scholarly journals Case Report of Atypical Juxtaglomerular Cell Tumor

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Satoru Munakata ◽  
Eisuke Tomiyama ◽  
Hitoshi Takayama
Keyword(s):  
Tumor Cells ◽  
Gene Mutations ◽  
Massive Hemorrhage ◽  
Cell Tumor ◽  
Lower Portion ◽  
Juxtaglomerular Cell ◽  
Eosinophilic Cytoplasm ◽  
Potentially Malignant ◽  
Juxtaglomerular Cell Tumor ◽  
The Right

Juxtaglomerular cell tumor (JGCT) is a rare renal tumor, producing renin and behaving almost in a benign fashion. So far, only three cases have been reported as malignant. We report a rare case with atypical JGCT. A 74-year-old male was referred to our hospital due to hypertension, proteinuria, and hematuria. Abdominal CT revealed a mass measured in 9.7×7.0 cm in the lower portion of the right kidney. Right kidney was removed laparoscopically. Grossly, white to tan tumor with massive hemorrhage and necrosis occupied the lower portion of the right kidney. Microscopically, tumor grew in a solid fashion. Tumor cells were polygonal to ovoid cells with round nuclei and clear to eosinophilic cytoplasm. Mitosis was found in 5 per 10 HPF. Immunohistochemically, tumor cells were stained by vimentin and CD34. Some tumor cells were also positive for renin. Electron micrograph showed near rhomboid crystalline structure in the tumor cells. Because of massive necrosis and mitotic figures, diagnosis of atypical (potentially malignant) JGCT was rendered. Gene mutations for IDH1, PIK3CA, K-ras, N-ras, Braf, and EGFR were not found by MBP-QP system.

Laparoscopic resection of a juxtaglomerular cell tumor of the right kidney

2001 ◽  
Vol 16 (3) ◽  
pp. 539-539 ◽  
Author(s):  
F. Feliciotti ◽  
R. Campagnacci ◽  
S. Perretta ◽  
A.M. Paganini ◽  
M. Guerrieri ◽  
...  
Keyword(s):  
Laparoscopic Resection ◽  
Cell Tumor ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor ◽  
The Right

Juxtaglomerular Cell Tumor of Kidney With CD34 and CD117 Immunoreactivity: Report of 5 Cases

2006 ◽  
Vol 130 (5) ◽  
pp. 707-711 ◽  
Author(s):  
Hyun-Jung Kim ◽  
Chul Hwan Kim ◽  
Yeong-Jin Choi ◽  
Alberto G. Ayala ◽  
Mojgan Amirikachi ◽  
...  
Keyword(s):  
Microscopic Examination ◽  
Smooth Muscle Actin ◽  
Cell Tumor ◽  
Renal Tumors ◽  
Renal Neoplasm ◽  
Electron Microscopic ◽  
Primary Methods ◽  
Juxtaglomerular Cell ◽  
Eosinophilic Cytoplasm ◽  
Juxtaglomerular Cell Tumor

Abstract Context.—Juxtaglomerular cell tumor is a rare renal neoplasm. Renin immunohistochemistry and electron microscopic documentation of rhomboid crystals are the primary methods of diagnosing this benign tumor. Objectives.—In this retrospective study, we evaluated the morphologic, immunohistochemical, and ultrastructural features of 5 cases of juxtaglomerular cell tumor to determine the effectiveness of CD34 and CD117 immunohistochemistry for the diagnosis of this tumor. Design.—We reviewed 5 cases with clinical, histologic, immunohistochemical, and ultrastructural aspects. Results.—Three women and 2 men with a mean age of 37.8 years (range, 16–60 years) were included in this study. All patients presented with severe hypertension. All tumors were well circumscribed and ranged from 1.5 cm to 8.5 cm (mean, 4.4 cm). On light microscopic examination, we found solid sheets and nests of tumor cells with oval-to-round nuclei and eosinophilic cytoplasm. Low-power microscopic examination disclosed a hemangiopericytic vascular pattern. Immunohistochemistry results were as follows: vimentin (positive), renin (weakly positive), smooth muscle actin (focal immunoreactivity), and cytokeratin (negative). All 5 tumors were immunoreactive for CD34 and CD117. Electron microscopy revealed rhomboid crystals in the cytoplasm. Postoperatively, 4 patients were normotensive and 1 patient experienced persistent mild hypertension. Conclusions.—Our findings indicate that immunohistochemistry for CD34 and CD117 are effective at diagnosing juxtaglomerular cell tumor. Juxtaglomerular cell tumor should be considered in the diagnosis of any renal tumors with epithelioid cells and negative initial cytokeratin immunohistochemistry.

scholarly journals Juxtaglomerular cell tumor diagnosed preoperatively by renal tumor biopsy

2021 ◽  
Author(s):  
Takashi Ueda ◽  
Yukiko Morinaga ◽  
Kai Inoue ◽  
Sojiro Hirano ◽  
Hiroki Matsubara ◽  
...  
Keyword(s):  
Renal Tumor ◽  
Cell Tumor ◽  
Tumor Biopsy ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

Metastatic Juxtaglomerular Cell Tumor in a 52-Year-Old Man

2004 ◽  
Vol 28 (8) ◽  
pp. 1098-1102 ◽  
Author(s):  
Xiuzhen Duan ◽  
Patrick Bruneval ◽  
Rasheed Hammadeh ◽  
Raoul Fresco ◽  
John N Eble ◽  
...  
Keyword(s):  
Cell Tumor ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

Juxtaglomerular Cell Tumor of the Kidney

2020 ◽  
pp. 164-165
Author(s):  
Anna Caliò ◽  
Diego Segala ◽  
Guido Martignoni
Keyword(s):  
Cell Tumor ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

scholarly journals A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review

2018 ◽  
Vol 12 ◽  
pp. 117955491881353
Author(s):  
Yanling Zhang ◽  
Heng Tang ◽  
Huaiyuan Hu ◽  
Xiang Yong
Keyword(s):  
Thyroid Gland ◽  
Tumor Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Frozen Sections ◽  
Ki 67 ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
Painless Mass ◽  
The Right

Primary leiomyomas of the thyroid are very rare. We here report a case of a 53-year-old woman with a painless mass at the right thyroid, revealed by physical examination. The patient underwent a lobectomy. Frozen sections showed a spindle cell tumor of the thyroid gland. The nuclei of some of the tumor cells were obviously enlarged and deeply stained. Pseudocapsule invasion was observed in small foci. Samples showed neither mitosis nor necrosis and the nature of the tumor was difficult to determine. Paraffin sections showed a well-circumscribed nodular composed of intersecting fascicles of spindled to slightly epithelioid cells with eosinophilic cytoplasm and blunt-ended, cigar-shaped nuclei. We observed no significant nuclear atypia, mitotsis, or necrosis. Immunohistochemical staining showed the tumor cells to be positive for α-smooth muscle actin and h-caldesmon but negative for TG, TTF1, PAX8, S-100, CT, CK, and CD34. The ki-67 index was very low (<1%). Primary thyroid leiomyoma is rare and difficult to diagnose using frozen sections. Diagnosis requires immunohistochemical staining. Leiomyoma may be mistaken for other thyroid tumors also characterized by spindle cells.

scholarly journals Juxtaglomerular cell tumor: Clinical and immunohistochemical features

2017 ◽  
Vol 19 (8) ◽  
pp. 807-812 ◽  
Author(s):  
Fen Wang ◽  
Chuan Shi ◽  
Yunying Cui ◽  
Chunyan Li ◽  
Anli Tong
Keyword(s):  
Cell Tumor ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor
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