scholarly journals Structured Self-Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Abas Kokab ◽  
Kevan Wylie ◽  
Patricia Allen ◽  
Abhijeeth Shetty ◽  
Debbie Davies-South
Keyword(s):  
Erectile Dysfunction ◽  
Vitamin E ◽  
Adverse Reactions ◽  
Significant Proportion ◽  
Peyronie’S Disease ◽  
Response To Treatment ◽  
Before And After ◽  
Penile Deviation ◽  
Stable Plaque ◽  
Peyronie's Disease

Introduction. New therapies evolve for the treatment of Peyronie's disease (PD) including the application of dexamethasone and verapamil using Electro Motive Drug Administration (EMDA).Patients and Methods. Patients with PD were routinely offered Potaba, Vitamin E, tamoxifen or colchicine for 6 to 18 months and for those with no improvement, 18 applications of dexamethasone and verapamil using EMDA occurred over a 6 week period. All 30 patients receiving EMDA therapy completed a questionnaire before and after treatment. The data was collected from December 2004 to November 2009 and analysed to evaluate the effectiveness of the treatment.Results. Median age of patients was 59 (range 39–71). Curvature was the most common presenting complaint (73.3%) followed by pain (23.3%), erectile dysfunction (13.3%), and lump (13.3%). 24/30 (80%) reported an improvement in symptoms after EMDA. 16 of the responders (66.7%) had a stable plaque for at least 6 months. The patients who complained of shortening of the penis (P=0.003) or lowered sexual desire (P=0.024) expressed subsequently significant response to treatment. There was statistically significant (P=0.019) improvement of penile deviation reported by responding men.Conclusion. A significant proportion of patients who received EMDA reported decreased curvature following iontophoresis. No serious adverse reactions developed.

scholarly journals Penile prosthesis implant with bi-triangular excision and graft for surgical therapy of Peyronie’s disease: A case report

2016 ◽  
Vol 87 (4) ◽  
pp. 337
Author(s):  
Alexandre De Freitas Miranda ◽  
Bruno Lopes Cançado Machado
Keyword(s):  
Erectile Dysfunction ◽  
Penile Prosthesis ◽  
Peyronie’S Disease ◽  
Penile Curvature ◽  
Prosthesis Implantation ◽  
Inflatable Penile Prosthesis ◽  
High Satisfaction ◽  
Patient Reported ◽  
Penile Deviation ◽  
Peyronie's Disease

We present a case of a 65-year-old man, who presented with moderate erectile dysfunction and a dorsal penile deviation of 60° caused by Peyronie’s disease. The patient underwent bi-triangularshaped plaque excision, followed by grafting and implantation of inflatable penile prosthesis. Complete penile straightening, without mechanical or geometric abnormalities, was achieved using bi-triangular excision and grafting. Postoperatively, the patient reported high satisfaction with the results and could perform sexual intercourse naturally. This novel technique corrects any degree of penile curvature, permits malleable and semi-rigid penile prosthesis implantation, avoids penile length loss, and eliminates additional incisions. To our knowledge, this case is the first in the literature in which the bi-triangular technique was successfully used for penile prosthesis implantation secondary to Peyronie’s disease. This new technique appears to be a good solution to correct penile curvature during penile prosthesis implantation for the treatment of Peyronie’s disease associated with erectile dysfunction.

IMPROVING THE EFFECTIVENESS OF CONSERVATIVE TREATMENT OF ERECTILE DYSFUNCTION IN PATIENTS WITH PEYRONIE'S DISEASE USING THE "BTL 6000" SHOCK WAVE THERAPY APPARATUS AND THE "TIVORTIN" DRUG

Vestnik ◽  
2021 ◽  
pp. 380-386
Author(s):  
М.К. Алчинбаев ◽  
А.Ж. Суранчиев ◽  
Д.И. Сенгирбаев ◽  
А.Д. Нисанбаев ◽  
Г.А. Испосунова
Keyword(s):  
Shock Wave ◽  
Erectile Dysfunction ◽  
Morphological Structure ◽  
Blood Flow Rate ◽  
No Synthase ◽  
Peyronie’S Disease ◽  
Shock Wave Therapy ◽  
Altered Protein ◽  
Therapy Apparatus ◽  
Peyronie's Disease

