scholarly journals Anesthesia Related Toxic Effects on In Vitro Fertilization Outcome: Burden of Proof

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Paraskevi Matsota ◽  
Eva Kaminioti ◽  
Georgia Kostopanagiotou
Keyword(s):  
In Vitro Fertilization ◽  
Burden Of Proof ◽  
Oocyte Retrieval ◽  
Toxic Effects ◽  
Published Data ◽  
Anesthetic Techniques ◽  
Safe Alternative ◽  
Vitro Fertilization ◽  
Anesthetic Agents

Management of pain and anxiety during oocyte retrieval makes anesthesia an important part of the in vitro fertilization (IVF) procedures. There are many studies investigating the influence of anesthesia on IVF success. This review article provides an overview of published data regarding the potential toxic effects of different anesthetic techniques (Loco-regional, general anesthesia (GA), and monitored anesthesia care (MAC)), different anesthetic agents, and alternative medicine approach (principally acupuncture) on the IVF outcome. From our analysis, evidence of serious toxicity in humans is not well established. Trials regarding different anesthetic techniques ended up without clear conclusions. Studies about GA came up with conflicting results. A few trials relate GA with lower pregnancy rates, although some others failed to prove this conclusion. Furthermore, detectable amounts of some anesthetic agents are measurable in the follicular fluid but these findings are not strongly associated with toxicity. MAC and Loco-regional anesthesia appear as safe alternative choices and there is evidence of improved outcome. Whereas acupuncture may provide assistance increasing IVF success according to some trials, some others could not obtain these effects. Questions about the appropriate time of application and the underlying mechanism of action are not answered yet, so further investigation should be done.

scholarly journals The effect of Propofol versus Dexmedetomidine as anesthetic agents for oocyte pick-up on in vitro fertilization (IVF) outcomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Özcan Budak ◽  
Mehmet Sühha Bostancı ◽  
AyçaTaş Tuna ◽  
Veysel Toprak ◽  
Hüseyin Çakiroğlu ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Oocyte Retrieval ◽  
Vitro Fertilization ◽  
Ivf Outcomes ◽  
Anesthetic Agents ◽  
Significant Difference ◽  
Embryo Number ◽  
Group 2

AbstractThis study aimed to evaluate the effects of propofol and dexmedetomidine over different timescales on the IVF outcomes for transvaginal oocyte retrieval (TVOR). Twenty-four rats included in the study were divided into two main groups and three subgroups were subjected to the ovulation induction process. Group 1 was administered propofol (100 mg/kg i.v.) and group 2 were administered dexmedetomidine (25 µg/kg i.p.) The oviduct collection procedure was completed within 15 min for subgroup Pro15min, Dex15min (n = 4), within 16 to 30 min for subgroup Pro30min, Dex30min (n = 4) and within 31 to 60 min for subgroup Pro60min, Dex60min (n = 4) after euthanasia. The total number of oocytes was counted. After in vitro fertilization, the number and quality of embryos were evaluated. The number of pups born were evaluated after embryo transfer. The embryo number, quality and pup count decreased as the administration time for propofol increased (p < 0.05). No statistically significant difference was found between the dexmedetomidine subgroups for embryo number, quality and pup count(p > 0.05). As the exposure time to propofol increased, the number and quality of embryos obtained, and the pup count, decreased. The use of dexmedetomidine had no negative impacts on the number of embryos, their quality or the number of pups.

Predictive Model for Live Birth at 12 Months After Starting In-Vitro Fertilization Treatment

MedPharmRes ◽  
2018 ◽  
Vol 2 (2) ◽  
pp. 5-20
Author(s):  
Vu Ho ◽  
Toan Pham ◽  
Tuong Ho ◽  
Lan Vuong
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Cox Regression ◽  
Financial Burden ◽  
Oocyte Retrieval ◽  
Operating Characteristics ◽  
Vitro Fertilization ◽  
Cox Regression Analysis ◽  
Significant Difference

IVF carries a considerable physical, emotional and financial burden. Therefore, it would be useful to be able to predict the likelihood of success for each couple. The aim of this retrospective cohort study was to develop a prediction model to estimate the probability of a live birth at 12 months after one completed IVF cycle (all fresh and frozen embryo transfers from the same oocyte retrieval). We analyzed data collected from 2600 women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) at a single center in Vietnam between April 2014 and December 2015. All patients received gonadotropin-releasing hormone (GnRH) antagonist stimulation, followed by fresh and/or frozen embryo transfer (FET) on Day 3. Using Cox regression analysis, five predictive factors were identified: female age, total dose of recombinant follicle stimulating hormone used, type of trigger, fresh or FET during the first transfer, and number of subsequent FET after the first transfer. The area under the receiver operating characteristics curve for the final model was 0.63 (95% confidence interval [CI] 0.60‒0.65) and 0.60 (95% CI 0.57‒0.63) for the validation cohort. There was no significant difference between the predicted and observed probabilities of live birth (Hosmer-Lemeshow test, p > 0.05). The model developed had similar discrimination to existing models and could be implemented in clinical practice.

