scholarly journals Optimal Control for Multistage Nonlinear Dynamic System of Microbial Bioconversion in Batch Culture

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Lei Wang ◽  
Zhilong Xiu ◽  
Yuduo Zhang ◽  
Enmin Feng

In batch culture of glycerol biodissimilation to 1,3-propanediol (1,3-PD), the aim of adding glycerol is to obtain as much 1,3-PD as possible. Taking the yield intensity of 1,3-PD as the performance index and the initial concentration of biomass, glycerol, and terminal time as the control vector, we propose an optimal control model subject to a multistage nonlinear dynamical system and constraints of continuous state. A computational approach is constructed to seek the solution of the above model. Firstly, we transform the optimal control problem into the one with fixed terminal time. Secondly, we transcribe the optimal control model into an unconstrained one based on the penalty functions and an extension of the state space. Finally, by approximating the control function with simple functions, we transform the unconstrained optimal control problem into a sequence of nonlinear programming problems, which can be solved using gradient-based optimization techniques. The convergence analysis and optimality function of the algorithm are also investigated. Numerical results show that, by employing the optimal control, the concentration of 1,3-PD at the terminal time can be increased, compared with the previous results.

2009 ◽  
Vol 45 (11) ◽  
pp. 1621-1635 ◽  
Author(s):  
N. L. Grigorenko ◽  
D. V. Kamzolkin ◽  
L. N. Luk’yanova ◽  
D. G. Pivovarchuk

2014 ◽  
Vol 2014 ◽  
pp. 1-19 ◽  
Author(s):  
Baba Seidu ◽  
Oluwole D. Makinde

A nonlinear dynamical system is proposed and qualitatively analyzed to study the dynamics of HIV/AIDS in the workplace. The disease-free equilibrium point of the model is shown to be locally asymptotically stable if the basic reproductive number,R0, is less than unity and the model is shown to exhibit a unique endemic equilibrium when the basic reproductive number is greater than unity. It is shown that, in the absence of recruitment of infectives, the disease is eradicated whenR0<1, whiles the disease is shown to persist in the presence of recruitment of infected persons. The basic model is extended to include control efforts aimed at reducing infection, irresponsibility, and nonproductivity at the workplace. This leads to an optimal control problem which is qualitatively analyzed using Pontryagin’s Maximum Principle (PMP). Numerical simulation of the resulting optimal control problem is carried out to gain quantitative insights into the implications of the model. The simulation reveals that a multifaceted approach to the fight against the disease is more effective than single control strategies.


Author(s):  
S.V. Konstantinov ◽  
A.I. Diveev

A new approach is considered to solving the problem of synthesizing an optimal control system based on the extremals' set approximation. At the first stage, the optimal control problem for various initial states out of a given domain is being numerically sold. Evolutionary algorithms are used to solve the optimal control problem numerically. At the second stage, the problem of approximating the found set of extremals by the method of symbolic regression is solved. Approach considered in the work makes it possible to eliminate the main drawback of the known approach to solving the control synthesis problem using the symbolic regression method, which consists in the fact that the genetic algorithm used in solving the synthesis problem does not provide information about proximity of the found solution to the optimal one. Here, control function is built on the basis of a set of extremals; therefore, any particular solution should be close to the optimal trajectory. Computational experiment is presented for solving the applied problem of synthesizing the four-wheel robot optimal control system in the presence of phase constraints. It is experimentally demonstrated that the synthesized control function makes it possible for any initial state from a given domain to obtain trajectories close to optimal in the quality functional. Initial states were considered during the experiment, both included in the approximating set of optimal trajectories and others from the same given domain. Approximation of the extremals set was carried out by the network operator method


2014 ◽  
Vol 26 (1) ◽  
pp. 1-13 ◽  
Author(s):  
N. L. Grigorenko ◽  
D. V. Kamzolkin ◽  
L. N. Luk’yanova ◽  
D. G. Pivovarchuk

Author(s):  
Amine Hamdache ◽  
Smahane Saadi ◽  
Ilias Elmouki

In this work, an optimal control approach is presented in order to propose an optimal therapy for the treatment HIV infection using a combination of two appropriate treatment strategies. The optimal treatment duration and the optimal medications amount are considered. The main objective of this study is to be able to maximize the benet based on number of healthy CD4+ T-cells and CTL immune cells and to minimize the infection level and the overall treatment cost while optimizing the duration of therapy. The free terminal time optimal control problem is formulated and the Pontryagin's maximum principle is employedto provide the explicit formulations of the optimal controls. The corresponding optimality system with the additional transversality condition for the terminal time is derived and solved numerically using an adapted iterative method with a Runge-Kutta fourth order scheme and a gradient method routine.


2018 ◽  
Vol 41 (8) ◽  
pp. 2280-2292 ◽  
Author(s):  
Xiang Wu ◽  
Jinxing Lin ◽  
Kanjian Zhang ◽  
Ming Cheng

This paper considers an optimal advertising strategy problem. This is an important problem in marketing investment for new products in a free market. The main contributions of this paper are as follows. First, the problem is formulated as an optimal control problem of switched impulsive systems with the state inequality constraints, which is different from the existing nonlinear system models. As the complexity of such constraints and the switching instants are unknown, it is difficult to solve this problem by using conventional optimization techniques. To overcome this difficulty, by applying the penalty function, all the state inequality constraints are first written as non-differentiable penalty terms and imposed into the cost function. Then, the penalty terms are smoothed by using a novel smooth function, leading to a smooth optimal control problem with no state inequality constraints, and an improved gradient-based particle swarm optimization (PSO) algorithm is proposed for solving this problem. Error analysis results show that if the adjustable parameter is sufficiently small, the solution of the smooth optimal control problem is approximately equal to the original problem. Finally, a switched impulsive system for beer sales is established to illustrate the effectiveness of the developed algorithm.


2014 ◽  
Vol 51 (02) ◽  
pp. 333-345 ◽  
Author(s):  
Philip A. Ernst ◽  
Dean P. Foster ◽  
Larry A. Shepp

We pose an optimal control problem arising in a perhaps new model for retirement investing. Given a control function f and our current net worth X(t) for any t, we invest an amount f(X(t)) in the market. We need a fortune of M ‘superdollars’ to retire and want to retire as early as possible. We model our change in net worth over each infinitesimal time interval by the Itô process dX(t) = (1 + f(X(t)))dt + f(X(t))dW(t). We show how to choose the optimal f = f 0 and show that the choice of f 0 is optimal among all nonanticipative investment strategies, not just among Markovian ones.


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