Specific EEG Changes Associated with Atrophy of Hippocampus in Subjects with Mild Cognitive Impairment and Alzheimer's Disease

We evaluated the association between hippocampal atrophy and increase of the EEG markers alpha3/alpha2 relative power ratio in mild cognitive impairment (MCI) and Alzheimer's disease patients. Seventy-nine subjects with MCI and 11 patients with AD underwent EEG recording and MRI scan. The MCI group was subdivided in three subgroups according to growing hippocampal atrophy. The groups were characterized by alpha3/alpha2 relative power ratio. In AD patients group mapped hippocampal regions were computed and related with alpha3/alpha2 power ratio. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of hippocampus both in MCI and in Alzheimer's disease patients. This finding confirms the possible diagnostic role of EEG markers as diagnostic and prognostic factors in patient with prodromal and declared Alzheimer's disease.

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Volumetric Differences in Mapped Hippocampal Regions Correlate with Increase of High Alpha Rhythm in Alzheimer's Disease

International Journal of Alzheimer s Disease ◽

10.4061/2011/208218 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 11

Author(s):

D. V. Moretti ◽

A. Prestia ◽

C. Fracassi ◽

C. Geroldi ◽

G. Binetti ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Alpha Rhythm ◽

Hippocampal Atrophy ◽

Alpha Power ◽

Power Ratio ◽

Diagnostic Role

Objective. The increase of high alpha relative to low alpha power has been recently demonstrated as a reliable EEG marker of hippocampal atrophy conversion of patients with mild cognitive impairment (MCI) in Alzheimer's disease (AD). In the present study we test the reliability of this EEG index in subjects with AD.Methods. Correlation between EEG markers and volumetric differences in mapped hippocampal regions was estimated in AD patients.Results. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of mapped hippocampal regions in Alzheimer's disease.Conclusions. The findings confirm the possible diagnostic role of EEG markers.

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Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

NeuroImage ◽

10.1016/j.neuroimage.2008.10.043 ◽

2009 ◽

Vol 45 (1) ◽

pp. S3-S15 ◽

Cited By ~ 151

Author(s):

Jonathan H. Morra ◽

Zhuowen Tu ◽

Liana G. Apostolova ◽

Amity E. Green ◽

Christina Avedissian ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Hippocampal Atrophy ◽

Automated Mapping

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The Role of Dietary and Lifestyle Factors in Maintaining Cognitive Health

American Journal of Lifestyle Medicine ◽

10.1177/1559827617701066 ◽

2017 ◽

Vol 12 (4) ◽

pp. 268-285 ◽

Cited By ~ 3

Author(s):

Nathalie E. Marchand ◽

Majken K. Jensen

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Lower Risk ◽

Controlled Trial ◽

Cognitive Health ◽

Healthy Diets ◽

Global Population

Concern over loss of cognitive function, including descent into Alzheimer’s disease or dementia, grips a growing percentage of men and women worldwide as the global population ages. Many studies, though not all, suggest that maintaining cognitive health, as well as slowing and even preventing cognitive decline, dementia, and Alzheimer’s disease, can be achieved by consuming healthy diets over a long enough period of time. This appears to be the case even for those who initiated dietary changes later in life, as evidenced by an intervention study assessing consumption of a healthy diet among those who were >50 years of age. All such diets share the common traits of being rich in fruits, vegetables, whole grains, and fish or seafood, while also being low in red meat and sweets. A Mediterranean-style diet shares these characteristics and has been associated with an estimated 40% lower risk of cognitive impairment, including mild cognitive impairment, dementia, and Alzheimer’s disease in prospective studies, in addition to being associated with both a 65% lower risk of mild cognitive impairment and improved cognitive performance in a notable randomized controlled trial.

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