scholarly journals Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen Species

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Alberto López-Delis ◽  
Suélia de S. Rodrigues Fleury Rosa ◽  
Paulo Eduardo Narcizo de Souza ◽  
Marcella Lemos Brettas Carneiro ◽  
Mário Fabrício Fleury Rosa ◽  
...  
Keyword(s):  
Free Radical ◽  
Light Emitting Diode ◽  
Controlled Trial ◽  
Radical Formation ◽  
Lower Limbs ◽  
Paramagnetic Resonance ◽  
Healing Wound ◽  
Free Radical Formation ◽  
Group 2 ◽  
Circuit Group

The present study aims at evaluating the correlation between the free radical formation and the healing action of lower limbs’ ulcers in a randomized controlled trial with the use of an adhesive derived from natural latex associated with a light-emitting diode (LED) circuit. The sample consists of 15 participants with lower limb lesions divided into three groups: group 1 case (5 participants) received the proposed dressing system adhesive of the natural latex associated with the LED circuit; group 2 control (5 participants) received the dressings at home performed by nurses according to and established by the clinic of wounds (treated with calcium alginate or silver foam); and group 3 (5 participants) also received the dressing in their homes with the use of the dressing adhesive derived from the natural latex associated with the LED circuit. The collected data were analyzed qualitatively and quantitatively by electron paramagnetic resonance for determination of free radical formation. Kruskal-Wallis statistical test was used to evaluate the effect of treatment on the lower limb’s ulcer cicatrization process and its correlation with free radical. The results obtained corroborated the hypothesis about the reduction of the quantity of these molecules in the end of treatment related to the healing wound.

scholarly journals Influence of Temperature on Free Radical Generation in Propolis-Containing Ointments

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Paweł Olczyk ◽  
Pawel Ramos ◽  
Katarzyna Komosinska-Vassev ◽  
Lukasz Mencner ◽  
Krystyna Olczyk ◽  
...  
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Heating Temperature ◽  
Radical Formation ◽  
Paramagnetic Resonance ◽  
Influence Of Temperature ◽  
Spin Lattice ◽  
Influence Of Temperature On ◽  
Free Radical Formation ◽  
C 50

Free radicals thermally generated in the ointments containing propolis were studied by electron paramagnetic resonance (EPR) spectroscopy. The influence of temperature on the free radical concentration in the propolis ointments was examined. Two ointment samples with different contents of propolis (5 and 7%, resp.) heated at temperatures of 30°C, 40°C, 50°C, and 60°C, for 30 min., were tested. Homogeneously broadened EPR lines and fast spin-lattice interactions characterized all the tested samples. Free radicals concentrations in the propolis samples ranged from 1018 to 1020 spin/g and were found to grow in both propolis-containing ointments along with the increasing heating temperature. Free radical concentrations in the ointments containing 5% and 7% of propolis, respectively, heated at temperatures of 30°C, 40°C, and 50°C were only slightly different. Thermal treatment at the temperature of 60°C resulted in a considerably higher free radical formation in the sample containing 7% of propolis when related to the sample with 5% of that compound. The EPR examination indicated that the propolis ointments should not be stored at temperatures of 40°C, 50°C, and 60°C. Low free radical formation at the lowest tested temperatures pointed out that both examined propolis ointments may be safely stored up to the temperature of 30°C.

scholarly journals Wound-induced Free-radical Formation in Corn Seedlings

HortScience ◽  
1995 ◽  
Vol 30 (4) ◽  
pp. 897C-897
Author(s):  
Mitiku Girma ◽  
Alex I. Smirnov
Keyword(s):  
Free Radical ◽  
Epr Spectroscopy ◽  
Radical Formation ◽  
Single Line ◽  
Epr Spectrum ◽  
Paramagnetic Resonance ◽  
Root Injury ◽  
Free Radical Formation ◽  
G Value ◽  
Radical Signal

Recent studies performed at the Univ. of Sheffield (Sheffield, England) have established a correlation between the onset of senescence and the loss of viability in plants with a development of stable free-radicals that can be observed by Electron Paramagnetic Resonance (EPR) spectroscopy. We explored the possibility of free-radical formation following root injury of corn seedlings (Zea mays L.). Free radical signals were detected by EPR spectroscopy at 9.5 GHz. In all cases, we observed a single-line free-radical signal (g value ≈2.004) superimposed with six-line EPR spectrum from Mn2 + ions naturally present in the plant tissues. We determined a consistent increase in the intensity of single-line EPR signal after inducing root injury. This signal presumably is attributed to a quinone-derived radical and, as speculated, is associated with stressed respiratory transport chains. Based on our results, we suggest that free-radical reactions can be induced by root injury. Furthermore, an appearance of free-radical signal in the root may serve as an indication of a stress, natural and induced. If the precursors of observed free-radical signal can be determined, this will provide better insight on free-radical processes in plants followed by an injury. This work used the resources of the Illinois EPR Research Center (NIH P4 1 -RR0 1811).

In vivo thiyl free radical formation from hemoglobin following administration of hydroperoxides

1990 ◽  
Vol 277 (2) ◽  
pp. 402-409 ◽  
Author(s):  
Kirk R. Maples ◽  
Christopher H. Kennedy ◽  
Sandra J. Jordan ◽  
Ronald P. Mason
Keyword(s):  
Free Radical ◽  
Radical Formation ◽  
Free Radical Formation

scholarly journals Hydralazine-dependent carbon dioxide free radical formation by metabolizing mitochondria.

1988 ◽  
Vol 263 (23) ◽  
pp. 11296-11301 ◽  
Author(s):  
P K Wong ◽  
J L Poyer ◽  
C M DuBose ◽  
R A Floyd
Keyword(s):  
Carbon Dioxide ◽  
Free Radical ◽  
Radical Formation ◽  
Free Radical Formation
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