistically significant association of OLP with increased P-wave dispersion. Hence the patients with OLP should undergo cardiac evaluation and follow up for early detection of atrial fibrillation.

scholarly journals Pigmented Oral Lichen Planus: A Case Report

2017 ◽  
Vol 1 (1) ◽  
pp. 11
Author(s):  
Firstine Kelsi Hartanto ◽  
Thomas George Kallarakal
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Diagnostic Process ◽  
Clinical Feature ◽  
Inflammatory Disorder ◽  
Predisposing Factor ◽  
Oral Lichen

<p><strong>Background:</strong> Lichen planus is a chronic muccocutaneous inflammatory disorder. Oral lichen planus (OLP) has certain specific characteristics in its clinical presentation, but can also be presented in forms resembling other diseases. This may introduce difficulty in the diagnostic process. It has been reported that OLP affects between 0.1 to 4% individuals, predominantly women and people over 40 years old. <strong>Case Report:</strong> A 46-year-old woman complained of a non-healing ulcer present for 1.5 months. Intraorally, multiple white striae with prominent central areas of brownish hyperpigmentation were apparent on the right and left buccal mucosa, right and left buccal sulcus, and lateral and dorsum of the tongue. A biopsy was completed and the histopathology features confirmed the diagnosis of OLP. For the initial treatment, a topical corticosteroid was prescribed, followed by steroid mouthwash. Response to this treatment was positive. OLP has been frequently reported to affect women over the age of 40, with psychological stress as a primary predisposing factor. The clinical presentation is characteristic of Wickham’s striae with erosive areas. However, a biopsy and histopathological examination is mandatory to confirm the diagnosis. The clinical feature of pigmented OLP has been reported and confirmed by microscopic finding of band-like lymphocytic appearance which is the pathognomonic features of OLP, along with basal cell liquefaction degeneration, and melanin in continence at the lamina propria. <strong>Conclusion:</strong> Pigmented OLP is a variant of erosive OLP. Anamnesis, clinical presentation, and histopathological examination confirm diagnosis.</p>

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