scholarly journals Assessment of Disease Activity in Small Bowel Crohn’s Disease: Comparison between Endoscopy and Magnetic Resonance Enterography Using MRIA and Modified MRIA Score

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Arnaldo Scardapane ◽  
Annalisa Ambrosi ◽  
Emanuela Salinaro ◽  
Maria Elisabetta Mancini ◽  
Mariabeatrice Principi ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Magnetic Resonance Enterography ◽  
Wall Thickening ◽  
Relative Contrast ◽  
Modified Formula ◽  
Assessment Of Disease Activity

Objectives. To retrospectively compare the results of the MRIA (magnetic resonance index of activity) with a modified MRIA (mMRIA), which was calculated excluding from MRIA formula the data of relative contrast enhancement (RCE).Materials and Methods. MR-E and corresponding endoscopic records of 100 patients were reviewed. MRIA, mMRIA, and SES endoscopic index were calculated for all the patients. Namely, MRIA was calculated as follows: (1.5 × wall thickening + 0.02 × RCE + 5 × intramural edema + 10 × ulcers), while mMRIA was calculated with the modified formula (1.5 × wall thickening + 5 × intramural edema + 10 × ulcers).Results. Mean MRIA and mMRIA values were 19.3 and 17.68, respectivelyp<0.0001. A significant correlationp<0.0001was observed between MRIA and mMRIA scores and between both MR indexes and SESp<0.0001.Conclusions. mMRIA was comparable to MRIA in the evaluation of disease activity in Crohn’s disease.

Tu1213 Reproducibility of Magnetic Resonance Enterography Assessment of Disease Activity in Crohn's Disease Using Central Readers

2015 ◽  
Vol 148 (4) ◽  
pp. S-824 ◽  
Author(s):  
Ingrid Ordás ◽  
Jordi Rimola ◽  
Guangyong Zou ◽  
Cynthia Santillan ◽  
Karin Horsthuis ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Magnetic Resonance Enterography ◽  
Assessment Of Disease Activity

971 Impact of Magnetic Resonance Enterography in the Management of Small Bowel Crohn's Disease

2012 ◽  
Vol 142 (5) ◽  
pp. S-169
Author(s):  
Danny Cheriyan ◽  
Eoin Slattery ◽  
Shaunagh McDermott ◽  
Aoife Kilcoyne ◽  
Denise Keegan ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Magnetic Resonance Enterography

scholarly journals Panenteric capsule endoscopy versus ileocolonoscopy plus magnetic resonance enterography in Crohn’s disease: a multicentre, prospective study

2020 ◽  
Vol 7 (1) ◽  
pp. e000365 ◽  
Author(s):  
David Henry Bruining ◽  
Salvatore Oliva ◽  
Mark R Fleisher ◽  
Monika Fischer ◽  
Joel G Fletcher
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Capsule Endoscopy ◽  
Terminal Ileum ◽  
Imaging Modality ◽  
Disease Diagnosis ◽  
Magnetic Resonance Enterography ◽  
Proximal Small Bowel

IntroductionCrohn’s disease diagnosis and monitoring remains a great clinical challenge and often requires multiple testing modalities. Assessing Crohn’s disease activity in the entire gastrointestinal (GI) tract using a panenteric capsule endoscopy (CE) system could be used as an alternative to colonoscopy and cross-sectional imaging. This study assessed the accuracy and safety of panenteric CE in Crohn’s disease as compared with ileocolonoscopy (IC) and/or magnetic resonance enterography (MRE).MethodsA prospective, multicentre study was performed in subjects with established Crohn’s disease. Individuals with proven small bowel patency underwent a standardised bowel preparation, followed by CE ingestion and IC either the same or following day. MRE, IC, and CE interpretations were performed by blinded central readers using validated scoring systems. The primary endpoint was the overall sensitivity of CE vs MRE and/or IC in Crohn’s disease subjects.ResultsStudy enrolment included 158 subjects from 21 sites in the USA, Austria, and Israel. Of those, 99 were included in the analysis. Imaging modality scores indicated none to mild inflammation in the proximal small bowel and colon, but discrepant levels of inflammation in the terminal ileum. Overall sensitivity for active enteric inflammation (CE vs MRE and/or IC) was 94% vs 100% (p=0.125) and specificity was 74% vs 22% (p=0.001). Sensitivity of CE was superior to MRE for enteric inflammation in the proximal small bowel (97% vs 71%, p=0.021), and similar to MRE and/or IC in the terminal ileum and colon (p=0.500–0.625). There were seven serious adverse advents of which three were related to the CE device.ConclusionPanenteric CE is a reliable tool for assessing Crohn’s disease mucosal activity and extent compared with more invasive methods. This study demonstrates high performance of the panenteric CE as compared to MRE and/or IC without the need for multiple tests in non-stricturing Crohn’s disease.Trial registration numberClinicalTrials.gov NCT03241368

Magnetic resonance enterography in Crohn’s disease: new simple proposal to assess disease activity

2016 ◽  
Vol 40 (3) ◽  
pp. 492-497 ◽  
Author(s):  
Elsa Iannicelli ◽  
Isabella Martini ◽  
Claudia Fantini ◽  
Claudio Papi ◽  
Paola Gigante ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Magnetic Resonance Enterography
Sign in / Sign up

Export Citation Format

Share Document