scholarly journals Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Alex P. Lange ◽  
Reza Sadjadi ◽  
Jameelah Saeedi ◽  
Janette Lindley ◽  
Fiona Costello ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Time Domain ◽  
Disease Duration ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
History Of

Objective. The aim of this study was to compare retinal nerve fiber layer thickness (RNFLT) between spectral-domain (SD-) and time-domain optical coherence tomography (TD-OCT) in MS patients and healthy controls (HC). Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC should be explored. Finally, the relationship between RNFLT, disease duration, EDSS, and disease modifying therapy (DMT) should be established.Design. Prospective, cross-sectional study.Participants. 28 MS patients and 35 HC.Methods. Both groups underwent TD- and SD-OCT measurements. RFNLT was correlated between the two machines and between MS eyes with and without ON and HC. Furthermore, RNFLT was correlated to disease duration, EDSS and DMT.Results. A strong correlation (Pearson’sr=0.921,P<0.001), but a statistically significant difference of 2 μm (P<0.001), was found between the two devices. RNFLT was significantly different between MS eyes with history of ON (mean RFNLT (SD) 72.21 μm (15.83 μm)), MS eyes without history of ON 93.03 μm (14.25 μm), and HC 99.07 μm (7.23 μm) (P<0.001).Conclusions. The measurements between different generation of OCT machines are not interchangeable, which should be taken into account if comparing results between different machines and switching OCT machine in longitudinal studies.

scholarly journals A comparison of retinal nerve fiber layer (RNFL) thickness obtained with frequency and time domain optical coherence tomography (OCT)

2009 ◽  
Vol 17 (5) ◽  
pp. 3997 ◽  
Author(s):  
Donald C. Hood ◽  
Ali S. Raza ◽  
Kristine Y. Kay ◽  
Shlomit F. Sandler ◽  
Daiyan Xin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Time Domain ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

Association of Retinal Nerve Fiber Layer (RNFL) Thickness with Smoking Using Optical Coherence Tomography (OCT) in Pakistani Population

2020 ◽  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
History Of ◽  
Group B ◽  
Retinal Nerve Fiber

Background: Smoking has multisystem effects on human body due to hypoxia and systemic inflammation, which it produces. This contributory effect is observed in ocular tissues as well. The aim of the study was to evaluate retinal nerve fiber layer (RNFL) thickness in healthy individuals with a history of smoking, using optical coherence tomography (OCT). Methods: Patients healthy eyes n=300 were examined. Two groups were made; Group A with history of smoking (n=50) and Group B with no history of smoking (n=250). Subjects with a history of diabetes, hypertension, raised intra ocular pressure (IOP >21 mmHg), any neurological disease or family history of glaucoma were excluded from the study. Independent t-test was used to assess the thickness variation with smoking status. ANOVA was used to analyze the differences in both groups. p value <0.05 was taken as significant. Results: The mean retinal nerve fiber layer (RNFL) thickness was found to be 96.44 ± 9.32 μm in Group A eyes. It was found to be significantly increased (p=0.02) in Group B 99.54 ± 9.32 μm. The mean RNFL thickness 93.52 ± 8.60 μm in smokers with history of more than 10 years was found decreased compared to the thickness 98.66 ± 3.96 μm in those with history of smoking less than 10 years. Conclusion: Retinal nerve fiber layer (RNFL) was found to be decreased in subjects with positive history of smoking. This difference signifies that smoking is associated with ocular pathologies. Future protocols may be included in screening for RNFL thickness in smokers for early detection and prevention of optical diseases. Keywords: Smoking; Retina; Retinal Nerve Fiber Layer (RNFL); Retinal Damage; Optical Coherence Tomography (OCT).

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