P201. Reproducibility of magnetic resonance enterography assessment of disease activity in Crohn's Disease using central readers

Objectives. To retrospectively compare the results of the MRIA (magnetic resonance index of activity) with a modified MRIA (mMRIA), which was calculated excluding from MRIA formula the data of relative contrast enhancement (RCE).Materials and Methods. MR-E and corresponding endoscopic records of 100 patients were reviewed. MRIA, mMRIA, and SES endoscopic index were calculated for all the patients. Namely, MRIA was calculated as follows: (1.5 × wall thickening + 0.02 × RCE + 5 × intramural edema + 10 × ulcers), while mMRIA was calculated with the modified formula (1.5 × wall thickening + 5 × intramural edema + 10 × ulcers).Results. Mean MRIA and mMRIA values were 19.3 and 17.68, respectivelyp<0.0001. A significant correlationp<0.0001was observed between MRIA and mMRIA scores and between both MR indexes and SESp<0.0001.Conclusions. mMRIA was comparable to MRIA in the evaluation of disease activity in Crohn’s disease.

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Magnetic resonance enterography in Crohn’s disease: new simple proposal to assess disease activity

Clinical Imaging ◽

10.1016/j.clinimag.2015.11.009 ◽

2016 ◽

Vol 40 (3) ◽

pp. 492-497 ◽

Cited By ~ 3

Author(s):

Elsa Iannicelli ◽

Isabella Martini ◽

Claudia Fantini ◽

Claudio Papi ◽

Paola Gigante ◽

...

Keyword(s):

Crohn’S Disease ◽

Magnetic Resonance ◽

Crohn's Disease ◽

Disease Activity ◽

Magnetic Resonance Enterography

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Su1294 Computed Tomography Enterography Versus Magnetic Resonance Enterography for Assessment of Disease Activity and Complications in Small Bowel Crohn's Disease: A Meta-Analysis of Head-to-Head Comparative Studies

Gastroenterology ◽

10.1016/s0016-5085(14)61540-7 ◽

2014 ◽

Vol 146 (5) ◽

pp. S-428-S-429

Author(s):

Yun Qiu ◽

Ren Mao ◽

Bai-li Chen ◽

Yao He ◽

Zhirong Zeng ◽

...

Keyword(s):

Computed Tomography ◽

Crohn’S Disease ◽

Magnetic Resonance ◽

Small Bowel ◽

Disease Activity ◽

Comparative Studies ◽

Meta Analysis ◽

Magnetic Resonance Enterography ◽

Computed Tomography Enterography ◽

Assessment Of Disease Activity

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T1279 Magnetic Resonance Enterography in the Assessment of the Disease Activity in Crohn's Disease – A Retrospective Study

Gastroenterology ◽

10.1016/s0016-5085(10)62433-x ◽

2010 ◽

Vol 138 (5) ◽

pp. S-527

Author(s):

Carmen S. Horjus ◽

Rutger Bruijnen ◽

Dirk J. De Jong ◽

Martijn G. van Oijen ◽

Marcel J. Groenen ◽

...

Keyword(s):

Crohn’S Disease ◽

Retrospective Study ◽

Magnetic Resonance ◽

Crohn's Disease ◽

Disease Activity ◽

Magnetic Resonance Enterography

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Magnetic resonance enterography, colonoscopy, and fecal calprotectin correlate in colonic Crohn’s disease

BMC Gastroenterology ◽

10.1186/s12876-019-1125-7 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Alexander S. Somwaru ◽

Vikesh Khanijow ◽

Venkat S. Katabathina

Keyword(s):

