scholarly journals Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Byeong-Cheol Ahn ◽  
Won Kee Lee ◽  
Shin Young Jeong ◽  
Sang-Woo Lee ◽  
Jaetae Lee
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Immunoradiometric Assay ◽  
Mathematical Equation ◽  
Excellent Correlation ◽  
Serum Thyroglobulin ◽  
Antithyroglobulin Antibody ◽  
Analytical Interference ◽  
Mathematical Equations ◽  
Thyroglobulin Concentration

We investigated the analytical interference of antithyroglobulin antibody (TgAb) to thyroglobulin (Tg) measurement and tried to convert measured Tg concentration to true Tg concentration using a mathematical equation which includes a concentration of TgAb.Methods.Tg was measured by immunoradiometric assay and TgAb by radioimmunoassy. Experimental samples were produced by mixing Tg and TgAb standard solutions or mixing patients’ serum with high Tg or high TgAb. Mathematical equations for prediction of expected Tg concentration with measured Tg and TgAb concentrations were deduced. The Tg concentration calculated using the equations was compared with the expected Tg concentration.Results.Measured Tg concentrations of samples having high TgAb were significantly lower than their expected Tg concentration. Magnitude of TgAb interference with the Tg assay showed a positive correlation with concentration of TgAb. Mathematical equations for estimation of expected Tg concentration using measured Tg and TgAb concentrations were successfully deduced and the calculated Tg concentration showed excellent correlation with expected Tg concentration.Conclusions.A mathematic equation for estimation of true Tg concentration using measured Tg and TgAb concentration was deduced. Tg concentration calculated by use of the equation might be more valuable than measured Tg concentration in patients with differentiated thyroid cancer.

scholarly journals Comparison of Thyroglobulin Concentrations Measured by Two Immunoradiometric Assay

2020 ◽  
Vol 21 (2) ◽  
pp. 121-125
Author(s):  
Vesna Ignjatovic ◽  
Milovan Matovic ◽  
Vladimir Vukomanovic
Keyword(s):  
Thyroid Cancer ◽  
Statistical Analysis ◽  
Differentiated Thyroid Cancer ◽  
Immunoradiometric Assay ◽  
Serum Thyroglobulin ◽  
Specific Test ◽  
Radioiodine Ablation ◽  
Assay Methods ◽  
Positive Correlation Coefficient ◽  
Good Agreement

AbstractCirculating thyroglobulin measurements is a highly specific test in the management of patients affected by differentiated thyroid cancer after total thyroidectomy, followed by radioiodine ablation. The aim of our study was to compare two thyroglobulinimmunoradiometric assays (INEP, Serbia and Cisbio Bioassays, France). Study included 42 patients of both genders with DTC. The subjects were on suppres¬sive doses of levothyroxine and followed up. Results showed concordance between the two assay methods for determining serum thyroglobulin for 39 (92.85%) patients. Statistical analysis showed that there was a direct correlation between two IRMA tests, with a positive correlation coefficient r=0.613 (p 0.05). We concluded that there is good agreement between the two thyroglobulin assays compared in this study.

The role of preoperative serum thyroglobulin values in the diagnosis of differentiated thyroid cancer

2017 ◽  
Author(s):  
Blertina Dyrmishi ◽  
Taulant Olldashi ◽  
Ema Lumi ◽  
Entela Puca ◽  
Dorina Ylli ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Serum Thyroglobulin ◽  
Preoperative Serum

scholarly journals Antithyroglobulin antibody as a marker of successful ablation therapy in differentiated thyroid cancer

2017 ◽  
Vol 16 (1) ◽  
pp. 15 ◽  
Author(s):  
AyuRosemeilia Dewi ◽  
Budi Darmawan ◽  
AchmadHussein Sundawa Kartamihadja ◽  
Basuki Hidayat ◽  
JohanS Masjhur
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Ablation Therapy ◽  
Antithyroglobulin Antibody ◽  
Successful Ablation
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