scholarly journals When Is Evidence Enough Evidence? A Systematic Review and Meta-Analysis of the Trabectome as a Solo Procedure in Patients with Primary Open-Angle Glaucoma

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Jeffrey T. Y. Chow ◽  
Cindy M. L. Hutnik ◽  
Karla Solo ◽  
Monali S. Malvankar-Mehta
Keyword(s):  
Systematic Review ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Glaucoma Surgery ◽  
Integrated Approach ◽  
Open Angle ◽  
Potential Safety ◽  
Mean Differences ◽  
The Many

The purpose of this systematic review and meta-analysis was to examine the availability of evidence for one of the earliest available minimally invasive glaucoma surgery (MIGS) procedures, the Trabectome. Various databases were searched up to December 20, 2016, for any published studies assessing the use of the Trabectome as a solo procedure in patients with primary open-angle glaucoma (POAG). The standardized mean differences (SMD) were calculated for the change in intraocular pressure (IOP) and number of glaucoma mediations used at 1-month, 6-month, and 12-month follow-up. After screening, three studies and one abstract with analyzable data were included. The meta-analysis showed statistically significant reductions in IOP and number of glaucoma medications used at all time points. Though the Trabectome as a solo procedure appears to lower IOP and reduces the number of glaucoma medications, more high-quality studies are required to make definitive conclusions. The difficulty of obtaining evidence may be one of the many obstacles that limit a full understanding of the potential safety and/or efficacy benefits compared to standard treatments. The time has come for a thoughtful and integrated approach with stakeholders to determine optimal access to care strategies for our patients.

scholarly journals Myocilin Polymorphisms and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e46632 ◽  
Author(s):  
Jin-Wei Cheng ◽  
Shi-Wei Cheng ◽  
Xiao-Ye Ma ◽  
Ji-Ping Cai ◽  
You Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Open Angle

scholarly journals Can dorzolamide/timolol-fixed combination effectively treat primary open-angle glaucoma? A protocol for systematic review and meta-analysis

2020 ◽  
Author(s):  
Yan-Xiu Qi ◽  
Hong-wei Liu ◽  
Xing-jie Su ◽  
Lin Han
Keyword(s):  
Systematic Review ◽  
Primary Open Angle Glaucoma ◽  
Fixed Combination ◽  
Open Angle Glaucoma ◽  
Data Extraction ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Open Angle ◽  
Efficacy And Safety ◽  
China National Knowledge Infrastructure

Abstract Background: Primary open-angle glaucoma (POAG) is a very common disorder, and it is the second leading reason that leads to blindness worldwide after cataracts. Previous studies have reported that dorzolamide/timolol-fixed combination (DTFC) can be used to treat patients with POAG. However, there are still inconsistent results. Thus, this study will systematically investigate the efficacy and safety of DTFC for the treatment of patients with POAG.Methods: A comprehensive search will be carried out in the electronic databases of Cochrane Library, MEDLINE, EMBASE, CINAHI, ACMD, China National Knowledge Infrastructure, and Wanfang Data from origin to the March 1, 2020. There are no limitations related to the language and publication status. Only randomized controlled trials that assessed the efficacy and safety of DTFC for the treatment of POAG will be included. Two researchers will independently undertake record selection, data extraction, and methodological quality assessment. Any divisions will be solved by discussion with a third researcher. We will perform statistical analysis using RevMan 5.3 softwareDiscussion: This study will summarize present evidence to identify the efficacy and safety of DTFC for the treatment of POAG through mean intraocular pressure, best corrected visual acuity, contrast sensitivity, bioelectric activity of the retina, rate of progression of glaucoma, quality of life, and adverse events. The results of this study will help to determine whether DTFC is effective and safety for the treatment of POAG.Systematic review registration: INPLASY202040120.

scholarly journals Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis

2015 ◽  
Vol 100 (1) ◽  
pp. 86-93 ◽  
Author(s):  
Venediktos V Kapetanakis ◽  
Michelle P Y Chan ◽  
Paul J Foster ◽  
Derek G Cook ◽  
Christopher G Owen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Time Trends ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Open Angle

scholarly journals The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Binghua Tang ◽  
Shengjie Li ◽  
Wenjun Cao ◽  
Xinghuai Sun
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Aqueous Humor ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Control Group ◽  
Open Angle ◽  
Exfoliation Glaucoma ◽  
Oxidative Stress Status ◽  
Mean Differences

Purpose. To systematically evaluate the associations between oxidative stress status and different types of glaucoma. Design. Systematic review and meta-analysis. Methods. We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. A random effects model was used to estimate oxidative stress status along with weighted mean differences and 95% confidence intervals (CIs). A funnel plot analysis and Egger’s test were performed to assess potential publication bias. Main outcome measures. Oxidative stress status was abnormal and different in patients with OAG (open-angle glaucoma) and EXG (exfoliation glaucoma). Results. Blood TAS (total antioxidant status) was lower in the OAG group than in the control group, with a mean difference of 0.580 mmol/L (p<0.0001, 95% CI = −0.668 to −0.492). The aqueous humor SOD (superoxide dismutase), GPX (glutathione peroxidase), and CAT (catalase) levels were higher in the OAG group than in the control group, with mean differences of 17.989 U/mL (p<0.0001, 95% CI = 14.579–21.298), 12.441 U/mL (p<0.0001, 95% CI = 10.423–14.459), and 1.229 fmol/mL (p=0.042, 95% CI = 0.043–2.414), respectively. Blood TAS was lower in the EXG group than in the control group, with a mean difference of 0.262 mmol/L (p<0.0001, 95% CI = −0.393 to −0.132). However, there were no differences in blood TOS and aqueous humor TOS between the EXG group and the control group. Conclusions. This meta-analysis indicates that OAG patients had a lower TAS in the blood and higher levels of SOD, GPX, and CAT in the aqueous humor, while EXG patients only had a decreased TAS in the blood.

Penetrance of MYOC gene mutation in primary open-angle glaucoma: A systematic review and meta-analysis

2022 ◽  
pp. 1-8
Author(s):  
Juan-Juan Xie ◽  
Guo-Wei Zhang ◽  
Hai-Yue Cui ◽  
Na Li ◽  
Xing-Xing Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gene Mutation ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Open Angle
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