Crohn’S Disease ◽

Magnetic Resonance ◽

Crohn's Disease ◽

Disease Activity ◽

Activity Index ◽

Disease Activity Index ◽

Clinical Results ◽

Fecal Calprotectin ◽

Magnetic Resonance Enterography ◽

Crohn’S Disease Activity

Abstract Background Fecal calprotectin (FCP), magnetic resonance enterography (MRE), and colonoscopy are complementary biometric tests that are used to assess patients with Crohn’s Disease (CD). While prior studies have evaluated the association between combinations of these tests, no study has established a correlation between all three: FCP, MRE, and colonoscopy. We prospectively investigated if there is correlation between these three tests, which may result in improved clinical outcomes that can then be used to streamline patient monitoring and treatment modification. Methods One hundred fifty-six patients with colonic CD were prospectively examined between March 2017 and December 2018. FCP levels, MRE, and colonoscopy were assessed in parallel on all 156 patients. Clinical CD activity was measured with the Crohn’s Disease Activity Index (CDAI). CD activity with FCP was measured with a quantitative immunoassay. CD activity on MRE was measured with the Magnetic Resonance Index of Activity (MaRIA). CD activity on colonoscopy was measured with the Crohn’s Disease Endoscopic Index of Severity (CDEIS). Results One hundred twelve patients (72%) had active disease (Crohn’s Disease Activity Index > 150) and 44 patients (28%) were in clinical remission disease (Crohn’s Disease Activity Index < 150). FCP levels, MaRIA, and CDEIS are highly correlated with positive and significant Pearson and Spearman coefficients, respectively (P < 0.0001), in univariate analyses. Regression analysis (multivariate analyses) demonstrates significant, positive correlation between FCP and MaRIA (r = 1.07, P < 0.0001) and between FCP and CDEIS (r = 0.71, P = 0.03), and between. MaRIA and CDEIS (r = 0.63, P = 0.01). Conclusions FCP levels significantly correlate with the degree of active inflammation in patients with colonic Crohn’s Disease. Improved clinical results may be achieved by using a biometric strategy that incorporates FCP, colonoscopy, and MRE together. This strategy may in-turn be used in the future to streamline monitoring disease activity and adjustment of therapy to improve long term patient outcomes.

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Assessment of pediatric Crohn’s disease activity: validation of the magnetic resonance enterography global score (MEGS) against endoscopic activity score (SES-CD)

Abdominal Radiology ◽

10.1007/s00261-020-02590-8 ◽

2020 ◽

Vol 45 (11) ◽

pp. 3653-3661

Author(s):

Xianying Zheng ◽

Meina Li ◽

Yinchen Wu ◽

Xuehua Lin ◽

Zhongshuai Zhang ◽

...

Keyword(s):

Crohn’S Disease ◽

Magnetic Resonance ◽

Crohn's Disease ◽

Disease Activity ◽

Magnetic Resonance Enterography ◽

Activity Score ◽

Global Score ◽

Crohn’S Disease Activity

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Magnetic Resonance Enterography, Colonoscopy, and Fecal Calprotectin correlate in colonic Crohn’s Disease

10.21203/rs.2.13286/v1 ◽

2019 ◽

Author(s):

Alexander Stephen Somwaru ◽

Vikesh Khanijow ◽

Venkat Katabathina

Keyword(s):

Crohn’S Disease ◽

Magnetic Resonance ◽

Crohn's Disease ◽

Disease Activity ◽

Activity Index ◽

Disease Activity Index ◽

Clinical Results ◽

Fecal Calprotectin ◽

Magnetic Resonance Enterography ◽

Crohn’S Disease Activity

Abstract Background Fecal calprotectin (FCP), magnetic resonance enterography (MRE), and colonoscopy are complementary biometric tests that are used to assess patients with Crohn’s Disease (CD). While prior studies have evaluated the association between combinations of two of these tests or surgical specimens, no study has established a correlation between all three: FCP, MRE, and colonoscopy. We investigated if the correlation between these three tests may result in improved clinical outcomes that can then be used to streamline patient monitoring and treatment modification. Methods 156 patients with colonic CD were examined between March 2017 and December 2018. FCP levels, MRE, and colonoscopy were assessed in parallel on all 156 patients. Clinical CD activity was measured with the Crohn’s Disease Activity Index (CDAI). CD activity with FCP was measured with a quantitative immunoassay. CD activity on MRE was measured with the Magnetic Resonance Index of Activity (MaRIA). CD activity on colonoscopy was measured with the Crohn’s Disease Endoscopic Index of Severity (CDEIS). Results 112 patients (72%) had active disease (Crohn’s Disease Activity Index > 150) and 44 patients (28%) were in clinical remission disease (Crohn’s Disease Activity Index < 150). FCP levels, MaRIA, and CDEIS are highly correlated with positive and significant Pearson and Spearman coefficients, respectively (P < 0.0001), in univariate analyses. Regression analysis (multivariate analyses) demonstrates significant, positive correlation between FCP and MaRIA (r = 1.07, P < 0.0001) and between FCP and CDEIS (r = 0.71, P = 0.03), and between MaRIA and CDEIS (r = 0.63, P = 0.01). Conclusions FCP levels significantly correlate with the degree of active inflammation in patients with colonic Crohn’s Disease. Improved clinical results may be achieved by using a biometric strategy that incorporates FCP, colonoscopy, and MRE together. This strategy may in-turn be used in the future to streamline monitoring disease activity and adjustment of therapy to improve long term patient outcomes.

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