scholarly journals Mycobacterium avium Complex-Associated Hemophagocytic Lymphohistiocytosis in a Sickle Cell Patient: An Unusual Fatal Association

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Mohammed A. R. Chamsi-Pasha ◽  
M. Chadi Alraies ◽  
Abdul Hamid Alraiyes ◽  
Eric D. Hsi

Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome, characterized clinically by fever, splenomegaly, cytopenia, and high ferritin. Infectious causes have been associated with secondary HLH, with viruses being the most common. We report a case ofMycobacterium avium complex-associated HLH in a sickle cell anemia patient. To the best of our knowledge, this association has never been reported in sickle cell anemia.

2017 ◽  
Vol 8 (1) ◽  
pp. 54
Author(s):  
JohnAyodele Olaniyi ◽  
AkinyinkaOluwafemi Akinwunmi

Blood ◽  
1989 ◽  
Vol 73 (3) ◽  
pp. 845-848 ◽  
Author(s):  
IS Han ◽  
HJ Huang ◽  
YT Zeng ◽  
KD Lanclos ◽  
TH Huisman

Abstract We have determined the nucleotide sequence of the 2,360-bp long EcoRI fragment from four chromosomes; this fragment is located 3′ to the A gamma globin gene and is considered to contain the enhancer element identified by Bodine and Ley. The chromosomes were from an Arabian sickle cell anemia patient with high Hb F and a homozygosity for haplotype No 31 and from a black sickle cell anemia patient with low Hb F and a homozygosity for haplotype No 19. A third chromosome carried the determinant for a nondeletional hereditary persistence of fetal hemoglobin seen in a Chinese subject, and the fourth was a normal chromosome from a Yugoslavian subject. Twenty-one differences were observed when a comparison was made with the published sequence; no differences were seen between the sequences of the four different samples except for an additional mutation in the Chinese. These data make it unlikely that specific mutations within this sequence are associated with increases in G gamma and A gamma production.


2015 ◽  
Vol 37 (4) ◽  
pp. 272-274
Author(s):  
Aline Cristina Peluccio Martins ◽  
Gisele Sampaio Silva ◽  
Samuel Ademola Adegoke ◽  
Daniela Laranja Gomes Rodrigues ◽  
Josefina Aparecida Pellegrini Braga ◽  
...  

Blood ◽  
1989 ◽  
Vol 73 (3) ◽  
pp. 845-848
Author(s):  
IS Han ◽  
HJ Huang ◽  
YT Zeng ◽  
KD Lanclos ◽  
TH Huisman

We have determined the nucleotide sequence of the 2,360-bp long EcoRI fragment from four chromosomes; this fragment is located 3′ to the A gamma globin gene and is considered to contain the enhancer element identified by Bodine and Ley. The chromosomes were from an Arabian sickle cell anemia patient with high Hb F and a homozygosity for haplotype No 31 and from a black sickle cell anemia patient with low Hb F and a homozygosity for haplotype No 19. A third chromosome carried the determinant for a nondeletional hereditary persistence of fetal hemoglobin seen in a Chinese subject, and the fourth was a normal chromosome from a Yugoslavian subject. Twenty-one differences were observed when a comparison was made with the published sequence; no differences were seen between the sequences of the four different samples except for an additional mutation in the Chinese. These data make it unlikely that specific mutations within this sequence are associated with increases in G gamma and A gamma production.


2017 ◽  
Vol 14 (3) ◽  
pp. 152
Author(s):  
Ibrahim Abdulqadir ◽  
MuhammadAlhaji Ndakotsu ◽  
AbubakarUmar Musa ◽  
Umar Mohammed

2017 ◽  
Vol 5 (8) ◽  
pp. 1218-1221 ◽  
Author(s):  
Caroline C. B. Braga ◽  
Bruno Deltreggia Benites ◽  
Dulcineia M. de Albuquerque ◽  
Marisa C. Alvarez ◽  
Tiago Seva-Pereira ◽  
...  

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