scholarly journals Association between Inflammatory Marker, Environmental Lead Exposure, and Glutathione S-Transferase Gene

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Jintana Sirivarasai ◽  
Winai Wananukul ◽  
Sming Kaojarern ◽  
Suwannee Chanprasertyothin ◽  
Nisakron Thongmung ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Inflammatory Marker ◽  
Blood Lead ◽  
Genetic Determinants ◽  
Glutathione S Transferase ◽  
Environmental Lead ◽  
Gst Polymorphisms ◽  
Gst Polymorphism ◽  
Hs Crp ◽  
Environmental Lead Exposure

A number of studies suggested that lead is related to the induction of oxidative stress, and alteration of immune response. In addition, modifying these toxic effects varied partly by GST polymorphism. The objectives of this study were to assess the association between the lead-induced alteration in serum hs-CRP, with GSTM1, GSTT1, and GSTP1 Val105Ile genetic variations and the health consequence from environmental lead exposure. The 924 blood samples were analyzed for blood lead, CRP, and genotyping of three genes with real-time PCR. Means of blood lead and serum hs-CRP were 5.45 μg/dL and 2.07 mg/L. Both CRP and systolic blood pressure levels were significantly higher for individuals with blood lead in quartile 4 (6.48–24.63 μg/dL) compared with those in quartile 1 (1.23–3.47 μg/dL,P<0.01). In particular, in men with blood lead >6.47 μg/dL the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with wild-type allele was 1.46 (95% CI; 1.05–2.20), 1.32 (95% CI; 1.03–1.69), 1.65 (95% CI; 1.17–2.35), and 1.98 (95% CI; 1.47–2.55), respectively. Our findings suggested that lead exposure is associated with adverse changes in inflammatory marker and SBP. GST polymorphisms are among the genetic determinants related to lead-induced inflammatory response.

scholarly journals Association between inflammatory marker, environmental lead exposure and glutathione S-transferase gene

2013 ◽  
Vol 221 ◽  
pp. S61 ◽  
Author(s):  
Jintana Sirivarasai ◽  
Winai Wananukul ◽  
Sming Kaojarern ◽  
Suwannee Chanprasertyothin ◽  
Nisakron Thongmung ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Inflammatory Marker ◽  
Glutathione S Transferase ◽  
Environmental Lead ◽  
Transferase Gene ◽  
Environmental Lead Exposure

High Lead Exposure Associated With Higher Blood Pressure in Haiti: a Warning Sign for Low-Income Countries

Hypertension ◽  
2021 ◽  
Author(s):  
Lily D. Yan ◽  
Vanessa Rouzier ◽  
Jean Lookens Pierre ◽  
Myung Hee Lee ◽  
Paul Muntner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Lead Exposure ◽  
Lead Level ◽  
Blood Lead ◽  
Lower Income ◽  
Environmental Lead ◽  
Lead Levels ◽  
Environmental Lead Exposure ◽  
Lower Income Countries

Cardiovascular disease is the leading cause of death in lower-income countries including Haiti. Environmental lead exposure is associated with high blood pressure and cardiovascular mortality in high-income countries but has not been systematically measured and evaluated as a potential modifiable cardiovascular risk factor in lower-income countries where 6.5 billion people reside. We hypothesized lead exposure is high in urban Haiti and associated with higher blood pressure levels. Blood lead levels were measured in 2504 participants ≥18 years enrolled in a longitudinal population-based cohort study in Port-au-Prince. Lead screening was conducted using LeadCare II (detection limit ≥3.3 µg/dL). Levels below detection were imputed by dividing the level of detection by √2. Associations between lead (quartiles) and systolic blood pressure and diastolic blood pressure were assessed, adjusting for age, sex, obesity, smoking, alcohol, physical activity, income, and antihypertensive medication use. The median age of participants was 40 years and 60.1% were female. The geometric mean blood lead level was 4.73µg/dL, 71.1% had a detectable lead level and 42.3% had a blood lead level ≥5 µg/dL. After multivariable adjustment, lead levels in quartile four (≥6.5 µg/dL) compared with quartile 1 (<3.4 µg/dL) were associated with 2.42 mm Hg (95% CI, 0.36–4.49) higher systolic blood pressure and 1.96 mm Hg (95% CI, 0.56–3.37) higher diastolic blood pressure. In conclusion, widespread environmental lead exposure is evident in urban Haiti, with higher lead levels associated with higher systolic and diastolic blood pressure. Lead is a current and potentially modifiable pollutant in lower-income countries that warrants urgent public health remediation. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03892265.