Исследовалось эффективность комплексной терапии эректильной дисфункции у пациентов с болезнью Пейрони, с применением препарата "Тивортин", который является субстратом для NO-синтазы - фермента, который катализирует синтез оксида азота в эндотелиоцитах, тем самым вызывая стабилизацию скорости кровотока в артериях полового члена, а также способствует восстановлению морфологической структуры, измененной белочной оболочки; и аппарата ударно-волновой терапий "БТЛ 6000", предназначенный для дезинтеграции бляшек в стадии кальцификации, которая купирует болевые ощущения в 91% случаев и уменьшает деформацию полового члена в 31% случаев, путем ударно-волновой терапии, и улучшения микроциркуляции в кавернозных телах полового члена, тем самым повышает эффективность лечения эректильной дисфункции у больных с болезнью Пейрони. The effectiveness of complex therapy of erectile dysfunction in patients with Peyronie's disease was studied with the use of the drug "Tivortin", which is a substrate for NO-synthase, an enzyme that catalyzes the synthesis of nitric oxide in endotheliocytes, thereby causing stabilization of the blood flow rate in the arteries of the penis, and also contributes to the restoration of the morphological structure, the altered protein envelope; and the shock wave therapy apparatus "BTL 6000", designed for the disintegration of plaques in the calcification stage, which relieves pain in 91% of cases and reduces the deformation of the penis in 31% of cases, by shock wave therapy, and improves microcirculation in the cavernous bodies of the penis, thereby increasing the effectiveness of treatment of erectile dysfunction in patients with Peyronie's disease.

scholarly journals Corporoplasty in Peyronie’s Disease: a Literature Review

2021 ◽  
Vol 11 (3) ◽  
pp. 209-219
Author(s):  
V. N. Pavlov ◽  
A. A. Bakirov ◽  
R. A. Kazikhinurov ◽  
A. A. Kazikhinurov ◽  
M. A. Agaverdiev ◽  
...  
Keyword(s):  
Treatment Options ◽  
Penile Prosthesis ◽  
Peyronie’S Disease ◽  
Usual Practice ◽  
Current Trends ◽  
Penile Deviation ◽  
Pros And Cons ◽  
Peyronie's Disease ◽  
Correction Surgery ◽  
Review Current

Corporoplasty is urological correction surgery for penile deviation that causes copulatory dysfunction or aesthetic discomfort. Penile deviation can be congenital or acquired (Peyronie’s disease, penile fracture). Congenital penile deviation is relatively rare and manifests in the curvature of erect penis ventrally and/or laterally, in most cases. According to many studies, patients with curvatures of 30° or more eventually seek surgical treatment. Congenital curvature may be mistaken for Peyronie’s disease for similar manifestations that, however, differ in aetiology and pathophysiology. Excisional, incisional corporoplasty or plication are commonly engaged to treat congenital curvatures, in various techniques and modifications. Augmentation transplantation (grafting) and penile prosthesis implantation with variant deviation treatment options are the usual practice in Peyronie’s disease. Unequivocal judgment of pros and cons in any particular technique is nevertheless implausible to make. This article aims to review current trends, protocols and their relative advantages in corporoplasty.

scholarly journals Topical Vitamin E Acetate for the Treatment of Cheilitis: A Multicentre Experience

2003 ◽  
Vol 1 (3) ◽  
pp. 125-128 ◽  
Author(s):  
N. Cassano ◽  
M. De Benedittis ◽  
M. Petruzzi ◽  
M. Carbonara ◽  
C. Agnusdei ◽  
...  
Keyword(s):  
Vitamin E ◽  
Adverse Reactions ◽  
Contact Allergy ◽  
Response To Treatment ◽  
Vitamin E Acetate ◽  
Frequent Form ◽  
Oral Isotretinoin ◽  
Safe Approach ◽  
Symptoms And Signs ◽  
Overall Effectiveness

Treatment of cheilitis is usually difficult and often disappointing. We evaluated the effects of a topical preparation containing vitamin E acetate (VEA® lipogel) in 254 patients (mean age, 29.5) with cheilitis of various nature and etiology, involving the vermilion region and/or the perioral skin. The most frequent form of cheilitis was that induced by oral isotretinoin; other forms were irritant contact dermatitis, atopic cheilitis, and contact allergy. Patients were instructed to apply VEA® lipogel daily; the number of daily applications was modulated on the basis of the severity of symptoms (two or three times a day in the majority of cases). After 4 weeks of treatment, clinical examination showed that the severity of symptoms and signs significantly improved (P<0.001). The response to treatment was reported as particularly rapid by 32% of patients. Patient's assessment of overall effectiveness and acceptability was positive in the majority of cases. Treatment was well tolerated; local adverse reactions were observed in 2.75% of patients and were mostly transient and mild. Our experience suggests that VEA® lipogel is an effective and safe approach to cheilitis. The safety of this preparation is also due to the presence of only a few excipients and the absence of fragrances, preservatives and colouring agents.

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