scholarly journals Peripheral Ulcerative Keratitis Associated with Autoimmune Disease: Pathogenesis and Treatment

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Yan Cao ◽  
Wensong Zhang ◽  
Jie Wu ◽  
Hong Zhang ◽  
Hongyan Zhou
Keyword(s):  
Lupus Erythematosus ◽  
Microscopic Polyangiitis ◽  
Corneal Stroma ◽  
Relapsing Polychondritis ◽  
Wegener Granulomatosis ◽  
Inflammatory Damage ◽  
Peripheral Ulcerative Keratitis ◽  
Strauss Syndrome ◽  
Ulcerative Keratitis ◽  
Churg Strauss

Peripheral ulcerative keratitis (PUK) is type of crescent-shaped inflammatory damage that occurs in the limbal region of the cornea. PUK is always combined with an epithelial defect and the destruction of the peripheral corneal stroma. PUK may have a connection to systemic conditions, such as long-standing rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Wegener granulomatosis (WG), relapsing polychondritis, classic polyarteritis nodosa and its variants, microscopic polyangiitis, and Churg-Strauss syndrome. However, the most common connection is with RA, which is also the focus of this review. The pathogenesis of PUK is still unclear. It is thought that circulating immune complexes and cytokines exert an important influence on the progression of this syndrome. Treatment is applied to inhibit certain aspects of PUK pathogenesis.

Anca in Dialysis Patients: A Role for Bioincompatibility?

2000 ◽  
Vol 23 (2) ◽  
pp. 97-103 ◽  
Author(s):  
B. Andreini ◽  
V. Panichi ◽  
C. Cirami ◽  
M. Migliori ◽  
S. DE Pietro ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Microscopic Polyangiitis ◽  
Systemic Vasculitis ◽  
Renal Diseases ◽  
Dialysis Membrane ◽  
Dialysis Patients ◽  
Wegener Granulomatosis ◽  
Pathological Conditions ◽  
Strauss Syndrome ◽  
Churg Strauss

Background Anti-neutrophil cytoplasmic autoantibodies (ANCA) have been described in patients suffering from systemic vasculitis such as Wegener granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and other pathological conditions. In this paper we report a greater incidence of ANCA in hemodialysis patients as compared to peritoneal dialysis patients, predialytic uremic patients and non-renal patients; a possible role for dialysis bioincompatibility in ANCA generation was also investigated. Methods A total of 335 uremics in substitutive treatment (176 in hemodialytic treatment and 159 in peritoneal dialysis) were examined for ANCA positivity. A total of 189 patients with advanced renal failure in conservative treatment and 100 healthy subjects were used as control. The dialysis techniques were standard hemodialysis (n = 119), low volume hemodiafiltration (n = 26) and hemofiltration (n = 31). ANCA positivity was examined by immunofluorescence (IF): diffuse finely granular staining was considered as classical positive reaction (C-ANCA) and P-ANCA was diagnosed if a perinuclear staining was observed. EIA for proteinase-3 (anti PR-3) and myeloperoxidase-antibodies (anti-MPO) were also performed. Results In non-renal patients and in patients with pre-dialytic renal insufficiency none were found ANCA positive. In peritoneal dialysis patients all but one were ANCA negative with IF, with all EIA test resulting negative. In hemodialytic patients, a positive IF test was found in 26 (14.7%) for P-ANCA and in 5 (2.8%) for C-ANCA; using the EIA test 23 (13%) patients were positive for MPO and 12 (6.8%) for PR-3. Conclusions No correlation with age, primary renal diseases, dialytic age, dialysis membrane materials was found; regarding the different extracorporeal dialytic techniques a higher incidence (p < 0.02) was detected in patients undergoing HDF. Backfiltration of contaminated dialysate may induce ANCA via an increased cytokine generation. (Int J Artif Organs 2000; 23: 97–103)

Rheumatology

2016 ◽  
Keyword(s):  
Lupus Erythematosus ◽  
Basic Science ◽  
Granulomatosis With Polyangiitis ◽  
Systemic Vasculitis ◽  
Relapsing Polychondritis ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Basic Training ◽  
Strauss Syndrome ◽  
Eosinophilic Granulomatosis ◽  
Churg Strauss

Chapter 19 covers the basic science and clinical topics relating to rheumatology which trainees are required to learn as part of their basic training and demonstrate in the MRCP. It covers basic science, the synovium, autoantibodies, osteoarthritis, rheumatoid arthritis, septic arthritis, crystal arthropathies, spondyloarthritides, psoriatic arthritis, low back pain, systemic lupus erythematosus, systemic sclerosis, polymyositis/dermatomyositis, Sjögren syndrome, giant cell arteritis/polymyalgia rheumatic, polyarteritis nodosa, Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis), granulomatosis with polyangiitis (Wegener), treating systemic vasculitis, relapsing polychondritis, and Behҫet disease.

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