scholarly journals Influence of Disc Size on the Diagnostic Accuracy of Cirrus Spectral-Domain Optical Coherence Tomography in Glaucoma

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Shino Sato ◽  
Kaori Ukegawa ◽  
Eri Nitta ◽  
Kazuyuki Hirooka

Purpose. To examine the influence of optic disc size on the diagnostic accuracy of optic nerve head (ONH) parameters determined by Cirrus spectral-domain optical coherence tomography (Cirrus HD-OCT). Methods. A total of 51 eyes of 51 normal participants and 71 eyes of 71 glaucoma patients were examined. ONH imaging was obtained by Cirrus HD-OCT. Sensitivity at a fixed 90% specificity along with the area under the receiver operating characteristic curve (AUC) for continuous parameters were analyzed. We also examined the coefficients of variation (CoV) for sensitivity estimates, as these have been used to test and quantify the influence of optic disc size on diagnostic accuracy. The influence of optic disc size on the glaucoma diagnosis was assessed by the likelihood ratio chi-square test. Results. Among the continuous parameters, the best diagnostic accuracy was seen for the average rim area, which had an AUC of 0.96. The most reliable factor across the disc size groups was the rim area (CoV, 2.8%). The diagnostic accuracy of the rim area did not appear to be influenced by optic disc size (P=0.17). Conclusions. The high diagnostic accuracy of the rim area demonstrated by Cirrus HD-OCT for the quantitative assessment of the ONH was not significantly affected by disc size in this study.

2011 ◽  
Vol 52 (3) ◽  
pp. 1290 ◽  
Author(s):  
Harsha L. Rao ◽  
Mauro T. Leite ◽  
Robert N. Weinreb ◽  
Linda M. Zangwill ◽  
Luciana M. Alencar ◽  
...  

2006 ◽  
Vol 26 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Aljoscha S. Neubauer ◽  
Tina R. Krieglstein ◽  
Christos Chryssafis ◽  
Martin Thiel ◽  
Anselm Kampik

2011 ◽  
Vol 20 (6) ◽  
pp. 355-360 ◽  
Author(s):  
Pai-Huei Peng ◽  
Sheena Fu ◽  
Ngoc Nguyen ◽  
Travis Porco ◽  
Shan C. Lin

Ophthalmology ◽  
2010 ◽  
Vol 117 (9) ◽  
pp. 1692-1699.e1 ◽  
Author(s):  
Harsha L. Rao ◽  
Linda M. Zangwill ◽  
Robert N. Weinreb ◽  
Pamela A. Sample ◽  
Luciana M. Alencar ◽  
...  

2012 ◽  
Vol 57 (1) ◽  
pp. 108-112 ◽  
Author(s):  
Akiko Okubo ◽  
Kazuhiko Unoki ◽  
Hiroshi Yoshikawa ◽  
Tatsuro Ishibashi ◽  
Munefumi Sameshima ◽  
...  

Ophthalmology ◽  
2012 ◽  
Vol 119 (9) ◽  
pp. 1852-1857 ◽  
Author(s):  
Bingzhi Yang ◽  
Cong Ye ◽  
Marco Yu ◽  
Shu Liu ◽  
Dennis Shun Chiu Lam ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yasushi Shimada ◽  
Michael F. Burrow ◽  
Kazuyuki Araki ◽  
Yuan Zhou ◽  
Keiichi Hosaka ◽  
...  

Abstract Optical coherence tomography (OCT) can create cross-sectional images of tooth without X-ray exposure. This study aimed to investigate the diagnostic accuracy of 3D imaging of OCT for proximal caries in posterior teeth. Thirty-six human molar teeth with 51 proximal surfaces visibly 6 intact, 16 slightly demineralized, and 29 distinct carious changes were mounted to take digital radiographs and 3D OCT images. The sensitivity, specificity and area under the receiver operating characteristic curve (AUC) for the diagnosis of enamel caries and dentin caries were calculated to quantify the diagnostic ability of 3D OCT in comparison with digital radiography. Diagnostic accuracy was evaluated by the agreement with histology using weighted Kappa. OCT showed significantly higher sensitivity, AUC and Kappa values than radiography. OCT can be a safer option for the diagnosis of proximal caries in posterior teeth that can be applied to the patients without X-ray exposure.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
A. R. Kee ◽  
V. C. H. Yip ◽  
E. L. T. Tay ◽  
C. W. Lim ◽  
J. Cheng ◽  
...  

Abstract Background To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accuracy and test-retest reliability. Methods A cross-sectional observational study was performed on healthy and glaucoma subjects, on whom two sets of OCTA images of optic disc and macula were acquired using both AngioVue (Optovue, USA) and Swept Source (Topcon, Japan) OCTA devices during one visit. A novel in-house software was used to calculate the vessel densities. Diagnostic accuracy of the machines in differentiating healthy versus glaucomatous eyes was determined using area under the receiver operating characteristic curve (AUROC) and test-retest repeatability of the machines was also evaluated. Results A total of 80 healthy and 38 glaucomatous eyes were evaluated. Glaucomatous eyes had reduced mean vessel density compared to healthy controls in all segmented layers of the optic disc and macula using AngioVue (p ≤ 0.001). However, glaucomatous eyes had higher mean vessel density on optic disc scans using Swept Source, with lack of statistically significant difference between healthy and glaucomatous eyes. The AUROC showed better diagnostic accuracy of AngioVue (0.761–1.000) compared to Swept Source (0.113–0.644). The test-retest reliability indices were generally better using AngioVue than Swept Source. Conclusions AngioVue showed better diagnostic capability and test-retest reliability compared to Swept Source. Further studies need to be undertaken to evaluate if there is any significant difference between the various machines in diagnosing and monitoring glaucoma.


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