Elevated serum levels of the apoptosis related molecules TNF-alpha, Fas/Apo-1 and Bcl-2 in oral lichen planus

2004 ◽  
Vol 33 (7) ◽  
pp. 386-390 ◽  
Author(s):  
A. Sklavounou-Andrikopoulou ◽  
E. Chrysomali ◽  
M. Iakovou ◽  
G. A. Garinis ◽  
A. Karameris
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Elevated Serum ◽  
Serum Levels ◽  
Tnf Alpha ◽  
Oral Lichen

scholarly journals Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Maryam Mardani ◽  
Hossein Mofidi ◽  
Ladan Dastgheib ◽  
Sara Ranjbar ◽  
Nasrin Hamidizadeh
Keyword(s):  
Lichen Planus ◽  
Crucial Role ◽  
Oral Lichen Planus ◽  
Elevated Serum ◽  
Serum Levels ◽  
Chronic Inflammatory Disease ◽  
Healthy Controls ◽  
Cytokine Network ◽  
Interleukin 23 ◽  
Oral Lichen

Lichen planus is considered a chronic inflammatory disease which affects different sites, such as the skin, mucous membranes, hair, and nails. Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. The study was aimed at assessing the serum IL-23 levels in the patients with cutaneous and oral lichen planus compared to healthy controls. Method. The study included 30 cutaneous lichen planus patients, 20 oral lichen planus patients, and 33 control subjects. Five milliliters of peripheral blood was obtained from each patient, and the serum was separated. IL-23 levels were determined using the ELISA kit, and the data were analyzed using the Mann–Whitney test. Results. IL-23 levels in the patient serum with oral lichen planus ( P value ≤ 0.001) were significantly higher than in controls. Furthermore, there were significant differences in IL-23 serum levels in the patients with cutaneous lichen planus compared to the healthy controls ( P value ≤ 0.001). Moreover, IL-23 serum levels were statistically different between patients with cutaneous lichen planus and patients with oral lichen planus ( P value ≤ 0.001). Based on the mean concentration of interleukin-23, IL-23 levels were higher in the patients with oral lichen planus than in the patients with cutaneous lichen planus. Conclusions. Elevated serum IL-23 levels in the patients with oral lichen planus may indicate that IL-23 plays a crucial role in the pathogenesis of oral lichen planus. However, more research is needed with a larger sample size.

Evaluation of the serum levels of galectin-3 in patients with oral lichen planus disease

Oral Diseases ◽  
2019 ◽  
Vol 25 (2) ◽  
pp. 466-470 ◽  
Author(s):  
Janan Ghapanchi ◽  
Azadeh Andisheh-Tadbir ◽  
Pooriya Torkaman ◽  
Mahyar Malekzadeh ◽  
Maryam Mardani
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Serum Levels ◽  
Galectin 3 ◽  
Oral Lichen

scholarly journals Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

2018 ◽  
Author(s):  
Hamid Reza Mozaffari ◽  
Elisa Zavattaro ◽  
Abas Abdolahnejad ◽  
Pia Lopez Jornet ◽  
Neda Omidpanah ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Serum Levels ◽  
Inflammatory Factors ◽  
Cochrane Library ◽  
Healthy Controls ◽  
Case Control Studies ◽  
Salivary Iga ◽  
Oral Lichen

Background and Aim: Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Materials and Methods: Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the NOS questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Results: Out of 70 studies found in the databases, eight studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of  IgA, IgG, and IgM were -0.13 g/L [95%CI: -0.24, -0.02; P = 0.02], 1.01 g/L [95%CI: -0.91, 2.93; P = 0.30], and -0.06 g/L [95%CI: -0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95%CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95%CI: -0.20, 1.38; P = 0.14], respectively. Conclusions: Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had a higher diagnostic value than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

scholarly journals Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

Medicina ◽  
2018 ◽  
Vol 54 (6) ◽  
pp. 99 ◽  
Author(s):  
Hamid Mozaffari ◽  
Elisa Zavattaro ◽  
Abas Abdolahnejad ◽  
Pia Lopez-Jornet ◽  
Neda Omidpanah ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Serum Levels ◽  
Inflammatory Factors ◽  
Cochrane Library ◽  
Healthy Controls ◽  
Case Control Studies ◽  
Salivary Iga ◽  
Oral Lichen