scholarly journals Environmental Lead Exposure in Polish Children: Blood Lead Levels, Major Sources and Principles of the Lead Poisoning Prevention

2003 ◽  
Vol 1 (3-4) ◽  
pp. 333-342 ◽  
Author(s):  
Dorota Jarosińska ◽  
Maja Muszyńska-Graca ◽  
Beata Dąbkowska ◽  
Joanna Kasznia-Kocot ◽  
lwona Sakowska-Maliszewska ◽  
...  
Keyword(s):  
Lead Poisoning ◽  
Lead Exposure ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels ◽  
Environmental Lead Exposure ◽  
Lead Poisoning Prevention ◽  
Poisoning Prevention

scholarly journals Study protocol to examine the relationship between environmental exposure to lead and blood lead levels among children from day-care centres in Ekurhuleni Metropolitan Municipality

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e036687
Author(s):  
Mbalenhle Desiree Cindi ◽  
Thokozani Patrick Mbonane ◽  
Nisha Naicker
Keyword(s):  
Risk Factors ◽  
Lead Exposure ◽  
Day Care ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Scientific Conference ◽  
Environmental Lead ◽  
Lead Levels ◽  
Day Care Centres ◽  
Environmental Lead Exposure

IntroductionLead exposure is toxic to all humans and is very harmful to young children, especially 5-year-olds. Elevated blood lead levels (BLLs) in children have been associated with their daily surrounding environment. This protocol seeks to evaluate the association between environmental lead exposure and BLLs among children in day-care centres, including household and other risk factors.Methods and analysisTo achieve the objectives of the study, we adopted a cross-sectional analytical design. A portable X-ray fluorescence analyser was used for environmental sampling, and BLLs were determined using the LeadCare II machine among preschool children. Household and other risk factors were assessed using a questionnaire. Random sampling was employed to select day-care centres in the municipality and children in each day-care centre. Data will be analysed using SPSS V. 26.Ethics and disseminationEthical approval and permission were obtained prior to commencement of the study. The researcher intends to publish the results in peer-reviewed journals and also to present a paper at a scientific conference. The study will generate information on environmental lead exposure among vulnerable children (2–5 years), and it will promote public health action to prevent long-term exposure in day-care centres.

Some Studies of Maternal and Infant Lead Exposure in Glasgow

1982 ◽  
Vol 27 (2) ◽  
pp. 113-121 ◽  
Author(s):  
M. R. Moore ◽  
A. Goldberg ◽  
S. J. Pocock ◽  
A. Meredith ◽  
I. M. Stewart ◽  
...  
Keyword(s):  
Social Class ◽  
Breast Milk ◽  
Lead Exposure ◽  
Lead Concentration ◽  
Blood Lead ◽  
Maternal Blood ◽  
Blood Lead Concentration ◽  
Annual Fluctuation ◽  
Environmental Lead ◽  
Environmental Lead Exposure

In two studies in the city of Glasgow, 236 mothers and their newly born infants and 117 mothers and their 6-weeks old children's environmental lead exposure were examined. In both studies blood lead concentrations were found to correlate significantly with the cube root of the domestic water lead concentrations. In the first study, multiple regression analyses of maternal blood lead and cord blood lead concentrations on other variables showed a significant negative correlation with gestational age. It was also noted that there was an annual fluctuation in maternal blood lead concentration with highest values in the autumn. In the second study, similar relationships were found. Although there was no association between blood lead and sex, age, place of birth or feeding method, as in the previous study, a significant association between social class and blood lead was found. This could be explained on the basis of the significant correlation between water lead and social class. In those mothers who breast fed, breast milk lead concentrations were found to correlate significantly with blood lead concentrations where breast milk lead was around one tenth of blood lead concentration. These studies emphasise the importance of water lead in the economy of environmental lead exposure to mothers and their unborn and newly born infants.

Environmental Lead Exposure Among Children in Chengdu, China: Blood Lead Levels and Major Sources

2009 ◽  
Vol 84 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Yong-mei Jiang ◽  
Hua Shi ◽  
Jia-yuan Li ◽  
Chuan Shen ◽  
Jin-hao Liu ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels ◽  
Environmental Lead Exposure
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