The Influence of Insulin Dependent Diabetes Mellitus on Dental Caries and Salivary Flow

Objective. To assess whether or not there was any change in the dental caries and rate of salivary flow of patients with Insulin Dependent Diabetes Mellitus (IDDM) and the contribution of salivary flow to caries risk in IDDM.Setting. Department of Endocrinology, MS Ramaiah Hospital, Bangalore, India.Design. A comparative cross-sectional descriptive type.Materials and Methods. The sample consisted of two groups: 140 diabetic group (mean age 14.8 yr) and 140 nondiabetic group (mean age 13.7 yr). Dental caries by dmf(t) and dmf(s) indices for primary dentition and DMF(T) and DMF(S) indices was used in permanent dentition to assess the dental caries experience. Both stimulated and unstimulated salivary flow rate were assessed after collection of saliva.Results. In diabetic group 76% had carious lesion and in nondiabetic group 85.3% had carious lesion. Diabetics have lower mean DMFT, DMFS, dmft, and dmfs compared to the nondiabetic group. Diminished unstimulated and stimulated salivary flow rate in diabetic than nondiabetic group.Conclusions. The findings obtained conclude that even though there was reduced salivary flow rate in diabetic group the caries prevalence was low.

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Dental caries in diabetes mellitus: role of salivary flow rate and minerals

Journal of Diabetes and its Complications ◽

10.1016/j.jdiacomp.2010.07.001 ◽

2011 ◽

Vol 25 (3) ◽

pp. 183-186 ◽

Cited By ~ 34

Author(s):

Muhammad Jawed ◽

Syed M. Shahid ◽

Shah A. Qader ◽

Abid Azhar

Keyword(s):

Diabetes Mellitus ◽

Dental Caries ◽

Flow Rate ◽

Salivary Flow ◽

Salivary Flow Rate

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Adapting Insulin Dependent Diabetes Mellitus as an optimist: Is optimism always positive?

PsycEXTRA Dataset ◽

10.1037/e536922011-127 ◽

1998 ◽

Author(s):

M. Fournier ◽

D. T. D. de Ridder

Keyword(s):

Diabetes Mellitus ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Insulin Dependent

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Insulin-Dependent Diabetes Mellitus

PsycEXTRA Dataset ◽

10.1037/e554912011-007 ◽

1993 ◽

Author(s):

Alan M. Delamater

Keyword(s):

Diabetes Mellitus ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Insulin Dependent

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Atorvastatin but Not Improves Endothelial Function in Young Subjects With Insulin Dependent Diabetes Mellitus

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84479-8 ◽

1998 ◽

Vol 31 (2) ◽

pp. 178A

Author(s):

M Mullen

Keyword(s):

Diabetes Mellitus ◽

Endothelial Function ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Insulin Dependent ◽

Young Subjects

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Elevated Circulating P-Selectin in Insulin Dependent Diabetes Mellitus

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650578 ◽

1996 ◽

Vol 76 (03) ◽

pp. 328-332 ◽

Cited By ~ 66

Author(s):

Bernd Jilma ◽

Peter Fasching ◽

Christine Ruthner ◽

Anna Rumplmayr ◽

Sabine Ruzicka ◽

...

Keyword(s):

Diabetes Mellitus ◽

Plasma Levels ◽

Plasma Concentrations ◽

Insulin Dependent Diabetes Mellitus ◽

Interquartile Range ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Intergroup Comparison ◽

Median Plasma ◽

Insulin Dependent

SummaryBased on findings that showed increased P-selectin expression on platelets and on choroidal microvessels of patients with insulin dependent diabetes mellitus (IDDM), we hypothesized that also plasma concentrations of circulating (c)P-selectin would be increased in these patients.The aim of this study was to compare the plasma levels of cP-selec-tin between non-smoking patients with IDDM, treated with an intensified insulin therapy, and healthy controls. The study design was prospective, cross-sectional and analyst-blinded. Subjects were matched individually for sex, age and body mass index. Plasma levels of cP-selectin and of von Willebrand antigen (vWF-Ag) were determined by enzyme linked immunoassays.Forty-two pairs were available for intergroup comparison. Median plasma concentrations of cP-selectin in patients with IDDM (285 ng/ml; interquartile range: 233-372) were on average 21% higher than those of controls (236 ng/ml; interquartile range: 175-296; p = 0.004). Also, median plasma levels of vWF-Ag were 10% higher in patients (96 U/dl; interquartile range: 82-127) than controls (87 U/dl; interquartile range: 70-104; p = 0.025). There was no correlation between plasma concentrations of cP-selectin and vWF-Ag levels in either group (p ώ0.05).In conclusion, our results of increased cP-selectin levels are in line with increased P-selectin expression on platelets and on choroidal microvessels found in patients with IDDM. In view of the currently developed small molecule inhibitors of cell adhesion molecules, these independent observations together may provide a sound rationale to select P-selectin as a target for treating or preventing IDDM-associated micro- or macrovascular complications.

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