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the Newcastle–Ottawa Quality Assessment Scale (NOS) questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Out of 70 studies found in the databases, 8 studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of IgA, IgG, and IgM were −0.13 g/L [95% CI: −0.24, −0.02; P = 0.02], 1.01 g/L [95% CI: −0.91, 2.93; P = 0.30], and −0.06 g/L [95% CI: −0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95% CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95% CI: −0.20, 1.38; P = 0.14], respectively. Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had higher values than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

Effect of Use of Propolis on Serum Levels of Il-17 and Clinical Symptoms and Signs in Patients with Ulcerative Oral Lichen Planus

2015 ◽  
Vol 119 (3) ◽  
pp. e166-e167
Author(s):  
Ali Taghavi Zenouz ◽  
Masoumeh Mehdipour ◽  
Reza Tavakoli Ata Abadi ◽  
Javad Shokri ◽  
Mehrangiz Rajaee ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Symptoms ◽  
Serum Levels ◽  
Oral Lichen ◽  
Symptoms And Signs

Expression of TNF-alpha in oral lichen planus treated with fluocinolone acetonide 0.1%

2006 ◽  
Vol 35 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Kobkan Thongprasom ◽  
Kittipong Dhanuthai ◽  
Wilairat Sarideechaigul ◽  
Ponlatham Chaiyarit ◽  
Mantharop Chaimusig
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Fluocinolone Acetonide ◽  
Tnf Alpha ◽  
Oral Lichen

IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus

Oral Diseases ◽  
2017 ◽  
Vol 24 (3) ◽  
pp. 377-383 ◽  
Author(s):  
LA Gueiros ◽  
T Arão ◽  
T Souza ◽  
CL Vieira ◽  
RS Gomez ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Serum Levels ◽  
Oral Lichen

scholarly journals Th1/Th2 Cytokine Ratio in Tissue Transudates from Patients with Oral Lichen Planus

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
Nelson L. Rhodus ◽  
Bin Cheng ◽  
Frank Ondrey
Keyword(s):  
Disease Activity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lesion ◽  
Tnf Alpha ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Oral Fluids ◽  
Therapeutic Decisions ◽  
Oral Lichen

Objective. The characteristics of oral lichen planus (OLP) provoke investigators to explore possible biomarkers by which to monitor disease activity and therapeutic efficacy. Oral fluids may provide an accessible medium for analysis of such biomarkers. Previous studies have shown that activation of nuclear factor-kappa B (NF-κB) plays an important role in the pathogenesis of oral lichen planus (OLP), which is a chronic inflammatory disorder mediated by T cells. Prior to the present investigation, reports of the levels of NF-κB and its dependent cytokines in oral fluids have not been forthcoming. The purpose of this study was to detect the level of NF-κB dependent cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in tissue transudates directly from lesions of OLP, and explore the feasibility of the data for clinical application.Study design. Thirteen definitively diagnosed OLP subjects were enrolled in the study as were 13 age-sex matched controls. In each subject, lesion tissue transudates (TTs) were collected by a novel collection technique with a filter paper. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids were determined by ELISA.Results. In the tissue transudate(TT), there were significantly higher level of cytokines TNF-alpha, IL-1-alpha, IL-6, and IL-8 detected in OLP patients than in controls: (TT:40.0±9.8versus4.5±0.7,710±114versus305±78,150±25versus1.7±0.5,2800±260versus1450±130,P<.0001; unit: pg/mL).Conclusions. These results indicate that NF-κB dependent inflammatory cytokines may be detected at increased levels in oral lesion tissue transudates which may have diagnostic and prognostic potentials for monitoring disease activity and making therapeutic decisions in patients with OLP.

scholarly journals Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Fahimeh Rezazadeh ◽  
Sara Haghighat
Keyword(s):  
Immune System ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Serum Levels ◽  
Control Group ◽  
Related Disorder ◽  
Significant Difference ◽  
The Difference ◽  
Southwest Of Iran ◽  
Oral Lichen

Introduction. Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3, and E in OLP patients. Methods and Materials. 34 OLP patients referred to Shiraz Dental School entered the study. Blood samples were collected and levels of A, B12, C, D3, and E vitamins were measured in serum. 43 healthy people were also included as the control group. Serum levels of vitamins were measured by HPLC (A, B12, D3, and E) and Kiazist analyzing kit (vitamin C). Results. Most of the patients were female (62.3%), and the mean age of patients was 48.03 ± 11.57 . Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; however, the difference was not significant. Vitamins B12 and D3 were higher in the OLP group but the difference was not significant. Conclusion. Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups. These vitamins may not have a considerable role in OLP pathogenesis in the southwest of Iran.

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