scholarly journals Effects of Hydrosalpinx on Endometrial Implantation Failures: Evaluating Salpingectomy in Women Undergoing in vitro fertilization

2021 ◽  
Author(s):  
Antonio Palagiano ◽  
Mauro Cozzolino ◽  
Filippo Maria Ubaldi ◽  
Chiara Palagiano ◽  
Maria Elisabetta Coccia
Keyword(s):  
In Vitro Fertilization ◽  
Oocyte Retrieval ◽  
Ovarian Response ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Endometrial Receptivity ◽  
Vitro Fertilization ◽  
Ovid Medline ◽  
Ultrasonographic Guidance

AbstractHydrosalpinx is a disease characterized by the obstruction of the salpinx, with progressive accumulation in the shape of a fluid-filled sac at the distal part of the tuba uterina, and closed to the ovary. Women with hydrosalpinges have lower implantation and pregnancy rates due to a combination of mechanical and chemical factors thought to disrupt the endometrial environment. Evidence suggests that the presence of hydrosalpinx reduces the rate of pregnancy with assisted reproductive technology. The main aim of the present is review to make an overview of the possible effects of hydrosalpinx on in vitro fertilization (IVF). We conducted a literature search on the PubMed, Ovid MEDLINE, and Google Scholar data bases regarding hydrosalpinx and IVF outcomes. Hydrosalpinx probably has a direct toxic effect on sperm motility and on the embryos. In addition, the increasing liquid inside the salpinges could alter the mechanisms of endometrial receptivity. The window of endometrial receptivity is essential in the implantation of blastocysts, and it triggers multiple reactions arising from the endometrium as well as the blastocysts. Hydrosalpinx could influence the expression of homeobox A10 (HOXA10) gene, which plays an essential role in directing embryonic development and implantation. Salpingectomy restores the endometrial expression of HOXA10; therefore, it may be one mechanism by which tubal removal could result in improved implantation rates in IVF. In addition, salpingectomy does not affect the ovarian response, nor reduces the antral follicle count. Further studies are needed to establish the therapeutic value of fluid aspiration under ultrasonographic guidance, during or after oocyte retrieval, in terms of pregnancy rate and ongoing pregnancy.

Ureaplasma parvum peritonitis after oocyte retrieval for in vitro fertilization

2014 ◽  
Vol 172 ◽  
pp. 138-139 ◽  
Author(s):  
C. Bébéar ◽  
V. Grouthier ◽  
C. Hocké ◽  
C. Jimenez ◽  
A. Papaxanthos ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Oocyte Retrieval ◽  
Vitro Fertilization ◽  
Ureaplasma Parvum

Programmed ovulation induction and oocyte retrieval for in vitro fertilization

1988 ◽  
Vol 5 (3) ◽  
pp. 153-157 ◽  
Author(s):  
J. Salat-Baroux ◽  
J. M. Antoine ◽  
S. Alvarez ◽  
D. Cornet ◽  
Ch. Tibi ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Ovulation Induction ◽  
Oocyte Retrieval ◽  
Vitro Fertilization

Anesthesia for In Vitro Fertilization

2011 ◽  
pp. 198-205
Author(s):  
Patricia M. Sequeira
Keyword(s):  
In Vitro Fertilization ◽  
Transvaginal Ultrasound ◽  
Oocyte Retrieval ◽  
Laboratory Setting ◽  
Vitro Fertilization ◽  
Vaginal Ultrasound ◽  
Broad Term ◽  
Oocyte Aspiration ◽  
Fertilized Egg

In vitro fertilization (IVF) is a broad term used to describe the process of obtaining an egg and uniting it with sperm in a laboratory setting, and subsequently placing the fertilized egg into the uterus in hopes of achieving a live birth. In terms of anesthesiology, IVF primarily means oocyte retrieval. Historically the oocytes were retrieved laparoscopically. With the introduction of the vaginal ultrasound, the method of retrieval changed to a less invasive and costly procedure. Transvaginal ultrasound-guided oocyte aspiration changed the requirements of anesthesia. In this chapter, the anesthesia for oocyte retrieval and related IVF procedures are described.

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